Tags

Type your tag names separated by a space and hit enter

[Characterisation of transient outward potassium current (Ito1) in hypertrophied right ventricular myocytes from children with tetralogy of Fallot].
Zhonghua Yi Xue Za Zhi. 2001 Oct; 81(19):1190-3.ZY

Abstract

OBJECTIVE

To investigate whether a transient outward potassium current exists in children hypertrophy ventricular myocytes and to characterize its basic electrophysiological properties.

METHODS

Currents were recorded using whole-cell patch-clamp technique from enzymatically isolated ventricualr myocytes obtained from hearts of 10 patients aged 0.4-5 with tetralogy of Fallot (F4) ranging in age 0.4-5 years.

RESULTS

In almost all cells studied, a Ito1 could be recorded on depolarization to between -20(-)+60 mV under conditions in which Ca2+ current was blocked. The current density is 4.7 PA/PF +/- 0.6 PA/PF at 60 mV. Its inactivation time constants under tested potential 0, 20, 40, 60 mV were 123 ms +/- 6 ms, 131 ms +/- 11 ms, 122 ms +/- 6 ms, 122 ms +/- 6 ms Half-maximal activation occurred at 4.1 mV +/- 2.8 mV. Half-maximal steady-state inactivation was -41 mV +/- 4 mV. Recovery from inactivation was voltage-dependent and the time course was 83 ms +/- 4 ms.

CONCLUSION

A moderate Ca(2+)-independent transient outward K+ current is present in hypertrophied human ventricular myocytes from children with tetralogy of Fallot, its basic characteritics are similar to Ito1 observed in other species and human atria.

Authors+Show Affiliations

Department of Anesthesiology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11769708

Citation

Sun, X, et al. "[Characterisation of Transient Outward Potassium Current (Ito1) in Hypertrophied Right Ventricular Myocytes From Children With Tetralogy of Fallot]." Zhonghua Yi Xue Za Zhi, vol. 81, no. 19, 2001, pp. 1190-3.
Sun X, Hu X, Zhang B. [Characterisation of transient outward potassium current (Ito1) in hypertrophied right ventricular myocytes from children with tetralogy of Fallot]. Zhonghua Yi Xue Za Zhi. 2001;81(19):1190-3.
Sun, X., Hu, X., & Zhang, B. (2001). [Characterisation of transient outward potassium current (Ito1) in hypertrophied right ventricular myocytes from children with tetralogy of Fallot]. Zhonghua Yi Xue Za Zhi, 81(19), 1190-3.
Sun X, Hu X, Zhang B. [Characterisation of Transient Outward Potassium Current (Ito1) in Hypertrophied Right Ventricular Myocytes From Children With Tetralogy of Fallot]. Zhonghua Yi Xue Za Zhi. 2001;81(19):1190-3. PubMed PMID: 11769708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Characterisation of transient outward potassium current (Ito1) in hypertrophied right ventricular myocytes from children with tetralogy of Fallot]. AU - Sun,X, AU - Hu,X, AU - Zhang,B, PY - 2002/1/5/pubmed PY - 2002/1/16/medline PY - 2002/1/5/entrez SP - 1190 EP - 3 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 81 IS - 19 N2 - OBJECTIVE: To investigate whether a transient outward potassium current exists in children hypertrophy ventricular myocytes and to characterize its basic electrophysiological properties. METHODS: Currents were recorded using whole-cell patch-clamp technique from enzymatically isolated ventricualr myocytes obtained from hearts of 10 patients aged 0.4-5 with tetralogy of Fallot (F4) ranging in age 0.4-5 years. RESULTS: In almost all cells studied, a Ito1 could be recorded on depolarization to between -20(-)+60 mV under conditions in which Ca2+ current was blocked. The current density is 4.7 PA/PF +/- 0.6 PA/PF at 60 mV. Its inactivation time constants under tested potential 0, 20, 40, 60 mV were 123 ms +/- 6 ms, 131 ms +/- 11 ms, 122 ms +/- 6 ms, 122 ms +/- 6 ms Half-maximal activation occurred at 4.1 mV +/- 2.8 mV. Half-maximal steady-state inactivation was -41 mV +/- 4 mV. Recovery from inactivation was voltage-dependent and the time course was 83 ms +/- 4 ms. CONCLUSION: A moderate Ca(2+)-independent transient outward K+ current is present in hypertrophied human ventricular myocytes from children with tetralogy of Fallot, its basic characteritics are similar to Ito1 observed in other species and human atria. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/11769708/[Characterisation_of_transient_outward_potassium_current__Ito1__in_hypertrophied_right_ventricular_myocytes_from_children_with_tetralogy_of_Fallot]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0376-2491&year=2001&vol=81&issue=19&fpage=1190 DB - PRIME DP - Unbound Medicine ER -