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Differential contribution of frontal and temporal cortices to auditory change detection: fMRI and ERP results.
Neuroimage. 2002 Jan; 15(1):167-74.N

Abstract

The present study addresses the functional role of the temporal and frontal lobes in auditory change detection. Prior event-related potential (ERP) research suggested that the mismatch negativity (MMN) reflects the involvement of a temporofrontal network subserving auditory change detection processes and the initiation of an involuntary attention switch. In the present study participants were presented with repetitive spectrally rich sounds. Infrequent changes of either small (10% change), medium (30% change), or large (100% change) magnitude were embedded in the stimulus train. ERPs and fMRI measures were obtained in the same subjects in subsequent sessions. Significant hemodynamic activation in the superior temporal gyri (STG) bilaterally and the opercular part of the right inferior frontal gyrus was observed for large and medium deviants only. ERPs showed that small deviants elicited MMN when presented in silence but not when presented with recorded MR background noise, indicating that small deviants were hardly detected under fMRI conditions. The MR signal change in temporal lobe regions was larger for large than for medium deviants. For the right fronto-opercular cortex the opposite pattern was observed. The strength of the temporal activation correlated with the amplitude of the change-related ERP at around 110 ms from stimulus onset while the frontal activation correlated with the change-related ERP at around 150 ms. These results suggest that the right fronto-opercular cortex is part of the neural network generating the MMN. Three alternative explanations of these findings are discussed.

Authors+Show Affiliations

Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany. opitz@cns.mpg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11771985

Citation

Opitz, Bertram, et al. "Differential Contribution of Frontal and Temporal Cortices to Auditory Change Detection: fMRI and ERP Results." NeuroImage, vol. 15, no. 1, 2002, pp. 167-74.
Opitz B, Rinne T, Mecklinger A, et al. Differential contribution of frontal and temporal cortices to auditory change detection: fMRI and ERP results. Neuroimage. 2002;15(1):167-74.
Opitz, B., Rinne, T., Mecklinger, A., von Cramon, D. Y., & Schröger, E. (2002). Differential contribution of frontal and temporal cortices to auditory change detection: fMRI and ERP results. NeuroImage, 15(1), 167-74.
Opitz B, et al. Differential Contribution of Frontal and Temporal Cortices to Auditory Change Detection: fMRI and ERP Results. Neuroimage. 2002;15(1):167-74. PubMed PMID: 11771985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential contribution of frontal and temporal cortices to auditory change detection: fMRI and ERP results. AU - Opitz,Bertram, AU - Rinne,Teemu, AU - Mecklinger,Axel, AU - von Cramon,D Yves, AU - Schröger,Erich, PY - 2002/1/5/pubmed PY - 2002/3/21/medline PY - 2002/1/5/entrez SP - 167 EP - 74 JF - NeuroImage JO - Neuroimage VL - 15 IS - 1 N2 - The present study addresses the functional role of the temporal and frontal lobes in auditory change detection. Prior event-related potential (ERP) research suggested that the mismatch negativity (MMN) reflects the involvement of a temporofrontal network subserving auditory change detection processes and the initiation of an involuntary attention switch. In the present study participants were presented with repetitive spectrally rich sounds. Infrequent changes of either small (10% change), medium (30% change), or large (100% change) magnitude were embedded in the stimulus train. ERPs and fMRI measures were obtained in the same subjects in subsequent sessions. Significant hemodynamic activation in the superior temporal gyri (STG) bilaterally and the opercular part of the right inferior frontal gyrus was observed for large and medium deviants only. ERPs showed that small deviants elicited MMN when presented in silence but not when presented with recorded MR background noise, indicating that small deviants were hardly detected under fMRI conditions. The MR signal change in temporal lobe regions was larger for large than for medium deviants. For the right fronto-opercular cortex the opposite pattern was observed. The strength of the temporal activation correlated with the amplitude of the change-related ERP at around 110 ms from stimulus onset while the frontal activation correlated with the change-related ERP at around 150 ms. These results suggest that the right fronto-opercular cortex is part of the neural network generating the MMN. Three alternative explanations of these findings are discussed. SN - 1053-8119 UR - https://www.unboundmedicine.com/medline/citation/11771985/Differential_contribution_of_frontal_and_temporal_cortices_to_auditory_change_detection:_fMRI_and_ERP_results_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S105381190190970X DB - PRIME DP - Unbound Medicine ER -