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[Changes of serum transferrin receptor in children with iron deficiency and its response to iron supplementation].
Zhonghua Yu Fang Yi Xue Za Zhi. 2001 Sep; 35(5):325-8.ZY

Abstract

OBJECTIVES

To study the level of serum transferrin receptor (sTfR) in children with different stages of iron deficiency, as well as in the normal children, to observe its response to iron supplementation, and to explore the role of sTfR in surveillance of iron status and assessment of iron supplementation in population.

METHODS

By determining iron status index, 1,006 children aged 6-14 years in Fangshan District, Beijing were divided into four groups, control group, iron depletion (ID) group, iron deficiency erythropoiesis (IDE) group and iron deficiency anemia (IDA) group, and 239 of them were measured for sTfR with Quintikine enzyme immunoassay (R&D system, Minneapolis, MN) and sTfR/logserum ferratin (SF) was estimated. Iron supplementation (NaFeEDTA capsules, containing 60 mg iron element per capsule) was administered for the children with ID and IDE per capsule once weekly and for the children with IDA per capsule thrice weekly for nine weeks. Iron status index and sTfR were measured before and after iron supplementation.

RESULTS

The levels of sTfR and sTfR/log SF in children with ID, IDE and IDA were (20.03 +/- 2.33) nmol/L, (24.52 +/- 1.07) nmol/L, (33.28 +/- 6.09) nmol/L and (18.15 +/- 5.31), (20.98 +/- 8.88), (29.08 +/- 8.57), respectively, significantly higher than those in the control group [sTfR(18.74 +/- 3.06) nmol/L and sTfR/log SF(9.89 +/- 1.74)]. Statistical analysis showed that sTfR correlated to free erythrocyte protoporphyrin and hemoglobin. sTfR levels in normal children was (12.5-23.5) nmol/L. After iron supplementation, sTfR levels in children with ID was (16.37 +/- 3.10) nmol/L, significantly decreased than those before iron supplementation, but no change in sTfR was observed in children with IDE and IDA. sTfR/log SF were decreased significantly in all children with ID group(11.42 +/- 3.12), IDE (16.54 +/- 4.70) and IDA (23.59 +/- 9.93).

CONCLUSION

sTfR is a specific indicator for identifying IDE and IDA, and sTfR/log SF is a sensitive index for assessing the effects of iron supplementation.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11769633

Citation

Lin, X, et al. "[Changes of Serum Transferrin Receptor in Children With Iron Deficiency and Its Response to Iron Supplementation]." Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], vol. 35, no. 5, 2001, pp. 325-8.
Lin X, Long Z, Shen X. [Changes of serum transferrin receptor in children with iron deficiency and its response to iron supplementation]. Zhonghua Yu Fang Yi Xue Za Zhi. 2001;35(5):325-8.
Lin, X., Long, Z., & Shen, X. (2001). [Changes of serum transferrin receptor in children with iron deficiency and its response to iron supplementation]. Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], 35(5), 325-8.
Lin X, Long Z, Shen X. [Changes of Serum Transferrin Receptor in Children With Iron Deficiency and Its Response to Iron Supplementation]. Zhonghua Yu Fang Yi Xue Za Zhi. 2001;35(5):325-8. PubMed PMID: 11769633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Changes of serum transferrin receptor in children with iron deficiency and its response to iron supplementation]. AU - Lin,X, AU - Long,Z, AU - Shen,X, PY - 2002/1/5/pubmed PY - 2002/3/5/medline PY - 2002/1/5/entrez SP - 325 EP - 8 JF - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] JO - Zhonghua Yu Fang Yi Xue Za Zhi VL - 35 IS - 5 N2 - OBJECTIVES: To study the level of serum transferrin receptor (sTfR) in children with different stages of iron deficiency, as well as in the normal children, to observe its response to iron supplementation, and to explore the role of sTfR in surveillance of iron status and assessment of iron supplementation in population. METHODS: By determining iron status index, 1,006 children aged 6-14 years in Fangshan District, Beijing were divided into four groups, control group, iron depletion (ID) group, iron deficiency erythropoiesis (IDE) group and iron deficiency anemia (IDA) group, and 239 of them were measured for sTfR with Quintikine enzyme immunoassay (R&D system, Minneapolis, MN) and sTfR/logserum ferratin (SF) was estimated. Iron supplementation (NaFeEDTA capsules, containing 60 mg iron element per capsule) was administered for the children with ID and IDE per capsule once weekly and for the children with IDA per capsule thrice weekly for nine weeks. Iron status index and sTfR were measured before and after iron supplementation. RESULTS: The levels of sTfR and sTfR/log SF in children with ID, IDE and IDA were (20.03 +/- 2.33) nmol/L, (24.52 +/- 1.07) nmol/L, (33.28 +/- 6.09) nmol/L and (18.15 +/- 5.31), (20.98 +/- 8.88), (29.08 +/- 8.57), respectively, significantly higher than those in the control group [sTfR(18.74 +/- 3.06) nmol/L and sTfR/log SF(9.89 +/- 1.74)]. Statistical analysis showed that sTfR correlated to free erythrocyte protoporphyrin and hemoglobin. sTfR levels in normal children was (12.5-23.5) nmol/L. After iron supplementation, sTfR levels in children with ID was (16.37 +/- 3.10) nmol/L, significantly decreased than those before iron supplementation, but no change in sTfR was observed in children with IDE and IDA. sTfR/log SF were decreased significantly in all children with ID group(11.42 +/- 3.12), IDE (16.54 +/- 4.70) and IDA (23.59 +/- 9.93). CONCLUSION: sTfR is a specific indicator for identifying IDE and IDA, and sTfR/log SF is a sensitive index for assessing the effects of iron supplementation. SN - 0253-9624 UR - https://www.unboundmedicine.com/medline/citation/11769633/[Changes_of_serum_transferrin_receptor_in_children_with_iron_deficiency_and_its_response_to_iron_supplementation]_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -