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[Expression of multidrug resistance-associated protein (MRP) and lung resistance protein (LRP) in human rectal carcinomas and its clinical significance].
Zhonghua Zhong Liu Za Zhi. 1999 May; 21(3):193-5.ZZ

Abstract

OBJECTIVE

To investigate the expression and clinical significance of multidrug resistance-associated protein(MRP) and lung resistance protein(LRP) in rectal carcinoma.

METHODS

Fiftyseven paraffin embeded primary rectal carcinoma specimens were examined by immunohistochemical staining.

RESULTS

Of the 57 tumour specimens examined, 28(49.1%) and 24(42.1%) were positively immunostaned for MRP and LRP, respectively. Co-expression of the two proteins was observed in 10(17.5%) specimens. Positive immunostaning of either of the two proteins was not correlated with cell differentiation and Dukes stage (P > 0.05). Patients with MRP-positive tumours had shorter survival than MRP-negative patients (P < 0.05). No such correlation was found for LRP expression, nor was found between MRP and LRP expression.

CONCLUSION

Positive MRP expression in rectal carcinoma appears to be an independant factor of prognostic significance. To examine its expression may help guide rational comprehensive therapy of rectal carcinoma.

Authors+Show Affiliations

Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11776833

Citation

Peng, X, et al. "[Expression of Multidrug Resistance-associated Protein (MRP) and Lung Resistance Protein (LRP) in Human Rectal Carcinomas and Its Clinical Significance]." Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], vol. 21, no. 3, 1999, pp. 193-5.
Peng X, Feng F, Zhang W. [Expression of multidrug resistance-associated protein (MRP) and lung resistance protein (LRP) in human rectal carcinomas and its clinical significance]. Zhonghua Zhong Liu Za Zhi. 1999;21(3):193-5.
Peng, X., Feng, F., & Zhang, W. (1999). [Expression of multidrug resistance-associated protein (MRP) and lung resistance protein (LRP) in human rectal carcinomas and its clinical significance]. Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], 21(3), 193-5.
Peng X, Feng F, Zhang W. [Expression of Multidrug Resistance-associated Protein (MRP) and Lung Resistance Protein (LRP) in Human Rectal Carcinomas and Its Clinical Significance]. Zhonghua Zhong Liu Za Zhi. 1999;21(3):193-5. PubMed PMID: 11776833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression of multidrug resistance-associated protein (MRP) and lung resistance protein (LRP) in human rectal carcinomas and its clinical significance]. AU - Peng,X, AU - Feng,F, AU - Zhang,W, PY - 2002/1/5/pubmed PY - 2002/1/31/medline PY - 2002/1/5/entrez SP - 193 EP - 5 JF - Zhonghua zhong liu za zhi [Chinese journal of oncology] JO - Zhonghua Zhong Liu Za Zhi VL - 21 IS - 3 N2 - OBJECTIVE: To investigate the expression and clinical significance of multidrug resistance-associated protein(MRP) and lung resistance protein(LRP) in rectal carcinoma. METHODS: Fiftyseven paraffin embeded primary rectal carcinoma specimens were examined by immunohistochemical staining. RESULTS: Of the 57 tumour specimens examined, 28(49.1%) and 24(42.1%) were positively immunostaned for MRP and LRP, respectively. Co-expression of the two proteins was observed in 10(17.5%) specimens. Positive immunostaning of either of the two proteins was not correlated with cell differentiation and Dukes stage (P > 0.05). Patients with MRP-positive tumours had shorter survival than MRP-negative patients (P < 0.05). No such correlation was found for LRP expression, nor was found between MRP and LRP expression. CONCLUSION: Positive MRP expression in rectal carcinoma appears to be an independant factor of prognostic significance. To examine its expression may help guide rational comprehensive therapy of rectal carcinoma. SN - 0253-3766 UR - https://www.unboundmedicine.com/medline/citation/11776833/[Expression_of_multidrug_resistance_associated_protein__MRP__and_lung_resistance_protein__LRP__in_human_rectal_carcinomas_and_its_clinical_significance]_ DB - PRIME DP - Unbound Medicine ER -