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Placental leptin correlates with intrauterine fetal growth and development.
Chin Med J (Engl) 2001; 114(6):636-9CM

Abstract

OBJECTIVE

To study the role of placental leptin in intrauterine cord leptin production and its relationship with neonatal anthropometry.

METHODS

Forty women and their babies (40) were enrolled in this study. Placental tissues were assayed for leptin mRNA by reverse transcription/polymerase chain reaction (RT/PCR), and assayed for the obese gene protein leptin by Western-blot and immunohistochemistry. Blood was taken from the umbilical cord of the babies at delivery. Serum leptin was measured by radio-immunoassay. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between placental leptin, cord leptin and neonatal anthropometric measures.

RESULTS

The obese gene was expressed in placental tissue at comparable or greater levels than that in adipose tissue. The placentas of the small for gestational age (SGA) neonates expressed leptin mRNA and protein at significantly lower levels than those of the appropriate for gestational age (AGA) neonates (P = 0.0034 and 0.0076), while the placentas of the large for gestational age (LGA) neonates expressed leptin mRNA and protein at significantly higher levels than those of the AGA neonates (P = 0.043 and 0.021). Linear regression analysis showed placental ob gene transcription and leptin translation correlated significantly with cord leptin (r = 0.39 and 0.43), and neonatal Ponderal Index (r = 0.66 and 0.69).

CONCLUSION

The placenta provides a source of leptin for the growing fetus, and this placental leptin might be a growth factor in intrauterine fetal development.

Authors+Show Affiliations

Shanghai Institute of Pediatrics, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China. benxm@etang.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11780443

Citation

Ben, X, et al. "Placental Leptin Correlates With Intrauterine Fetal Growth and Development." Chinese Medical Journal, vol. 114, no. 6, 2001, pp. 636-9.
Ben X, Qin Y, Wu S, et al. Placental leptin correlates with intrauterine fetal growth and development. Chin Med J. 2001;114(6):636-9.
Ben, X., Qin, Y., Wu, S., Zhang, W., & Cai, W. (2001). Placental leptin correlates with intrauterine fetal growth and development. Chinese Medical Journal, 114(6), pp. 636-9.
Ben X, et al. Placental Leptin Correlates With Intrauterine Fetal Growth and Development. Chin Med J. 2001;114(6):636-9. PubMed PMID: 11780443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placental leptin correlates with intrauterine fetal growth and development. AU - Ben,X, AU - Qin,Y, AU - Wu,S, AU - Zhang,W, AU - Cai,W, PY - 2002/1/10/pubmed PY - 2002/2/14/medline PY - 2002/1/10/entrez SP - 636 EP - 9 JF - Chinese medical journal JO - Chin. Med. J. VL - 114 IS - 6 N2 - OBJECTIVE: To study the role of placental leptin in intrauterine cord leptin production and its relationship with neonatal anthropometry. METHODS: Forty women and their babies (40) were enrolled in this study. Placental tissues were assayed for leptin mRNA by reverse transcription/polymerase chain reaction (RT/PCR), and assayed for the obese gene protein leptin by Western-blot and immunohistochemistry. Blood was taken from the umbilical cord of the babies at delivery. Serum leptin was measured by radio-immunoassay. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between placental leptin, cord leptin and neonatal anthropometric measures. RESULTS: The obese gene was expressed in placental tissue at comparable or greater levels than that in adipose tissue. The placentas of the small for gestational age (SGA) neonates expressed leptin mRNA and protein at significantly lower levels than those of the appropriate for gestational age (AGA) neonates (P = 0.0034 and 0.0076), while the placentas of the large for gestational age (LGA) neonates expressed leptin mRNA and protein at significantly higher levels than those of the AGA neonates (P = 0.043 and 0.021). Linear regression analysis showed placental ob gene transcription and leptin translation correlated significantly with cord leptin (r = 0.39 and 0.43), and neonatal Ponderal Index (r = 0.66 and 0.69). CONCLUSION: The placenta provides a source of leptin for the growing fetus, and this placental leptin might be a growth factor in intrauterine fetal development. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/11780443/Placental_leptin_correlates_with_intrauterine_fetal_growth_and_development_ DB - PRIME DP - Unbound Medicine ER -