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[Changes of the activities of ET-1 in the serum and BALF of ILD patients and their clinical significance].
Zhonghua Jie He He Hu Xi Za Zhi. 1999 Jul; 22(7):411-3.ZJ

Abstract

OBJECTIVE

To evaluate the roles of the Endothelin-1 (ET-1) in pathogenesis of the patients with interstitial lung disease (ILD).

METHODS

The ET-1 activities in the serum and BALF from 10 patients with sarcoidosis, 7 with idiopathic pulmonary fibrosis (IPF) and 8 normal subjects non-smokers were determined using the radio-immunoassay.

RESULTS

In the activities of ET-1 in the serum and BALF in the patients with sarcoiosis (62 +/- 29 and 17.0 +/- 2.4) ng/L and in the IPF (77 +/- 71 and 10 +/- 3) ng/L. was higher than those in the normal control subjects (20 +/- 8 and 4.0 +/- 0.6) ng/L. The activities of ET-1 in serum was negative correlated with PaO2 (r = -0.538, P < 0.01). The level of ET-1 in the BALF of the patient was positive correlated with total cells in BALF (r = 0.649, P < 0.01). The levels of ET-1 in the BALF in the sarcoidosis was positive correlated with the percentage of lymphocyte (r = 0.712, P < 0.01) but in patients with IPF was positive correlated with the percentage of neutrophil (r = 0.813, P < 0.01).

CONCLUSIONS

ET-1 might play an important role in pathogenic of the patients with sarcoidosis and IPF. The levels of ET-1 can act as the markers of activity of disease.

Authors+Show Affiliations

Li Z
Institute of the Respiratory Disease, China Medical University, Shenyang 110001.
Xia S
No affiliation info available
Hou X
No affiliation info available

MeSH

AdultBronchoalveolar Lavage FluidCell CountEndothelin-1FemaleHumansLymphocytesMaleMiddle AgedNeutrophilsPulmonary FibrosisSarcoidosis, Pulmonary

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11775813

Citation

Li, Z, et al. "[Changes of the Activities of ET-1 in the Serum and BALF of ILD Patients and Their Clinical Significance]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 22, no. 7, 1999, pp. 411-3.
Li Z, Xia S, Hou X. [Changes of the activities of ET-1 in the serum and BALF of ILD patients and their clinical significance]. Zhonghua Jie He He Hu Xi Za Zhi. 1999;22(7):411-3.
Li, Z., Xia, S., & Hou, X. (1999). [Changes of the activities of ET-1 in the serum and BALF of ILD patients and their clinical significance]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 22(7), 411-3.
Li Z, Xia S, Hou X. [Changes of the Activities of ET-1 in the Serum and BALF of ILD Patients and Their Clinical Significance]. Zhonghua Jie He He Hu Xi Za Zhi. 1999;22(7):411-3. PubMed PMID: 11775813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Changes of the activities of ET-1 in the serum and BALF of ILD patients and their clinical significance]. AU - Li,Z, AU - Xia,S, AU - Hou,X, PY - 2002/1/5/pubmed PY - 2002/2/1/medline PY - 2002/1/5/entrez SP - 411 EP - 3 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 22 IS - 7 N2 - OBJECTIVE: To evaluate the roles of the Endothelin-1 (ET-1) in pathogenesis of the patients with interstitial lung disease (ILD). METHODS: The ET-1 activities in the serum and BALF from 10 patients with sarcoidosis, 7 with idiopathic pulmonary fibrosis (IPF) and 8 normal subjects non-smokers were determined using the radio-immunoassay. RESULTS: In the activities of ET-1 in the serum and BALF in the patients with sarcoiosis (62 +/- 29 and 17.0 +/- 2.4) ng/L and in the IPF (77 +/- 71 and 10 +/- 3) ng/L. was higher than those in the normal control subjects (20 +/- 8 and 4.0 +/- 0.6) ng/L. The activities of ET-1 in serum was negative correlated with PaO2 (r = -0.538, P < 0.01). The level of ET-1 in the BALF of the patient was positive correlated with total cells in BALF (r = 0.649, P < 0.01). The levels of ET-1 in the BALF in the sarcoidosis was positive correlated with the percentage of lymphocyte (r = 0.712, P < 0.01) but in patients with IPF was positive correlated with the percentage of neutrophil (r = 0.813, P < 0.01). CONCLUSIONS: ET-1 might play an important role in pathogenic of the patients with sarcoidosis and IPF. The levels of ET-1 can act as the markers of activity of disease. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/11775813/[Changes_of_the_activities_of_ET_1_in_the_serum_and_BALF_of_ILD_patients_and_their_clinical_significance]_ L2 - https://medlineplus.gov/pulmonaryfibrosis.html DB - PRIME DP - Unbound Medicine ER -