Tags

Type your tag names separated by a space and hit enter

[Changes of the activities of ET-1 in the serum and BALF of ILD patients and their clinical significance].
Zhonghua Jie He He Hu Xi Za Zhi. 1999 Jul; 22(7):411-3.ZJ

Abstract

OBJECTIVE

To evaluate the roles of the Endothelin-1 (ET-1) in pathogenesis of the patients with interstitial lung disease (ILD).

METHODS

The ET-1 activities in the serum and BALF from 10 patients with sarcoidosis, 7 with idiopathic pulmonary fibrosis (IPF) and 8 normal subjects non-smokers were determined using the radio-immunoassay.

RESULTS

In the activities of ET-1 in the serum and BALF in the patients with sarcoiosis (62 +/- 29 and 17.0 +/- 2.4) ng/L and in the IPF (77 +/- 71 and 10 +/- 3) ng/L. was higher than those in the normal control subjects (20 +/- 8 and 4.0 +/- 0.6) ng/L. The activities of ET-1 in serum was negative correlated with PaO2 (r = -0.538, P < 0.01). The level of ET-1 in the BALF of the patient was positive correlated with total cells in BALF (r = 0.649, P < 0.01). The levels of ET-1 in the BALF in the sarcoidosis was positive correlated with the percentage of lymphocyte (r = 0.712, P < 0.01) but in patients with IPF was positive correlated with the percentage of neutrophil (r = 0.813, P < 0.01).

CONCLUSIONS

ET-1 might play an important role in pathogenic of the patients with sarcoidosis and IPF. The levels of ET-1 can act as the markers of activity of disease.

Authors+Show Affiliations

Institute of the Respiratory Disease, China Medical University, Shenyang 110001.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11775813

Citation

Li, Z, et al. "[Changes of the Activities of ET-1 in the Serum and BALF of ILD Patients and Their Clinical Significance]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 22, no. 7, 1999, pp. 411-3.
Li Z, Xia S, Hou X. [Changes of the activities of ET-1 in the serum and BALF of ILD patients and their clinical significance]. Zhonghua Jie He He Hu Xi Za Zhi. 1999;22(7):411-3.
Li, Z., Xia, S., & Hou, X. (1999). [Changes of the activities of ET-1 in the serum and BALF of ILD patients and their clinical significance]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 22(7), 411-3.
Li Z, Xia S, Hou X. [Changes of the Activities of ET-1 in the Serum and BALF of ILD Patients and Their Clinical Significance]. Zhonghua Jie He He Hu Xi Za Zhi. 1999;22(7):411-3. PubMed PMID: 11775813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Changes of the activities of ET-1 in the serum and BALF of ILD patients and their clinical significance]. AU - Li,Z, AU - Xia,S, AU - Hou,X, PY - 2002/1/5/pubmed PY - 2002/2/1/medline PY - 2002/1/5/entrez SP - 411 EP - 3 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 22 IS - 7 N2 - OBJECTIVE: To evaluate the roles of the Endothelin-1 (ET-1) in pathogenesis of the patients with interstitial lung disease (ILD). METHODS: The ET-1 activities in the serum and BALF from 10 patients with sarcoidosis, 7 with idiopathic pulmonary fibrosis (IPF) and 8 normal subjects non-smokers were determined using the radio-immunoassay. RESULTS: In the activities of ET-1 in the serum and BALF in the patients with sarcoiosis (62 +/- 29 and 17.0 +/- 2.4) ng/L and in the IPF (77 +/- 71 and 10 +/- 3) ng/L. was higher than those in the normal control subjects (20 +/- 8 and 4.0 +/- 0.6) ng/L. The activities of ET-1 in serum was negative correlated with PaO2 (r = -0.538, P < 0.01). The level of ET-1 in the BALF of the patient was positive correlated with total cells in BALF (r = 0.649, P < 0.01). The levels of ET-1 in the BALF in the sarcoidosis was positive correlated with the percentage of lymphocyte (r = 0.712, P < 0.01) but in patients with IPF was positive correlated with the percentage of neutrophil (r = 0.813, P < 0.01). CONCLUSIONS: ET-1 might play an important role in pathogenic of the patients with sarcoidosis and IPF. The levels of ET-1 can act as the markers of activity of disease. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/11775813/[Changes_of_the_activities_of_ET_1_in_the_serum_and_BALF_of_ILD_patients_and_their_clinical_significance]_ L2 - https://medlineplus.gov/pulmonaryfibrosis.html DB - PRIME DP - Unbound Medicine ER -