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[The role of platelet activation in the pathogenesis of asthma].
Zhonghua Jie He He Hu Xi Za Zhi. 2000 Jun; 23(6):343-6.ZJ

Abstract

OBJECTIVE

To investigate whether platelets are activated during an asthmatic attack and to detect the correlation between platelet activation and severity of bronchial asthma.

METHODS

Plasma concentration of thromboxane B2(TXB2) and 11-dehydro-TXB2(11-DH-TXB2) and P-selectin (CD 62P) on platelet surface were measured in 44 patients with asthma and in 18 normal individuals using ELISA and FCP. The serum ECP level and pulmonary function were also analysed.

RESULTS

The plasma level of 11-DH-TXB2 and TXB2 and the positive percentage of CD 62P on platelets were significantly increased in patients with acute asthma (n = 28) as compared with the control (n = 18, P < 0.01). The plasma concentration of 11-DH-TXB2 and TXB2 were decreased significanty after the control of asthma. The level of platelet activation was correlated with ECP (r = 0.785, P < 0.05), FEV1% (r = -0.867, P < 0.01) and PEF(r = -0.745, P < 0.05).

CONCLUSIONS

These results suggest that there is an abnormal platelet activation in asthmatics, which can reflect the severity of bronchial asthma to a certain extent, although its exact, mechanism is unknown. The platelets secret a wide range of biologically active substances capable of inducing or augmenting the airway inflammatory responses in asthma.

Authors+Show Affiliations

Department of Respirology, First Affiliated Hospital, Suzhou Medical College, Suzhou 215006, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11778515

Citation

Heng, W, et al. "[The Role of Platelet Activation in the Pathogenesis of Asthma]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 23, no. 6, 2000, pp. 343-6.
Heng W, Wang G, Wang Z. [The role of platelet activation in the pathogenesis of asthma]. Zhonghua Jie He He Hu Xi Za Zhi. 2000;23(6):343-6.
Heng, W., Wang, G., & Wang, Z. (2000). [The role of platelet activation in the pathogenesis of asthma]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 23(6), 343-6.
Heng W, Wang G, Wang Z. [The Role of Platelet Activation in the Pathogenesis of Asthma]. Zhonghua Jie He He Hu Xi Za Zhi. 2000;23(6):343-6. PubMed PMID: 11778515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The role of platelet activation in the pathogenesis of asthma]. AU - Heng,W, AU - Wang,G, AU - Wang,Z, PY - 2002/1/10/pubmed PY - 2002/3/2/medline PY - 2002/1/10/entrez SP - 343 EP - 6 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 23 IS - 6 N2 - OBJECTIVE: To investigate whether platelets are activated during an asthmatic attack and to detect the correlation between platelet activation and severity of bronchial asthma. METHODS: Plasma concentration of thromboxane B2(TXB2) and 11-dehydro-TXB2(11-DH-TXB2) and P-selectin (CD 62P) on platelet surface were measured in 44 patients with asthma and in 18 normal individuals using ELISA and FCP. The serum ECP level and pulmonary function were also analysed. RESULTS: The plasma level of 11-DH-TXB2 and TXB2 and the positive percentage of CD 62P on platelets were significantly increased in patients with acute asthma (n = 28) as compared with the control (n = 18, P < 0.01). The plasma concentration of 11-DH-TXB2 and TXB2 were decreased significanty after the control of asthma. The level of platelet activation was correlated with ECP (r = 0.785, P < 0.05), FEV1% (r = -0.867, P < 0.01) and PEF(r = -0.745, P < 0.05). CONCLUSIONS: These results suggest that there is an abnormal platelet activation in asthmatics, which can reflect the severity of bronchial asthma to a certain extent, although its exact, mechanism is unknown. The platelets secret a wide range of biologically active substances capable of inducing or augmenting the airway inflammatory responses in asthma. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/11778515/[The_role_of_platelet_activation_in_the_pathogenesis_of_asthma]_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -