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Evaluation of nonglucose carbohydrates in parenteral nutrition for diabetic patients.
Eur J Clin Nutr. 2001 Dec; 55(12):1111-6.EJ

Abstract

OBJECTIVE

There is little information on the advantages of nonglucose carbohydrates in total parenteral nutrition (TPN) for diabetic patients. The aim of this study is to evaluate glycemic control and insulin requirements in diabetic patients who received TPN with different sources of carbohydrates, and to determine whether insulin requirements are different when septic and non-septic diabetic patients are studied.

MATERIALS AND METHODS

One-hundred and thirty-eight patients were randomly divided into two groups receiving either glucose (G), n=71, or glucose-fructose-xylitol 2:1:1 (GFX), n=67. There were no differences between the demographic or anthropometric characteristics of the groups, nor between the patients with diabetes mellitus type 1 and type 2, nor the initial TPN composition. Acceptable glycemic control was considered when glycemia reached <200 mg/dl.

RESULTS

Glycemic control was attained in 79.7% of patients (74.6 vs 85.1%), in the same period of treatment. At the end of treatment, insulin requirements were not different (45+/-19 vs 45+/-26 UI/day) in both groups, while similar amounts of carbohydrates (191+/-36 vs 187+/-45 g/day) were infused. The ratio insulin/body weight and insulin/carbohydrates were equal in both groups. In the GFX group nonseptic and septic patients needed less and more insulin, respectively, than their counterparts in the G group. No major adverse events related to carbohydrate infusions were observed.

CONCLUSIONS

Either G or GFX could be used in TPN for diabetic patients, providing glycemic control in most cases with similar insulin requirements. GFX mixtures were slightly more beneficial to attain glycemic control in nonseptic patients, but septic diabetic patients had higher insulin needs in this group.

Authors+Show Affiliations

Clinical Nutrition, Hospital Doce de Octubre, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11781679

Citation

Valero, M A., et al. "Evaluation of Nonglucose Carbohydrates in Parenteral Nutrition for Diabetic Patients." European Journal of Clinical Nutrition, vol. 55, no. 12, 2001, pp. 1111-6.
Valero MA, León-Sanz M, Escobar I, et al. Evaluation of nonglucose carbohydrates in parenteral nutrition for diabetic patients. Eur J Clin Nutr. 2001;55(12):1111-6.
Valero, M. A., León-Sanz, M., Escobar, I., Gomis, P., de la Cámara, A., & Moreno, J. M. (2001). Evaluation of nonglucose carbohydrates in parenteral nutrition for diabetic patients. European Journal of Clinical Nutrition, 55(12), 1111-6.
Valero MA, et al. Evaluation of Nonglucose Carbohydrates in Parenteral Nutrition for Diabetic Patients. Eur J Clin Nutr. 2001;55(12):1111-6. PubMed PMID: 11781679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of nonglucose carbohydrates in parenteral nutrition for diabetic patients. AU - Valero,M A, AU - León-Sanz,M, AU - Escobar,I, AU - Gomis,P, AU - de la Cámara,A, AU - Moreno,J M, PY - 2001/02/09/received PY - 2001/05/17/revised PY - 2001/05/20/accepted PY - 2002/1/10/pubmed PY - 2002/2/7/medline PY - 2002/1/10/entrez SP - 1111 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 55 IS - 12 N2 - OBJECTIVE: There is little information on the advantages of nonglucose carbohydrates in total parenteral nutrition (TPN) for diabetic patients. The aim of this study is to evaluate glycemic control and insulin requirements in diabetic patients who received TPN with different sources of carbohydrates, and to determine whether insulin requirements are different when septic and non-septic diabetic patients are studied. MATERIALS AND METHODS: One-hundred and thirty-eight patients were randomly divided into two groups receiving either glucose (G), n=71, or glucose-fructose-xylitol 2:1:1 (GFX), n=67. There were no differences between the demographic or anthropometric characteristics of the groups, nor between the patients with diabetes mellitus type 1 and type 2, nor the initial TPN composition. Acceptable glycemic control was considered when glycemia reached <200 mg/dl. RESULTS: Glycemic control was attained in 79.7% of patients (74.6 vs 85.1%), in the same period of treatment. At the end of treatment, insulin requirements were not different (45+/-19 vs 45+/-26 UI/day) in both groups, while similar amounts of carbohydrates (191+/-36 vs 187+/-45 g/day) were infused. The ratio insulin/body weight and insulin/carbohydrates were equal in both groups. In the GFX group nonseptic and septic patients needed less and more insulin, respectively, than their counterparts in the G group. No major adverse events related to carbohydrate infusions were observed. CONCLUSIONS: Either G or GFX could be used in TPN for diabetic patients, providing glycemic control in most cases with similar insulin requirements. GFX mixtures were slightly more beneficial to attain glycemic control in nonseptic patients, but septic diabetic patients had higher insulin needs in this group. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/11781679/Evaluation_of_nonglucose_carbohydrates_in_parenteral_nutrition_for_diabetic_patients_ L2 - https://doi.org/10.1038/sj.ejcn.1601274 DB - PRIME DP - Unbound Medicine ER -