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[Association between polymorphism of alpha 1-antichymotrypsin and apolipoprotein E gene and Parkinson's disease in Shanghai Hans].
Zhonghua Yi Xue Za Zhi. 2001 Oct; 81(19):1172-5.ZY

Abstract

OBJECTIVE

To explore the relationship between polymorphism of alpha 1-antichymotrypsin(AACT) and apolipoprotein E(ApoE) genes and the risk of Parkinson's disease(PD) in Shanghai Hans.

METHODS

Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to study the distribution of AACT and ApoE gene polymorphism in 64 PD cases and 101 healthy elderly persons as controls. Association analysis was performed using odds ratio (OR) and chi 2 test.

RESULTS

No difference in distribution of AACT A/T allele polymorphism was found between PD cases and healthy controls(chi 2 = 0.83 P = 0.363 > 0.05), but AACT-AA genotype was associated with PD(OR = 2.68, chi 2 = 4.31 P = 0.038 < 0.05). The ApoE gene polymorphism was not associated with PD(allele: chi 2 = 2.85 P = 0.241 > 0.05; genotype: chi 2 = 9.25 P = 0.099 > 0.05). The AACT-AT genotype frequency in PD patients was significantly lower than that in the controls without ApoE epsilon 4 allele(OR = 0.47, chi 2 = 4.10 P = 0.043 < 0.05). In AACT-AT genotype the ApoE epsilon 4 allele was associated with PD(OR = 3.26, chi 2 = 5.53 P = 0.019 < 0.05).

CONCLUSION

The AACT-AA genotype and AACT-AT genotype with ApoE epsilon 4 might be susceptible factors for PD in Shanghai Hans.

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Authors+Show Affiliations

Hao Y
Department of Neurology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Xie H
No affiliation info available
Xu L
No affiliation info available

MeSH

AdultAgedAllelesApolipoproteins EChinaDNAFemaleGene FrequencyGenotypeHumansMaleMiddle AgedParkinson DiseasePolymorphism, GeneticPolymorphism, Restriction Fragment Lengthalpha 1-Antichymotrypsin

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11769703

Citation

Hao, Y, et al. "[Association Between Polymorphism of Alpha 1-antichymotrypsin and Apolipoprotein E Gene and Parkinson's Disease in Shanghai Hans]." Zhonghua Yi Xue Za Zhi, vol. 81, no. 19, 2001, pp. 1172-5.
Hao Y, Xie H, Xu L. [Association between polymorphism of alpha 1-antichymotrypsin and apolipoprotein E gene and Parkinson's disease in Shanghai Hans]. Zhonghua Yi Xue Za Zhi. 2001;81(19):1172-5.
Hao, Y., Xie, H., & Xu, L. (2001). [Association between polymorphism of alpha 1-antichymotrypsin and apolipoprotein E gene and Parkinson's disease in Shanghai Hans]. Zhonghua Yi Xue Za Zhi, 81(19), 1172-5.
Hao Y, Xie H, Xu L. [Association Between Polymorphism of Alpha 1-antichymotrypsin and Apolipoprotein E Gene and Parkinson's Disease in Shanghai Hans]. Zhonghua Yi Xue Za Zhi. 2001;81(19):1172-5. PubMed PMID: 11769703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Association between polymorphism of alpha 1-antichymotrypsin and apolipoprotein E gene and Parkinson's disease in Shanghai Hans]. AU - Hao,Y, AU - Xie,H, AU - Xu,L, PY - 2002/1/5/pubmed PY - 2002/1/16/medline PY - 2002/1/5/entrez SP - 1172 EP - 5 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 81 IS - 19 N2 - OBJECTIVE: To explore the relationship between polymorphism of alpha 1-antichymotrypsin(AACT) and apolipoprotein E(ApoE) genes and the risk of Parkinson's disease(PD) in Shanghai Hans. METHODS: Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to study the distribution of AACT and ApoE gene polymorphism in 64 PD cases and 101 healthy elderly persons as controls. Association analysis was performed using odds ratio (OR) and chi 2 test. RESULTS: No difference in distribution of AACT A/T allele polymorphism was found between PD cases and healthy controls(chi 2 = 0.83 P = 0.363 > 0.05), but AACT-AA genotype was associated with PD(OR = 2.68, chi 2 = 4.31 P = 0.038 < 0.05). The ApoE gene polymorphism was not associated with PD(allele: chi 2 = 2.85 P = 0.241 > 0.05; genotype: chi 2 = 9.25 P = 0.099 > 0.05). The AACT-AT genotype frequency in PD patients was significantly lower than that in the controls without ApoE epsilon 4 allele(OR = 0.47, chi 2 = 4.10 P = 0.043 < 0.05). In AACT-AT genotype the ApoE epsilon 4 allele was associated with PD(OR = 3.26, chi 2 = 5.53 P = 0.019 < 0.05). CONCLUSION: The AACT-AA genotype and AACT-AT genotype with ApoE epsilon 4 might be susceptible factors for PD in Shanghai Hans. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/11769703/[Association_between_polymorphism_of_alpha_1_antichymotrypsin_and_apolipoprotein_E_gene_and_Parkinson's_disease_in_Shanghai_Hans]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2001&amp;vol=81&amp;issue=19&amp;fpage=1172 DB - PRIME DP - Unbound Medicine ER -