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An open trial and discontinuation study of fluoxetine in children and adolescents with obsessive-compulsive disorder.
Turk J Pediatr. 2001 Oct-Dec; 43(4):323-8.TJ

Abstract

The purpose of this study was to examine the efficacy and safety of fluoxetine for short-term and long-term treatment in children and adolescents with obsessive-compulsive disorder (OCD). Twenty-three children and adolescents (mean age 12.0, SD = 2.3) treated with fluoxetine for OCD with or without Gilles de la Tourette's syndrome were the subjects of this study. The design was an open-label trial for 20 weeks of fixed-dose fluoxetine (20 mg/day). OCD symptom severity was measured with the Maudsley OCD scale and with Clinical Global Impression Scale (CGI). All of the patients were followed-up after discontinuation of the drug for 24 months. Patients with OCD showed a significant decrease in the severity of their OCD symptoms according to Maudsley OCD scores (p < 0.001) and CGI scores (p < 0.001). Fluoxetine was generally well tolerated, and side effects were relatively mild. Ten patients (43.5%) with OCD who responded to fluoxetine relapsed in the follow-up period, but responded well to fluoxetine. These results indicate that fluoxetine is effective and safe for short-term and long-term treatment of OCD in children and adolescents.

Authors+Show Affiliations

Department of Child and Adolescent Psychiatry, Hacettepe University Faculty of Medicine, Ankara, Turkey.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

11765163

Citation

Semerci, Z B., and F Unal. "An Open Trial and Discontinuation Study of Fluoxetine in Children and Adolescents With Obsessive-compulsive Disorder." The Turkish Journal of Pediatrics, vol. 43, no. 4, 2001, pp. 323-8.
Semerci ZB, Unal F. An open trial and discontinuation study of fluoxetine in children and adolescents with obsessive-compulsive disorder. Turk J Pediatr. 2001;43(4):323-8.
Semerci, Z. B., & Unal, F. (2001). An open trial and discontinuation study of fluoxetine in children and adolescents with obsessive-compulsive disorder. The Turkish Journal of Pediatrics, 43(4), 323-8.
Semerci ZB, Unal F. An Open Trial and Discontinuation Study of Fluoxetine in Children and Adolescents With Obsessive-compulsive Disorder. Turk J Pediatr. 2001 Oct-Dec;43(4):323-8. PubMed PMID: 11765163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An open trial and discontinuation study of fluoxetine in children and adolescents with obsessive-compulsive disorder. AU - Semerci,Z B, AU - Unal,F, PY - 2002/1/5/pubmed PY - 2002/1/12/medline PY - 2002/1/5/entrez SP - 323 EP - 8 JF - The Turkish journal of pediatrics JO - Turk J Pediatr VL - 43 IS - 4 N2 - The purpose of this study was to examine the efficacy and safety of fluoxetine for short-term and long-term treatment in children and adolescents with obsessive-compulsive disorder (OCD). Twenty-three children and adolescents (mean age 12.0, SD = 2.3) treated with fluoxetine for OCD with or without Gilles de la Tourette's syndrome were the subjects of this study. The design was an open-label trial for 20 weeks of fixed-dose fluoxetine (20 mg/day). OCD symptom severity was measured with the Maudsley OCD scale and with Clinical Global Impression Scale (CGI). All of the patients were followed-up after discontinuation of the drug for 24 months. Patients with OCD showed a significant decrease in the severity of their OCD symptoms according to Maudsley OCD scores (p < 0.001) and CGI scores (p < 0.001). Fluoxetine was generally well tolerated, and side effects were relatively mild. Ten patients (43.5%) with OCD who responded to fluoxetine relapsed in the follow-up period, but responded well to fluoxetine. These results indicate that fluoxetine is effective and safe for short-term and long-term treatment of OCD in children and adolescents. SN - 0041-4301 UR - https://www.unboundmedicine.com/medline/citation/11765163/An_open_trial_and_discontinuation_study_of_fluoxetine_in_children_and_adolescents_with_obsessive_compulsive_disorder_ L2 - https://www.diseaseinfosearch.org/result/5285 DB - PRIME DP - Unbound Medicine ER -