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Parkinson's disease therapy: treatment of early and late disease.
Chin Med J (Engl). 2001 Mar; 114(3):227-34.CM

Abstract

PURPOSE

To summarize the current strategies for the treatment of early and late Parkinson's disease (PD).

DATA SOURCES

The presented guidelines are based on the review of the literature as well as the author's extensive experience with the treatment of 7000 patients with PD over the past 25 years.

RESULTS

An analysis of reported data as well as personal experience suggest that while young patients seem to have a slower progression of the disease, they are at a higher risk for developing levodopa induced complications, such as motor fluctuations and dyskinesias. It is, therefore, prudent practice to delay levodopa therapy, particularly in younger patients, until the PD symptoms become troublesome and interfere with social or occupational functioning. Other strategies, such as the use of deprenyl, amantadine, trihexphenidyl and dopamine agonists, should be employed before instituting levodopa therapy. Entacopone and dopamine agonists are useful in smoothing out levodopa related motor fluctuations. Surgical interventions, such as pallidotomy and pallidal or subthalamic deep brain stimulation, are effective therapeutic strategies, but should be reserved only for patients in whom optimal medical therapy fails to provide satisfactory control of symptoms.

CONCLUSION

The medical and surgical treatment of patients with PD must be individualized and tailored to the needs of the individual patient.

Authors+Show Affiliations

Baylor College of Medicine, Houston, Texas, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11780303

Citation

Jankovic, J. "Parkinson's Disease Therapy: Treatment of Early and Late Disease." Chinese Medical Journal, vol. 114, no. 3, 2001, pp. 227-34.
Jankovic J. Parkinson's disease therapy: treatment of early and late disease. Chin Med J (Engl). 2001;114(3):227-34.
Jankovic, J. (2001). Parkinson's disease therapy: treatment of early and late disease. Chinese Medical Journal, 114(3), 227-34.
Jankovic J. Parkinson's Disease Therapy: Treatment of Early and Late Disease. Chin Med J (Engl). 2001;114(3):227-34. PubMed PMID: 11780303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parkinson's disease therapy: treatment of early and late disease. A1 - Jankovic,J, PY - 2002/1/10/pubmed PY - 2002/2/14/medline PY - 2002/1/10/entrez SP - 227 EP - 34 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 114 IS - 3 N2 - PURPOSE: To summarize the current strategies for the treatment of early and late Parkinson's disease (PD). DATA SOURCES: The presented guidelines are based on the review of the literature as well as the author's extensive experience with the treatment of 7000 patients with PD over the past 25 years. RESULTS: An analysis of reported data as well as personal experience suggest that while young patients seem to have a slower progression of the disease, they are at a higher risk for developing levodopa induced complications, such as motor fluctuations and dyskinesias. It is, therefore, prudent practice to delay levodopa therapy, particularly in younger patients, until the PD symptoms become troublesome and interfere with social or occupational functioning. Other strategies, such as the use of deprenyl, amantadine, trihexphenidyl and dopamine agonists, should be employed before instituting levodopa therapy. Entacopone and dopamine agonists are useful in smoothing out levodopa related motor fluctuations. Surgical interventions, such as pallidotomy and pallidal or subthalamic deep brain stimulation, are effective therapeutic strategies, but should be reserved only for patients in whom optimal medical therapy fails to provide satisfactory control of symptoms. CONCLUSION: The medical and surgical treatment of patients with PD must be individualized and tailored to the needs of the individual patient. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/11780303/Parkinson's_disease_therapy:_treatment_of_early_and_late_disease_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -