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Soluble cell adhesion molecules in patients with acute coronary syndrome.
Chin Med J (Engl). 2000 Mar; 113(3):286-8.CM

Abstract

OBJECTIVE

To observe the changes in serum soluble intercellular adhesion molecule type-1 (ICAM-1), vascular cell adhesion molecule type-1 (VCAM-1), E-selectin and von Willebrand factor (vWf) in patients with acute coronary syndrome.

METHODS

Serial venous blood samples were taken from 21 patients with acute myocardial infarction (AMI) before and 4, 8, 12, 24, 48 and 72 h after thrombolytic treatment or direct PTCA. One blood sample was drawn from 16 patients with unstable angina and 16 control subjects. Serum concentrations of ICAM-1, VCAM-1, E-selectin and vWf were determined using a double antibody sandwich enzyme-linked immunosorbent assay.

RESULTS

Serum levels of ICAM-1, VCAM-1, E-selectin and vWf were higher in patients with acute coronary syndrome than in controls. Patients with AMI and successful reperfusion therapy had a significant reduction in the serum concentration of ICAM-1 and E-selectin at 24 and 48 h, VCAM-1 at 24 and 72 h and vWf at 12, 24, 48 and 72 h, but had peak in serum levels of ICAM-1 and E-selectin at 4 h. The number of diseased coronary arteries was not related to the levels of ICAM-1, VCAM-1 and E-selecin.

CONCLUSION

The serum concentration of soluble cell adhesion molecules was elevated significantly in patients with acute coronary syndrome. Successful reperfusion therapy was associated with a reduction in the serum concentrations of soluble cell adhesion molecules in patients with AMI.

Authors+Show Affiliations

Department of Cardiology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China. Yinxie@public6.sta.net.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11775266

Citation

Xie, Y, et al. "Soluble Cell Adhesion Molecules in Patients With Acute Coronary Syndrome." Chinese Medical Journal, vol. 113, no. 3, 2000, pp. 286-8.
Xie Y, Zhou T, Shen W, et al. Soluble cell adhesion molecules in patients with acute coronary syndrome. Chin Med J (Engl). 2000;113(3):286-8.
Xie, Y., Zhou, T., Shen, W., Lu, G., Yin, T., & Gong, L. (2000). Soluble cell adhesion molecules in patients with acute coronary syndrome. Chinese Medical Journal, 113(3), 286-8.
Xie Y, et al. Soluble Cell Adhesion Molecules in Patients With Acute Coronary Syndrome. Chin Med J (Engl). 2000;113(3):286-8. PubMed PMID: 11775266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble cell adhesion molecules in patients with acute coronary syndrome. AU - Xie,Y, AU - Zhou,T, AU - Shen,W, AU - Lu,G, AU - Yin,T, AU - Gong,L, PY - 2002/1/5/pubmed PY - 2002/2/8/medline PY - 2002/1/5/entrez SP - 286 EP - 8 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 113 IS - 3 N2 - OBJECTIVE: To observe the changes in serum soluble intercellular adhesion molecule type-1 (ICAM-1), vascular cell adhesion molecule type-1 (VCAM-1), E-selectin and von Willebrand factor (vWf) in patients with acute coronary syndrome. METHODS: Serial venous blood samples were taken from 21 patients with acute myocardial infarction (AMI) before and 4, 8, 12, 24, 48 and 72 h after thrombolytic treatment or direct PTCA. One blood sample was drawn from 16 patients with unstable angina and 16 control subjects. Serum concentrations of ICAM-1, VCAM-1, E-selectin and vWf were determined using a double antibody sandwich enzyme-linked immunosorbent assay. RESULTS: Serum levels of ICAM-1, VCAM-1, E-selectin and vWf were higher in patients with acute coronary syndrome than in controls. Patients with AMI and successful reperfusion therapy had a significant reduction in the serum concentration of ICAM-1 and E-selectin at 24 and 48 h, VCAM-1 at 24 and 72 h and vWf at 12, 24, 48 and 72 h, but had peak in serum levels of ICAM-1 and E-selectin at 4 h. The number of diseased coronary arteries was not related to the levels of ICAM-1, VCAM-1 and E-selecin. CONCLUSION: The serum concentration of soluble cell adhesion molecules was elevated significantly in patients with acute coronary syndrome. Successful reperfusion therapy was associated with a reduction in the serum concentrations of soluble cell adhesion molecules in patients with AMI. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/11775266/Soluble_cell_adhesion_molecules_in_patients_with_acute_coronary_syndrome_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -