TY - JOUR T1 - [Expression of bcl-2 protein in adenomyosis]. AU - Zhang,L, AU - Li,J, AU - Li,M, PY - 2002/1/5/pubmed PY - 2002/1/31/medline PY - 2002/1/5/entrez SP - 533 EP - 5 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 35 IS - 9 N2 - OBJECTIVE: To investigate the expression of B cell lymphoma/leukemia-2 (Bcl-2) protein in adenomyosis and its clinical implication. METHODS: Endometrium specimens were obtained from 16 normal uterus and 32 with adenomyosis. bcl-2 expression in these paraffin embraced specimens was examined by immunohistochemical technique with specific monoclonal antibodies. RESULTS: bcl-2 expression in normal endometrium showed a significant cyclic variation. bcl-2 expression of glandular cells in both eutopic and ectopic endometrium of adenomyosis also showed a significant cyclic variation. bcl-2 expression in endometrium of adenomyosis was stronger than that in normal endometrium, and bcl-2 expression in ectopic endometrium was stronger than that in eutopic endometrium. CONCLUSION: The decrease of cellular apoptosis resulted from the high bcl-2 expression may play an important role in the pathogenesis of adenomyosis. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/11775943/[Expression_of_bcl_2_protein_in_adenomyosis]_ L2 - http://www.diseaseinfosearch.org/result/226 DB - PRIME DP - Unbound Medicine ER -