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Association between Helicobacter pylori infection and the risk of gastric cancer in the Korean population: prospective case-controlled study.
J Gastroenterol. 2001 Dec; 36(12):816-22.JG

Abstract

BACKGROUND

Gastric cancer is still the most common malignant tumor in Koreans. Although many reports have supported the association of Helicobacter pylori infection and the development of gastric cancer, few studies have been adjusted by variable factors such as age. sex, education, and economic status. Furthermore, most results from areas with a high incidence of gastric cancer, such as China and Korea, have failed to document any relationship between H. pylori infection and gastric cancer. We conducted a prospective case-controlled study, with controls matched for and adjusted by age, sex, education, and economic status, to evaluate the causal relationship between H. pylori infection and gastric cancer in Korean people.

METHODS

From March 1997 to October 1998, 136 consecutive patients with gastric cancer, diagnosed by endoscopic histology, and 136 age- and sex-matched control subjects, confirmed to be free of gastric cancer by endoscopy during the same period, were enrolled in the study. The presence of H. pylori infection was determined by enzyme immunoassay (EIA) serology test.

RESULTS

Seventy-two of the 136 gastric cancer patients (53%) were positive for H. pylori infection and 54 of the 136 control subjects (40%) were positive for H. pylori infection. The odds ratio (OR), adjusted by variable risk factors, such as age, sex, education, and economic status, for gastric cancer in H. pylori-infected patients was 1.82 (95% confidence internal [CI], 1.10-3.00; P = 0.019). The age- and sex-matched OR by conditional logistic regression was 1.6 (95% CI., 1.01-2.53; P = 0.043).

CONCLUSIONS

H. pylori infection may be one of the important risk factors for the development of gastric cancer in Korea, an area of high prevalence of H. pylori infection and a high incidence of gastric cancer.

Authors+Show Affiliations

Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11777209

Citation

Chang, W K., et al. "Association Between Helicobacter Pylori Infection and the Risk of Gastric Cancer in the Korean Population: Prospective Case-controlled Study." Journal of Gastroenterology, vol. 36, no. 12, 2001, pp. 816-22.
Chang WK, Kim HY, Kim DJ, et al. Association between Helicobacter pylori infection and the risk of gastric cancer in the Korean population: prospective case-controlled study. J Gastroenterol. 2001;36(12):816-22.
Chang, W. K., Kim, H. Y., Kim, D. J., Lee, J., Park, C. K., Yoo, J. Y., Kim, H. J., Kim, M. K., Choi, B. Y., Choi, H. S., & Park, K. N. (2001). Association between Helicobacter pylori infection and the risk of gastric cancer in the Korean population: prospective case-controlled study. Journal of Gastroenterology, 36(12), 816-22.
Chang WK, et al. Association Between Helicobacter Pylori Infection and the Risk of Gastric Cancer in the Korean Population: Prospective Case-controlled Study. J Gastroenterol. 2001;36(12):816-22. PubMed PMID: 11777209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Helicobacter pylori infection and the risk of gastric cancer in the Korean population: prospective case-controlled study. AU - Chang,W K, AU - Kim,H Y, AU - Kim,D J, AU - Lee,J, AU - Park,C K, AU - Yoo,J Y, AU - Kim,H J, AU - Kim,M K, AU - Choi,B Y, AU - Choi,H S, AU - Park,K N, PY - 2002/1/5/pubmed PY - 2002/3/8/medline PY - 2002/1/5/entrez SP - 816 EP - 22 JF - Journal of gastroenterology JO - J. Gastroenterol. VL - 36 IS - 12 N2 - BACKGROUND: Gastric cancer is still the most common malignant tumor in Koreans. Although many reports have supported the association of Helicobacter pylori infection and the development of gastric cancer, few studies have been adjusted by variable factors such as age. sex, education, and economic status. Furthermore, most results from areas with a high incidence of gastric cancer, such as China and Korea, have failed to document any relationship between H. pylori infection and gastric cancer. We conducted a prospective case-controlled study, with controls matched for and adjusted by age, sex, education, and economic status, to evaluate the causal relationship between H. pylori infection and gastric cancer in Korean people. METHODS: From March 1997 to October 1998, 136 consecutive patients with gastric cancer, diagnosed by endoscopic histology, and 136 age- and sex-matched control subjects, confirmed to be free of gastric cancer by endoscopy during the same period, were enrolled in the study. The presence of H. pylori infection was determined by enzyme immunoassay (EIA) serology test. RESULTS: Seventy-two of the 136 gastric cancer patients (53%) were positive for H. pylori infection and 54 of the 136 control subjects (40%) were positive for H. pylori infection. The odds ratio (OR), adjusted by variable risk factors, such as age, sex, education, and economic status, for gastric cancer in H. pylori-infected patients was 1.82 (95% confidence internal [CI], 1.10-3.00; P = 0.019). The age- and sex-matched OR by conditional logistic regression was 1.6 (95% CI., 1.01-2.53; P = 0.043). CONCLUSIONS: H. pylori infection may be one of the important risk factors for the development of gastric cancer in Korea, an area of high prevalence of H. pylori infection and a high incidence of gastric cancer. SN - 0944-1174 UR - https://www.unboundmedicine.com/medline/citation/11777209/Association_between_Helicobacter_pylori_infection_and_the_risk_of_gastric_cancer_in_the_Korean_population:_prospective_case_controlled_study_ L2 - https://dx.doi.org/10.1007/s005350170003 DB - PRIME DP - Unbound Medicine ER -