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Relationship between plasma levels of cardiac natriuretic peptides and soluble Fas: plasma soluble Fas as a prognostic predictor in patients with congestive heart failure.
J Card Fail. 2001 Dec; 7(4):322-8.JC

Abstract

BACKGROUND

Cardiac natriuretic peptides may induce apoptosis in myocytes; however, the relationship between plasma levels of cardiac natriuretic peptides and those of soluble Fas (sFas) and tumor necrosis factor (TNF)-alpha remains unknown in patients with congestive heart failure (CHF).

METHODS AND RESULTS

We measured plasma levels of sFas and TNF-alpha and those of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), norepinephrine, and endothelin 1 in 96 patients with CHF (ejection fraction < 45%). The patients were monitored for 3 years. Plasma levels of sFas and TNF-alpha increased with the severity of CHF. There was no significant correlation between sFas plasma levels and those of ANP and BNP. Cox proportional hazard analysis showed that high levels of sFas (P = .009) and BNP (P < .0001) and a low ejection fraction (P = .019) were independent significant prognostic predictors.

CONCLUSIONS

There is no significant correlation between cardiac natriuretic peptide and sFas levels in plasma. Plasma sFas is a useful prognostic marker independent of neurohumoral factors, suggesting that immune activation and/or apoptosis play a significant role in the pathogenesis of CHF.

Authors+Show Affiliations

First Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11782855

Citation

Tsutamoto, T, et al. "Relationship Between Plasma Levels of Cardiac Natriuretic Peptides and Soluble Fas: Plasma Soluble Fas as a Prognostic Predictor in Patients With Congestive Heart Failure." Journal of Cardiac Failure, vol. 7, no. 4, 2001, pp. 322-8.
Tsutamoto T, Wada A, Maeda K, et al. Relationship between plasma levels of cardiac natriuretic peptides and soluble Fas: plasma soluble Fas as a prognostic predictor in patients with congestive heart failure. J Card Fail. 2001;7(4):322-8.
Tsutamoto, T., Wada, A., Maeda, K., Mabuchi, N., Hayashi, M., Tsutsui, T., Ohnishi, M., Fujii, M., Matsumoto, T., Yamamoto, T., Takayama, T., & Kinoshita, M. (2001). Relationship between plasma levels of cardiac natriuretic peptides and soluble Fas: plasma soluble Fas as a prognostic predictor in patients with congestive heart failure. Journal of Cardiac Failure, 7(4), 322-8.
Tsutamoto T, et al. Relationship Between Plasma Levels of Cardiac Natriuretic Peptides and Soluble Fas: Plasma Soluble Fas as a Prognostic Predictor in Patients With Congestive Heart Failure. J Card Fail. 2001;7(4):322-8. PubMed PMID: 11782855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between plasma levels of cardiac natriuretic peptides and soluble Fas: plasma soluble Fas as a prognostic predictor in patients with congestive heart failure. AU - Tsutamoto,T, AU - Wada,A, AU - Maeda,K, AU - Mabuchi,N, AU - Hayashi,M, AU - Tsutsui,T, AU - Ohnishi,M, AU - Fujii,M, AU - Matsumoto,T, AU - Yamamoto,T, AU - Takayama,T, AU - Kinoshita,M, PY - 2002/1/10/pubmed PY - 2002/2/8/medline PY - 2002/1/10/entrez SP - 322 EP - 8 JF - Journal of cardiac failure JO - J Card Fail VL - 7 IS - 4 N2 - BACKGROUND: Cardiac natriuretic peptides may induce apoptosis in myocytes; however, the relationship between plasma levels of cardiac natriuretic peptides and those of soluble Fas (sFas) and tumor necrosis factor (TNF)-alpha remains unknown in patients with congestive heart failure (CHF). METHODS AND RESULTS: We measured plasma levels of sFas and TNF-alpha and those of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), norepinephrine, and endothelin 1 in 96 patients with CHF (ejection fraction < 45%). The patients were monitored for 3 years. Plasma levels of sFas and TNF-alpha increased with the severity of CHF. There was no significant correlation between sFas plasma levels and those of ANP and BNP. Cox proportional hazard analysis showed that high levels of sFas (P = .009) and BNP (P < .0001) and a low ejection fraction (P = .019) were independent significant prognostic predictors. CONCLUSIONS: There is no significant correlation between cardiac natriuretic peptide and sFas levels in plasma. Plasma sFas is a useful prognostic marker independent of neurohumoral factors, suggesting that immune activation and/or apoptosis play a significant role in the pathogenesis of CHF. SN - 1071-9164 UR - https://www.unboundmedicine.com/medline/citation/11782855/Relationship_between_plasma_levels_of_cardiac_natriuretic_peptides_and_soluble_Fas:_plasma_soluble_Fas_as_a_prognostic_predictor_in_patients_with_congestive_heart_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1071-9164(01)91463-0 DB - PRIME DP - Unbound Medicine ER -