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Apolipoprotein E polymorphism in the early onset of coronary heart disease.
Chin Med J (Engl). 2001 Sep; 114(9):983-5.CM

Abstract

OBJECTIVE

To assess the relationship between apolipoprotein E (apoE) polymorphism and the early onset of coronary heart disease (CHD) and the effect of apoE on lipids and lipoproteins in healthy Chinese subjects.

METHODS

Sixty-eight patients with CHD younger than 55 years (CHD1), 136 patients with CHD older than 65 years (CHD2), and 136 healthy subjects were enrolled, and their plasma levels of triglyceride (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were determined. The apoE genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism.

RESULTS

apoE 3/4 genotype and E4 allele frequency in the CHD1 group were higher than those in the CHD2 group and healthy subjects, while no differences were found between CHD2 and healthy subjects. Meanwhile, the plasma levels of TC and low density lipoprotein cholesterol (LDL-C) were higher in the CHD2 group than in both CHD1 group and healthy subjects. Each apoE isoprotein has variable TC and LDL-C levels that is E2 (E2/2 + E2/3) < E3(E3/3) < E4(E4/4 + E3/4).

CONCLUSION

apoE is one of the genetic factors that affect TC and LDL-C levels, and apoE 4 has a very close relation to CHD, suggesting that apoE 4 is an independent genetic factor of the early onset of CHD.

Authors+Show Affiliations

Department of Cardiology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11780396

Citation

Yang, Z, et al. "Apolipoprotein E Polymorphism in the Early Onset of Coronary Heart Disease." Chinese Medical Journal, vol. 114, no. 9, 2001, pp. 983-5.
Yang Z, Zhu T, Ma G, et al. Apolipoprotein E polymorphism in the early onset of coronary heart disease. Chin Med J. 2001;114(9):983-5.
Yang, Z., Zhu, T., Ma, G., Yin, H., Qian, W., Zhang, F., Cao, K., & Ma, W. (2001). Apolipoprotein E polymorphism in the early onset of coronary heart disease. Chinese Medical Journal, 114(9), 983-5.
Yang Z, et al. Apolipoprotein E Polymorphism in the Early Onset of Coronary Heart Disease. Chin Med J. 2001;114(9):983-5. PubMed PMID: 11780396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E polymorphism in the early onset of coronary heart disease. AU - Yang,Z, AU - Zhu,T, AU - Ma,G, AU - Yin,H, AU - Qian,W, AU - Zhang,F, AU - Cao,K, AU - Ma,W, PY - 2002/1/10/pubmed PY - 2002/2/6/medline PY - 2002/1/10/entrez SP - 983 EP - 5 JF - Chinese medical journal JO - Chin. Med. J. VL - 114 IS - 9 N2 - OBJECTIVE: To assess the relationship between apolipoprotein E (apoE) polymorphism and the early onset of coronary heart disease (CHD) and the effect of apoE on lipids and lipoproteins in healthy Chinese subjects. METHODS: Sixty-eight patients with CHD younger than 55 years (CHD1), 136 patients with CHD older than 65 years (CHD2), and 136 healthy subjects were enrolled, and their plasma levels of triglyceride (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were determined. The apoE genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: apoE 3/4 genotype and E4 allele frequency in the CHD1 group were higher than those in the CHD2 group and healthy subjects, while no differences were found between CHD2 and healthy subjects. Meanwhile, the plasma levels of TC and low density lipoprotein cholesterol (LDL-C) were higher in the CHD2 group than in both CHD1 group and healthy subjects. Each apoE isoprotein has variable TC and LDL-C levels that is E2 (E2/2 + E2/3) < E3(E3/3) < E4(E4/4 + E3/4). CONCLUSION: apoE is one of the genetic factors that affect TC and LDL-C levels, and apoE 4 has a very close relation to CHD, suggesting that apoE 4 is an independent genetic factor of the early onset of CHD. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/11780396/Apolipoprotein_E_polymorphism_in_the_early_onset_of_coronary_heart_disease_ L2 - http://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -