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CMV monitoring after peripheral blood stem cell and bone marrow transplantation by pp65 antigen and quantitative PCR.
Bone Marrow Transplant. 2001 Oct; 28(8):765-8.BM

Abstract

We prospectively monitored 74 consecutive allogeneic and 50 autologous patients after bone marrow/stem cell transplantation from May 1999 to October 2000 at our institution with quantitative CMV PCR and pp65 antigen assay once weekly from conditioning therapy to days 120 and 80 after transplantation, respectively. Written informed consent was obtained from every patient. CMV prophylaxis consisted of acyclovir during transplant. Additionally all patients received only platelet products from CMV-negative donors. In the case of CMV infection preemptive therapy with gancyclovir was applied. In the case of CMV disease high-dose immunoglobulin was given as well. In the allogeneic setting 16 out of 74 (22%) patients developed a positive PCR. Seven episodes of a positive pp65 antigen assay occurred in six allograft recipients. In the autologous setting no positive assay was found during the whole observation period. Additionally, in 6/16 patients a lymphoproliferative assay was performed during CMV infection. Two patients showed a positive (15 and 5.4) and four a negative (2,1.6,1,1.8) stimulation index.

Authors+Show Affiliations

Department of Medicine I, Bone Marrow Transplantation, University of Vienna, Vienna Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

11781628

Citation

Schulenburg, A, et al. "CMV Monitoring After Peripheral Blood Stem Cell and Bone Marrow Transplantation By Pp65 Antigen and Quantitative PCR." Bone Marrow Transplantation, vol. 28, no. 8, 2001, pp. 765-8.
Schulenburg A, Watkins-Riedel T, Greinix HT, et al. CMV monitoring after peripheral blood stem cell and bone marrow transplantation by pp65 antigen and quantitative PCR. Bone Marrow Transplant. 2001;28(8):765-8.
Schulenburg, A., Watkins-Riedel, T., Greinix, H. T., Rabitsch, W., Loidolt, H., Keil, F., Mitterbauer, M., & Kalhs, P. (2001). CMV monitoring after peripheral blood stem cell and bone marrow transplantation by pp65 antigen and quantitative PCR. Bone Marrow Transplantation, 28(8), 765-8.
Schulenburg A, et al. CMV Monitoring After Peripheral Blood Stem Cell and Bone Marrow Transplantation By Pp65 Antigen and Quantitative PCR. Bone Marrow Transplant. 2001;28(8):765-8. PubMed PMID: 11781628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CMV monitoring after peripheral blood stem cell and bone marrow transplantation by pp65 antigen and quantitative PCR. AU - Schulenburg,A, AU - Watkins-Riedel,T, AU - Greinix,H T, AU - Rabitsch,W, AU - Loidolt,H, AU - Keil,F, AU - Mitterbauer,M, AU - Kalhs,P, PY - 2001/04/17/received PY - 2001/07/15/accepted PY - 2002/1/10/pubmed PY - 2002/3/30/medline PY - 2002/1/10/entrez SP - 765 EP - 8 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 28 IS - 8 N2 - We prospectively monitored 74 consecutive allogeneic and 50 autologous patients after bone marrow/stem cell transplantation from May 1999 to October 2000 at our institution with quantitative CMV PCR and pp65 antigen assay once weekly from conditioning therapy to days 120 and 80 after transplantation, respectively. Written informed consent was obtained from every patient. CMV prophylaxis consisted of acyclovir during transplant. Additionally all patients received only platelet products from CMV-negative donors. In the case of CMV infection preemptive therapy with gancyclovir was applied. In the case of CMV disease high-dose immunoglobulin was given as well. In the allogeneic setting 16 out of 74 (22%) patients developed a positive PCR. Seven episodes of a positive pp65 antigen assay occurred in six allograft recipients. In the autologous setting no positive assay was found during the whole observation period. Additionally, in 6/16 patients a lymphoproliferative assay was performed during CMV infection. Two patients showed a positive (15 and 5.4) and four a negative (2,1.6,1,1.8) stimulation index. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/11781628/CMV_monitoring_after_peripheral_blood_stem_cell_and_bone_marrow_transplantation_by_pp65_antigen_and_quantitative_PCR_ L2 - https://doi.org/10.1038/sj.bmt.1703227 DB - PRIME DP - Unbound Medicine ER -