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Association of coagulation factor VII with the risk of myocardial infarction in the Chinese.
Chin Med J (Engl). 2000 Dec; 113(12):1059-63.CM

Abstract

OBJECTIVE

To elucidate the association of plasma factor VII coagulant activity (FVIIc) with the risk of myocardial infarction (MI) and to assess the influence of factor VII gene MspI polymorphism and lipid metabolism on FVIIc in the Chinese.

METHODS

A total of 137 patients with angiographically confirmed MI and 125 healthy individuals were evaluated retrospectively. Plasma FVIIc was measured by one-stage prothrombin time, and FVII genotype was determined after MspI digestion of polymerase chain reaction-amplified genomic DNA. Serum lipid levels were assessed by routine methods.

RESULTS

MI patients had significantly higher levels of FVIIc (119.5% +/- 22.7% vs 99.9% +/- 21.8%, P < 0.01) and total serum cholesterol (5.80 +/- 1.06 mmol/L vs 5.53 +/- 1.08 mmol/L, P < 0.05) than controls, but only FVIIc independently correlated with the risk of MI (OR = 1.04, P < 0.01). There were no significant differences in FVII genotype or allele frequency between patients and controls (P > 0.05). Subjects with the Gln353 allele were associated with significantly lower FVIIc levels than Arg353 homozygotes (99.7% +/- 19.3% vs 111.4% +/- 24.6%, P < 0.05). Serum triglyceride was positively correlated with plasma FVIIc in both control (r = 0.25, P < 0.01) and case (r = 0.87, P < 0.01) groups, but this correlation was restricted to Arg/Arg genotype (r = 0.68, P < 0.01). A significant correlation of total serum cholesterol with FVIIc only appeared in Arg/Arg homozygotes (r = 0.17, P < 0.01).

CONCLUSIONS

Our findings support the role of plasma FVIIc as a risk factor for MI in Chinese. Plasma triglyceride and FVII gene MspI polymorphism are two independent determinants of FVIIc. Assay of this polymorphism will be helpful in determining who will benefit most from lipid-lowing therapy.

Authors+Show Affiliations

Division of Coronary Heart Disease, Cardiovascular Institute, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China. qiangjuncai@263.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11776135

Citation

Cai, Q, et al. "Association of Coagulation Factor VII With the Risk of Myocardial Infarction in the Chinese." Chinese Medical Journal, vol. 113, no. 12, 2000, pp. 1059-63.
Cai Q, Chen J, Ma H, et al. Association of coagulation factor VII with the risk of myocardial infarction in the Chinese. Chin Med J (Engl). 2000;113(12):1059-63.
Cai, Q., Chen, J., Ma, H., Song, J., & Xu, M. (2000). Association of coagulation factor VII with the risk of myocardial infarction in the Chinese. Chinese Medical Journal, 113(12), 1059-63.
Cai Q, et al. Association of Coagulation Factor VII With the Risk of Myocardial Infarction in the Chinese. Chin Med J (Engl). 2000;113(12):1059-63. PubMed PMID: 11776135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of coagulation factor VII with the risk of myocardial infarction in the Chinese. AU - Cai,Q, AU - Chen,J, AU - Ma,H, AU - Song,J, AU - Xu,M, PY - 2002/1/5/pubmed PY - 2002/1/31/medline PY - 2002/1/5/entrez SP - 1059 EP - 63 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 113 IS - 12 N2 - OBJECTIVE: To elucidate the association of plasma factor VII coagulant activity (FVIIc) with the risk of myocardial infarction (MI) and to assess the influence of factor VII gene MspI polymorphism and lipid metabolism on FVIIc in the Chinese. METHODS: A total of 137 patients with angiographically confirmed MI and 125 healthy individuals were evaluated retrospectively. Plasma FVIIc was measured by one-stage prothrombin time, and FVII genotype was determined after MspI digestion of polymerase chain reaction-amplified genomic DNA. Serum lipid levels were assessed by routine methods. RESULTS: MI patients had significantly higher levels of FVIIc (119.5% +/- 22.7% vs 99.9% +/- 21.8%, P < 0.01) and total serum cholesterol (5.80 +/- 1.06 mmol/L vs 5.53 +/- 1.08 mmol/L, P < 0.05) than controls, but only FVIIc independently correlated with the risk of MI (OR = 1.04, P < 0.01). There were no significant differences in FVII genotype or allele frequency between patients and controls (P > 0.05). Subjects with the Gln353 allele were associated with significantly lower FVIIc levels than Arg353 homozygotes (99.7% +/- 19.3% vs 111.4% +/- 24.6%, P < 0.05). Serum triglyceride was positively correlated with plasma FVIIc in both control (r = 0.25, P < 0.01) and case (r = 0.87, P < 0.01) groups, but this correlation was restricted to Arg/Arg genotype (r = 0.68, P < 0.01). A significant correlation of total serum cholesterol with FVIIc only appeared in Arg/Arg homozygotes (r = 0.17, P < 0.01). CONCLUSIONS: Our findings support the role of plasma FVIIc as a risk factor for MI in Chinese. Plasma triglyceride and FVII gene MspI polymorphism are two independent determinants of FVIIc. Assay of this polymorphism will be helpful in determining who will benefit most from lipid-lowing therapy. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/11776135/Association_of_coagulation_factor_VII_with_the_risk_of_myocardial_infarction_in_the_Chinese_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -