Tags

Type your tag names separated by a space and hit enter

Serum leptin levels after bariatric surgery across a range of glucose tolerance from normal to diabetes.
Obes Surg. 2001 Dec; 11(6):693-8.OS

Abstract

BACKGROUND

A longitudinal, clinical intervention study with bariatric surgery was done to investigate the relationship between leptin levels, BMI, and insulin during weight loss across a range of glucose tolerance from normal to diabetes.

METHODS

43 morbidly obese patients (BMI: 42-75 kg/m2) undergoing vertical banded gastroplasty Roux-en-Y gastric bypass (VBG-RGB), were divided into 3 groups: 21 normal (NGT), 12 impaired glucose tolerance (IGT) and 10 type 2 diabetes (DM). Leptin, insulin, glucose, lipids and uric acid were measured at baseline and 2, 4, 6, and 12 months following surgery.

RESULTS

BMI fell from 54.1 +/- 9.1 to 34.6 +/- 6.3 kg/m2, similarly in all groups. Leptin decreased from 73.9 +/- 8.7 to 16.9 +/- 10.2 ng/ml and was strongly correlated with BMI during 1-year follow-up (r = 0.78; p < 0.001). Linear univariate analysis for repeated evaluation showed a positive correlation between leptin and glucose, triglycerides, uric acid, and insulin. Multivariate regression analysis indicated that BMI was independently correlated with the decrease in leptin (p < 0.001), accounting for 66% of the variance in leptin levels during weight loss. These results were found in the NGT and IGT groups. In the DM group, a small additional influence in leptin levels was attributed to glucose decrease.

CONCLUSIONS

A strong link between leptin and BMI was found after surgery. BMI was the main determinant of the decrease of leptin. In these patients submitted to bariatric surgery, ranging from normal glucose tolerance to diabetes, changes in insulin levels and metabolic parameters, except for glucose in the DM group, did not appear to be correlated with changes in leptin levels.

Authors+Show Affiliations

Endocrinology and Metabolism Service, State University of Campinas, Brazil. bgeloneze@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11775566

Citation

Geloneze, B, et al. "Serum Leptin Levels After Bariatric Surgery Across a Range of Glucose Tolerance From Normal to Diabetes." Obesity Surgery, vol. 11, no. 6, 2001, pp. 693-8.
Geloneze B, Tambascia MA, Pareja JC, et al. Serum leptin levels after bariatric surgery across a range of glucose tolerance from normal to diabetes. Obes Surg. 2001;11(6):693-8.
Geloneze, B., Tambascia, M. A., Pareja, J. C., Repetto, E. M., Magna, L. A., & Pereira, S. G. (2001). Serum leptin levels after bariatric surgery across a range of glucose tolerance from normal to diabetes. Obesity Surgery, 11(6), 693-8.
Geloneze B, et al. Serum Leptin Levels After Bariatric Surgery Across a Range of Glucose Tolerance From Normal to Diabetes. Obes Surg. 2001;11(6):693-8. PubMed PMID: 11775566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum leptin levels after bariatric surgery across a range of glucose tolerance from normal to diabetes. AU - Geloneze,B, AU - Tambascia,M A, AU - Pareja,J C, AU - Repetto,E M, AU - Magna,L A, AU - Pereira,S G, PY - 2002/1/5/pubmed PY - 2002/5/1/medline PY - 2002/1/5/entrez SP - 693 EP - 8 JF - Obesity surgery JO - Obes Surg VL - 11 IS - 6 N2 - BACKGROUND: A longitudinal, clinical intervention study with bariatric surgery was done to investigate the relationship between leptin levels, BMI, and insulin during weight loss across a range of glucose tolerance from normal to diabetes. METHODS: 43 morbidly obese patients (BMI: 42-75 kg/m2) undergoing vertical banded gastroplasty Roux-en-Y gastric bypass (VBG-RGB), were divided into 3 groups: 21 normal (NGT), 12 impaired glucose tolerance (IGT) and 10 type 2 diabetes (DM). Leptin, insulin, glucose, lipids and uric acid were measured at baseline and 2, 4, 6, and 12 months following surgery. RESULTS: BMI fell from 54.1 +/- 9.1 to 34.6 +/- 6.3 kg/m2, similarly in all groups. Leptin decreased from 73.9 +/- 8.7 to 16.9 +/- 10.2 ng/ml and was strongly correlated with BMI during 1-year follow-up (r = 0.78; p < 0.001). Linear univariate analysis for repeated evaluation showed a positive correlation between leptin and glucose, triglycerides, uric acid, and insulin. Multivariate regression analysis indicated that BMI was independently correlated with the decrease in leptin (p < 0.001), accounting for 66% of the variance in leptin levels during weight loss. These results were found in the NGT and IGT groups. In the DM group, a small additional influence in leptin levels was attributed to glucose decrease. CONCLUSIONS: A strong link between leptin and BMI was found after surgery. BMI was the main determinant of the decrease of leptin. In these patients submitted to bariatric surgery, ranging from normal glucose tolerance to diabetes, changes in insulin levels and metabolic parameters, except for glucose in the DM group, did not appear to be correlated with changes in leptin levels. SN - 0960-8923 UR - https://www.unboundmedicine.com/medline/citation/11775566/Serum_leptin_levels_after_bariatric_surgery_across_a_range_of_glucose_tolerance_from_normal_to_diabetes_ L2 - https://dx.doi.org/10.1381/09608920160558623 DB - PRIME DP - Unbound Medicine ER -