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Cardiovascular risk factors as determinants of 25-year all-cause mortality in the seven countries study.
Eur J Epidemiol. 2001; 17(4):337-46.EJ

Abstract

This analysis aims at describing all-cause mortality and their determinants in 16 cohorts of middle-aged men of eight nations. A total of 12,763 men aged 40-59 years were enrolled in the late 1950s and early 1960s in 16 cohorts located in the USA, Finland, The Netherlands, Italy, Croatia, Serbia, Greece and Japan. The highest death rates were found in Slavonia-Croatia, due to high rates of infectious diseases and violence (death rate of 610 per 1000), and in East Finland due to high rates from coronary heart disease (death rate of 597 per 1000). The lowest death rates were found in a highly educated group in Belgrade, Serbia (death rate 295 per 1000) and in Crete, Greece (death rate 314 per 1000). The ecological analysis showed no significant relationship between mean risk factor levels and all-cause death rates except for the direct association with systolic blood pressure during the first 15 years follow-up. Individual multivariate analysis on eight national pools showed that age, systolic blood pressure, and smoking habits are direct, significant, and universal long-term predictors of all-cause mortality. Serum cholesterol, physical activity and body mass index were so only in some areas. Multivariate coefficients were similar across nations. Pooled hazards ratios were 1.55 for a difference of 5 years of age (CI: 1.51-1.59); 1.23 for 10 cigarettes smoked per day (CI: 1.20-1.26); 0.91 for one unit (based on three grades) of physical activity score (CI: 0.87-0.95); 1.04 for 1 mmol/l of serum cholesterol (CI: 1.02-1.07); and 0.93 for three units of body mass index (CI: 0.91-0.96). In conclusion some cardiovascular risk factors predict long-term risk of all-cause mortality in different cultures.

Authors+Show Affiliations

Division of Epidemiology, University of Minnesota, Minneapolis, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11767959

Citation

Menotti, A, et al. "Cardiovascular Risk Factors as Determinants of 25-year All-cause Mortality in the Seven Countries Study." European Journal of Epidemiology, vol. 17, no. 4, 2001, pp. 337-46.
Menotti A, Blackburn H, Kromhout D, et al. Cardiovascular risk factors as determinants of 25-year all-cause mortality in the seven countries study. Eur J Epidemiol. 2001;17(4):337-46.
Menotti, A., Blackburn, H., Kromhout, D., Nissinen, A., Adachi, H., & Lanti, M. (2001). Cardiovascular risk factors as determinants of 25-year all-cause mortality in the seven countries study. European Journal of Epidemiology, 17(4), 337-46.
Menotti A, et al. Cardiovascular Risk Factors as Determinants of 25-year All-cause Mortality in the Seven Countries Study. Eur J Epidemiol. 2001;17(4):337-46. PubMed PMID: 11767959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risk factors as determinants of 25-year all-cause mortality in the seven countries study. AU - Menotti,A, AU - Blackburn,H, AU - Kromhout,D, AU - Nissinen,A, AU - Adachi,H, AU - Lanti,M, PY - 2002/1/5/pubmed PY - 2002/5/25/medline PY - 2002/1/5/entrez SP - 337 EP - 46 JF - European journal of epidemiology JO - Eur. J. Epidemiol. VL - 17 IS - 4 N2 - This analysis aims at describing all-cause mortality and their determinants in 16 cohorts of middle-aged men of eight nations. A total of 12,763 men aged 40-59 years were enrolled in the late 1950s and early 1960s in 16 cohorts located in the USA, Finland, The Netherlands, Italy, Croatia, Serbia, Greece and Japan. The highest death rates were found in Slavonia-Croatia, due to high rates of infectious diseases and violence (death rate of 610 per 1000), and in East Finland due to high rates from coronary heart disease (death rate of 597 per 1000). The lowest death rates were found in a highly educated group in Belgrade, Serbia (death rate 295 per 1000) and in Crete, Greece (death rate 314 per 1000). The ecological analysis showed no significant relationship between mean risk factor levels and all-cause death rates except for the direct association with systolic blood pressure during the first 15 years follow-up. Individual multivariate analysis on eight national pools showed that age, systolic blood pressure, and smoking habits are direct, significant, and universal long-term predictors of all-cause mortality. Serum cholesterol, physical activity and body mass index were so only in some areas. Multivariate coefficients were similar across nations. Pooled hazards ratios were 1.55 for a difference of 5 years of age (CI: 1.51-1.59); 1.23 for 10 cigarettes smoked per day (CI: 1.20-1.26); 0.91 for one unit (based on three grades) of physical activity score (CI: 0.87-0.95); 1.04 for 1 mmol/l of serum cholesterol (CI: 1.02-1.07); and 0.93 for three units of body mass index (CI: 0.91-0.96). In conclusion some cardiovascular risk factors predict long-term risk of all-cause mortality in different cultures. SN - 0393-2990 UR - https://www.unboundmedicine.com/medline/citation/11767959/Cardiovascular_risk_factors_as_determinants_of_25_year_all_cause_mortality_in_the_seven_countries_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11767959.ui DB - PRIME DP - Unbound Medicine ER -