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[The significance of detecting tumor necrosis factor-alpha and its receptors in serum and pleural effusion in differentiating tuberculosis and malignant pleural effusions].
Zhonghua Jie He He Hu Xi Za Zhi. 2000 Mar; 23(3):158-60.ZJ

Abstract

OBJECTIVE

To investigate the significance of TNF-alpha and its soluble receptors (sTNFR-I and sTNFR-II) in differentiating benign and malignant pleural disease.

METHODS

TNF-alpha and its soluble receptors (sTNFR-I and sTNFR-II) were detected using ELISA method in the serum and pleural effusion of 25 cases of tuberculosis pleural effusion and 28 cases of malignant pleural effusion, and in the serum of 32 cases of normal control.

RESULTS

TNF-alpha level in the serum of tuberculosis patients with pleural effusion is (16.4 +/- 6.2) ng/L, lower than that in the serum of malignant pleural effusion patients (20.5 +/- 10.9) ng/L (P < 0.01), but higher than that in the serum of normal control (11.0 +/- 2.9) ng/L (P < 0.01). TNF-alpha level in the pleural effusion of tuberculosis patients is (29.4 +/- 10.3) ng/L, significantly higher than that of malignant pleural effusion (11.7 +/- 2.0) ng/L (P < 0.01). The sTNFR-I and sTNFR-II level in the serum of malignant pleural effusion is (1,132 +/- 303) ng/L and (1,548 +/- 489) ng/L respectively, significantly higher than that in tuberculosis pleural effusion which is (979 +/- 146) ng/L and (977 +/- 93) ng/L (P < 0.01) respectively. The sTNFR-I and sTNFR-II level in malignant pleural effusion is (1,404 +/- 306) ng/L and (2,195 +/- 418) ng/L respectively, markedly higher than those in tuberculosis pleural effusion which is (1,185 +/- 215) ng/L and (1,195 +/- 300) ng/L (P < 0.01).

CONCLUSION

There are highly elevated TNF-alpha in tuberculosis pleural effusion; The sTNFR-I and sTNFR-II level in the serum and pleural effusion of malignant pleural effusion patients are significantly higher than those in tuberculosis pleural effusion patients, suggesting they may play some role in differentiating benign and malignant pleural diseases.

Authors+Show Affiliations

Zhou J
1st Affiliated Hospital of Medical School, Zhejiang University, Hangzhou 310003, China.
Zhao Q
No affiliation info available
Yao H
No affiliation info available

MeSH

AdultAgedAntigens, CDDiagnosis, DifferentialFemaleHumansMaleMiddle AgedPleural EffusionPleural Effusion, MalignantReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IITuberculosis, PleuralTumor Necrosis Factor-alpha

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11778489

Citation

Zhou, J, et al. "[The Significance of Detecting Tumor Necrosis Factor-alpha and Its Receptors in Serum and Pleural Effusion in Differentiating Tuberculosis and Malignant Pleural Effusions]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 23, no. 3, 2000, pp. 158-60.
Zhou J, Zhao Q, Yao H. [The significance of detecting tumor necrosis factor-alpha and its receptors in serum and pleural effusion in differentiating tuberculosis and malignant pleural effusions]. Zhonghua Jie He He Hu Xi Za Zhi. 2000;23(3):158-60.
Zhou, J., Zhao, Q., & Yao, H. (2000). [The significance of detecting tumor necrosis factor-alpha and its receptors in serum and pleural effusion in differentiating tuberculosis and malignant pleural effusions]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 23(3), 158-60.
Zhou J, Zhao Q, Yao H. [The Significance of Detecting Tumor Necrosis Factor-alpha and Its Receptors in Serum and Pleural Effusion in Differentiating Tuberculosis and Malignant Pleural Effusions]. Zhonghua Jie He He Hu Xi Za Zhi. 2000;23(3):158-60. PubMed PMID: 11778489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The significance of detecting tumor necrosis factor-alpha and its receptors in serum and pleural effusion in differentiating tuberculosis and malignant pleural effusions]. AU - Zhou,J, AU - Zhao,Q, AU - Yao,H, PY - 2002/1/10/pubmed PY - 2002/1/31/medline PY - 2002/1/10/entrez SP - 158 EP - 60 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 23 IS - 3 N2 - OBJECTIVE: To investigate the significance of TNF-alpha and its soluble receptors (sTNFR-I and sTNFR-II) in differentiating benign and malignant pleural disease. METHODS: TNF-alpha and its soluble receptors (sTNFR-I and sTNFR-II) were detected using ELISA method in the serum and pleural effusion of 25 cases of tuberculosis pleural effusion and 28 cases of malignant pleural effusion, and in the serum of 32 cases of normal control. RESULTS: TNF-alpha level in the serum of tuberculosis patients with pleural effusion is (16.4 +/- 6.2) ng/L, lower than that in the serum of malignant pleural effusion patients (20.5 +/- 10.9) ng/L (P < 0.01), but higher than that in the serum of normal control (11.0 +/- 2.9) ng/L (P < 0.01). TNF-alpha level in the pleural effusion of tuberculosis patients is (29.4 +/- 10.3) ng/L, significantly higher than that of malignant pleural effusion (11.7 +/- 2.0) ng/L (P < 0.01). The sTNFR-I and sTNFR-II level in the serum of malignant pleural effusion is (1,132 +/- 303) ng/L and (1,548 +/- 489) ng/L respectively, significantly higher than that in tuberculosis pleural effusion which is (979 +/- 146) ng/L and (977 +/- 93) ng/L (P < 0.01) respectively. The sTNFR-I and sTNFR-II level in malignant pleural effusion is (1,404 +/- 306) ng/L and (2,195 +/- 418) ng/L respectively, markedly higher than those in tuberculosis pleural effusion which is (1,185 +/- 215) ng/L and (1,195 +/- 300) ng/L (P < 0.01). CONCLUSION: There are highly elevated TNF-alpha in tuberculosis pleural effusion; The sTNFR-I and sTNFR-II level in the serum and pleural effusion of malignant pleural effusion patients are significantly higher than those in tuberculosis pleural effusion patients, suggesting they may play some role in differentiating benign and malignant pleural diseases. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/11778489/[The_significance_of_detecting_tumor_necrosis_factor_alpha_and_its_receptors_in_serum_and_pleural_effusion_in_differentiating_tuberculosis_and_malignant_pleural_effusions]_ L2 - https://www.diseaseinfosearch.org/result/7252 DB - PRIME DP - Unbound Medicine ER -