TY - JOUR T1 - Treatment of influenza with neuraminidase inhibitors: virological implications. A1 - Roberts,N A, PY - 2002/1/10/pubmed PY - 2002/4/17/medline PY - 2002/1/10/entrez SP - 1895 EP - 7 JF - Philosophical transactions of the Royal Society of London. Series B, Biological sciences JO - Philos Trans R Soc Lond B Biol Sci VL - 356 IS - 1416 N2 - Evaluation of the emergence of influenza virus resistance to neuraminidase inhibitors (NAIs) is now demanded following experience with amantadinamines. Preliminary data have indicated that NAI-resistant virus is unlikely to emerge readily in the clinic and this is consistent with the difficulty experienced in selecting resistant virus in vitro. Resistance mutations can occur in both neuraminidase and haemagglutinin genes. The neuraminidase mutations are viral subtype specific and, therefore, clinically relevant subtypes must be employed for in vitro studies if pre-clinical data are to have predictive value. Haemagglutinin mutations generated in vitro are probably both subtype and cell culture system specific and, therefore, may not be predictive of clinical findings. Analysis of influenza-positive samples from NAI-treated patients in the clinical setting must include samples from late treatment time-points (day 4 and later) in order for resistant virus to be detected as in vitro studies and current clinical experience have indicated that resistant virus is slow to emerge and is transient. SN - 0962-8436 UR - https://www.unboundmedicine.com/medline/citation/11779389/Treatment_of_influenza_with_neuraminidase_inhibitors:_virological_implications_ L2 - https://royalsocietypublishing.org/doi/10.1098/rstb.2001.1002?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -