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The effect of cisapride on oesophageal motility and lower sphincter function in patients with gastro-oesophageal reflux disease.
Eur J Gastroenterol Hepatol 2002; 14(1):9-14EJ

Abstract

OBJECTIVES

To evaluate the efficiency by which the 5-HT4 agonist cisapride affects important motor functions involved in the control of gastro-oesophageal reflux.

METHOD

Thirty patients with proven gastro-oesophageal reflux disease (endoscopy and 24 h pH-metry) were included in a randomized, double-blind, placebo controlled study with a cross-over design. Cisapride, 20 mg b.i.d., during 4 weeks was compared with placebo. At baseline, as well as after 4 and 8 weeks all patients underwent symptom assessments, sleeve manometry with concomitant oesophageal pH-monitoring and an acid clearance test.

RESULTS

Despite adequate plasma levels cisapride had no significant effect on swallow induced peristaltic amplitude, duration, propagation speed, the elicitation of secondary peristalsis nor on acid clearance. Neither the basal tone of the lower oesophageal sphincter nor the number of transient lower oesophageal sphincter relaxations induced by gas distension of the stomach was affected by the administered dose of cisapride.

CONCLUSION

Although cisapride has been alleged to improve symptoms as well as the oesophagitis in patients with gastro-oesophageal reflux disease, we found the compound (20 mg b.i.d.) devoid of effects on important motor mechanisms involved in the pathogenesis of the disease.

Authors+Show Affiliations

Departments of Otorhinolaryngology and Surgery, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11782569

Citation

Finizia, Caterina, et al. "The Effect of Cisapride On Oesophageal Motility and Lower Sphincter Function in Patients With Gastro-oesophageal Reflux Disease." European Journal of Gastroenterology & Hepatology, vol. 14, no. 1, 2002, pp. 9-14.
Finizia C, Lundell L, Cange L, et al. The effect of cisapride on oesophageal motility and lower sphincter function in patients with gastro-oesophageal reflux disease. Eur J Gastroenterol Hepatol. 2002;14(1):9-14.
Finizia, C., Lundell, L., Cange, L., & Ruth, M. (2002). The effect of cisapride on oesophageal motility and lower sphincter function in patients with gastro-oesophageal reflux disease. European Journal of Gastroenterology & Hepatology, 14(1), pp. 9-14.
Finizia C, et al. The Effect of Cisapride On Oesophageal Motility and Lower Sphincter Function in Patients With Gastro-oesophageal Reflux Disease. Eur J Gastroenterol Hepatol. 2002;14(1):9-14. PubMed PMID: 11782569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of cisapride on oesophageal motility and lower sphincter function in patients with gastro-oesophageal reflux disease. AU - Finizia,Caterina, AU - Lundell,Lars, AU - Cange,Lars, AU - Ruth,Magnus, PY - 2002/1/10/pubmed PY - 2002/2/13/medline PY - 2002/1/10/entrez SP - 9 EP - 14 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 14 IS - 1 N2 - OBJECTIVES: To evaluate the efficiency by which the 5-HT4 agonist cisapride affects important motor functions involved in the control of gastro-oesophageal reflux. METHOD: Thirty patients with proven gastro-oesophageal reflux disease (endoscopy and 24 h pH-metry) were included in a randomized, double-blind, placebo controlled study with a cross-over design. Cisapride, 20 mg b.i.d., during 4 weeks was compared with placebo. At baseline, as well as after 4 and 8 weeks all patients underwent symptom assessments, sleeve manometry with concomitant oesophageal pH-monitoring and an acid clearance test. RESULTS: Despite adequate plasma levels cisapride had no significant effect on swallow induced peristaltic amplitude, duration, propagation speed, the elicitation of secondary peristalsis nor on acid clearance. Neither the basal tone of the lower oesophageal sphincter nor the number of transient lower oesophageal sphincter relaxations induced by gas distension of the stomach was affected by the administered dose of cisapride. CONCLUSION: Although cisapride has been alleged to improve symptoms as well as the oesophagitis in patients with gastro-oesophageal reflux disease, we found the compound (20 mg b.i.d.) devoid of effects on important motor mechanisms involved in the pathogenesis of the disease. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/11782569/The_effect_of_cisapride_on_oesophageal_motility_and_lower_sphincter_function_in_patients_with_gastro_oesophageal_reflux_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=11782569 DB - PRIME DP - Unbound Medicine ER -