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Prokinetics and reflux: a promise unfulfilled.
Eur J Gastroenterol Hepatol. 2002 Jan; 14(1):5-7.EJ

Abstract

Gastro-oesophageal reflux disease (GORD) has been described as a motility disorder of the upper gastrointestinal tract. Disturbances of lower oesophageal sphincter function, lower oesophageal body motility, oesophageal clearance and gastric emptying are well accepted. Cisapride improves most of these but its clinical benefits have been relatively modest. Some recent studies have indicated that the improvements achieved with cisapride may be less marked than originally thought. Furthermore, the agent has no effect on transient lower oesophageal sphincter relaxations, nor on other important factors influencing gastro-oesophageal junction competence, such as the external sphincter function of the diaphragmatic crus and mechanical influences such as lower oesophageal sphincter length exposed to intra-abdominal pressure changes. More potent, specific and predictable prokinetic agents would be welcome, but are unlikely to be effective as single agents across the range of GORD. There is certainly a need for such agents, including cisapride, as adjuncts to acid suppression in patients who fail to respond to the latter.

Authors+Show Affiliations

Department of Gastroenterology, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK. john.decaestecker@uhl-tr.nhs.uk

Pub Type(s)

Comment
Journal Article

Language

eng

PubMed ID

11782568

Citation

de Caestecker, John. "Prokinetics and Reflux: a Promise Unfulfilled." European Journal of Gastroenterology & Hepatology, vol. 14, no. 1, 2002, pp. 5-7.
de Caestecker J. Prokinetics and reflux: a promise unfulfilled. Eur J Gastroenterol Hepatol. 2002;14(1):5-7.
de Caestecker, J. (2002). Prokinetics and reflux: a promise unfulfilled. European Journal of Gastroenterology & Hepatology, 14(1), 5-7.
de Caestecker J. Prokinetics and Reflux: a Promise Unfulfilled. Eur J Gastroenterol Hepatol. 2002;14(1):5-7. PubMed PMID: 11782568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prokinetics and reflux: a promise unfulfilled. A1 - de Caestecker,John, PY - 2002/1/10/pubmed PY - 2002/2/13/medline PY - 2002/1/10/entrez SP - 5 EP - 7 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 14 IS - 1 N2 - Gastro-oesophageal reflux disease (GORD) has been described as a motility disorder of the upper gastrointestinal tract. Disturbances of lower oesophageal sphincter function, lower oesophageal body motility, oesophageal clearance and gastric emptying are well accepted. Cisapride improves most of these but its clinical benefits have been relatively modest. Some recent studies have indicated that the improvements achieved with cisapride may be less marked than originally thought. Furthermore, the agent has no effect on transient lower oesophageal sphincter relaxations, nor on other important factors influencing gastro-oesophageal junction competence, such as the external sphincter function of the diaphragmatic crus and mechanical influences such as lower oesophageal sphincter length exposed to intra-abdominal pressure changes. More potent, specific and predictable prokinetic agents would be welcome, but are unlikely to be effective as single agents across the range of GORD. There is certainly a need for such agents, including cisapride, as adjuncts to acid suppression in patients who fail to respond to the latter. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/11782568/Prokinetics_and_reflux:_a_promise_unfulfilled_ L2 - http://dx.doi.org/10.1097/00042737-200201000-00002 DB - PRIME DP - Unbound Medicine ER -