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[Characterisation of transient outward potassium current (Ito1) in hypertrophied right ventricular myocytes from children with tetralogy of Fallot].
Zhonghua Yi Xue Za Zhi. 2001 Oct; 81(19):1190-3.ZY

Abstract

OBJECTIVE

To investigate whether a transient outward potassium current exists in children hypertrophy ventricular myocytes and to characterize its basic electrophysiological properties.

METHODS

Currents were recorded using whole-cell patch-clamp technique from enzymatically isolated ventricualr myocytes obtained from hearts of 10 patients aged 0.4-5 with tetralogy of Fallot (F4) ranging in age 0.4-5 years.

RESULTS

In almost all cells studied, a Ito1 could be recorded on depolarization to between -20(-)+60 mV under conditions in which Ca2+ current was blocked. The current density is 4.7 PA/PF +/- 0.6 PA/PF at 60 mV. Its inactivation time constants under tested potential 0, 20, 40, 60 mV were 123 ms +/- 6 ms, 131 ms +/- 11 ms, 122 ms +/- 6 ms, 122 ms +/- 6 ms Half-maximal activation occurred at 4.1 mV +/- 2.8 mV. Half-maximal steady-state inactivation was -41 mV +/- 4 mV. Recovery from inactivation was voltage-dependent and the time course was 83 ms +/- 4 ms.

CONCLUSION

A moderate Ca(2+)-independent transient outward K+ current is present in hypertrophied human ventricular myocytes from children with tetralogy of Fallot, its basic characteritics are similar to Ito1 observed in other species and human atria.

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Authors+Show Affiliations

Sun X
Department of Anesthesiology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China.
Hu X
No affiliation info available
Zhang B
No affiliation info available

MeSH

Child, PreschoolElectric StimulationFemaleHumansHypertrophy, Right VentricularInfantMaleMembrane PotentialsPatch-Clamp TechniquesPotassium ChannelsTetralogy of FallotTime Factors

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11769708

Citation

Sun, X, et al. "[Characterisation of Transient Outward Potassium Current (Ito1) in Hypertrophied Right Ventricular Myocytes From Children With Tetralogy of Fallot]." Zhonghua Yi Xue Za Zhi, vol. 81, no. 19, 2001, pp. 1190-3.
Sun X, Hu X, Zhang B. [Characterisation of transient outward potassium current (Ito1) in hypertrophied right ventricular myocytes from children with tetralogy of Fallot]. Zhonghua Yi Xue Za Zhi. 2001;81(19):1190-3.
Sun, X., Hu, X., & Zhang, B. (2001). [Characterisation of transient outward potassium current (Ito1) in hypertrophied right ventricular myocytes from children with tetralogy of Fallot]. Zhonghua Yi Xue Za Zhi, 81(19), 1190-3.
Sun X, Hu X, Zhang B. [Characterisation of Transient Outward Potassium Current (Ito1) in Hypertrophied Right Ventricular Myocytes From Children With Tetralogy of Fallot]. Zhonghua Yi Xue Za Zhi. 2001;81(19):1190-3. PubMed PMID: 11769708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Characterisation of transient outward potassium current (Ito1) in hypertrophied right ventricular myocytes from children with tetralogy of Fallot]. AU - Sun,X, AU - Hu,X, AU - Zhang,B, PY - 2002/1/5/pubmed PY - 2002/1/16/medline PY - 2002/1/5/entrez SP - 1190 EP - 3 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 81 IS - 19 N2 - OBJECTIVE: To investigate whether a transient outward potassium current exists in children hypertrophy ventricular myocytes and to characterize its basic electrophysiological properties. METHODS: Currents were recorded using whole-cell patch-clamp technique from enzymatically isolated ventricualr myocytes obtained from hearts of 10 patients aged 0.4-5 with tetralogy of Fallot (F4) ranging in age 0.4-5 years. RESULTS: In almost all cells studied, a Ito1 could be recorded on depolarization to between -20(-)+60 mV under conditions in which Ca2+ current was blocked. The current density is 4.7 PA/PF +/- 0.6 PA/PF at 60 mV. Its inactivation time constants under tested potential 0, 20, 40, 60 mV were 123 ms +/- 6 ms, 131 ms +/- 11 ms, 122 ms +/- 6 ms, 122 ms +/- 6 ms Half-maximal activation occurred at 4.1 mV +/- 2.8 mV. Half-maximal steady-state inactivation was -41 mV +/- 4 mV. Recovery from inactivation was voltage-dependent and the time course was 83 ms +/- 4 ms. CONCLUSION: A moderate Ca(2+)-independent transient outward K+ current is present in hypertrophied human ventricular myocytes from children with tetralogy of Fallot, its basic characteritics are similar to Ito1 observed in other species and human atria. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/11769708/[Characterisation_of_transient_outward_potassium_current__Ito1__in_hypertrophied_right_ventricular_myocytes_from_children_with_tetralogy_of_Fallot]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0376-2491&year=2001&vol=81&issue=19&fpage=1190 DB - PRIME DP - Unbound Medicine ER -