TY - JOUR T1 - An open trial and discontinuation study of fluoxetine in children and adolescents with obsessive-compulsive disorder. AU - Semerci,Z B, AU - Unal,F, PY - 2002/1/5/pubmed PY - 2002/1/12/medline PY - 2002/1/5/entrez SP - 323 EP - 8 JF - The Turkish journal of pediatrics JO - Turk J Pediatr VL - 43 IS - 4 N2 - The purpose of this study was to examine the efficacy and safety of fluoxetine for short-term and long-term treatment in children and adolescents with obsessive-compulsive disorder (OCD). Twenty-three children and adolescents (mean age 12.0, SD = 2.3) treated with fluoxetine for OCD with or without Gilles de la Tourette's syndrome were the subjects of this study. The design was an open-label trial for 20 weeks of fixed-dose fluoxetine (20 mg/day). OCD symptom severity was measured with the Maudsley OCD scale and with Clinical Global Impression Scale (CGI). All of the patients were followed-up after discontinuation of the drug for 24 months. Patients with OCD showed a significant decrease in the severity of their OCD symptoms according to Maudsley OCD scores (p < 0.001) and CGI scores (p < 0.001). Fluoxetine was generally well tolerated, and side effects were relatively mild. Ten patients (43.5%) with OCD who responded to fluoxetine relapsed in the follow-up period, but responded well to fluoxetine. These results indicate that fluoxetine is effective and safe for short-term and long-term treatment of OCD in children and adolescents. SN - 0041-4301 UR - https://www.unboundmedicine.com/medline/citation/11765163/An_open_trial_and_discontinuation_study_of_fluoxetine_in_children_and_adolescents_with_obsessive_compulsive_disorder_ L2 - https://www.diseaseinfosearch.org/result/5285 DB - PRIME DP - Unbound Medicine ER -