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[Effects of kidney nourishing and spleen invigorating recipes on glucocorticoid receptors of pulmonary tissue and plasma corticosterone in asthmatic rats].
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Aug; 19(8):487-9.ZZ

Abstract

OBJECTIVE

To observe the effects of Guiqi San (GQS, a Chinese herbal preparation with effect of Kidney Nourishing and Spleen Invigorating), Bushen Dingchuan Tang (BSDCT, with effects of Kidney Nourishing) and Liujunzi Tang (LJZT, with effect of Spleen Invigorating) on glucocorticoid receptor (GCR) and plasma corticosterone (PCC) in asthmatic rats.

METHODS

The asthmatic model of rats made by intraperitoneal injection of ovalbumin two weeks before, and the asthma consecutively challenged daily with spray inhalation of 1% ovalbumin for 7 days. The asthmatic rat treated with above-mentioned three recipes (per os) and Beclomethasone dipropionate (BDP) were taken as treated groups and the asthmatic rat as control group. GCR density of the pulmonary tissue and PCC were determined by radioligand-binding assay and competitive protein radio-binding assay.

RESULTS

The RT value of GCR reduced gradually and PCC lowered also after asthma being developed. On day 7th, the three recipes could markedly up-regulate the RT of GCR and PCC. There was significant difference statistically as compared the pulmonary tissue GCR density and PCC of GQS (P < 0.01, P < 0.05), BSDCT (P < 0.05, P < 0.05) and LJZT (P < 0.05, P < 0.05) groups with those of control (asthmatic group) on the 7th day.

CONCLUSION

GQS, BSDCT and LJZT played an up-regulate role of GCR density and improvement of adrenocortical function in asthmatic rats in the management of asthma attacks.

Authors+Show Affiliations

Department of TCM Basic Theory, Shanghai University of TCM, Shanghai, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11783231

Citation

Bao, Z, et al. "[Effects of Kidney Nourishing and Spleen Invigorating Recipes On Glucocorticoid Receptors of Pulmonary Tissue and Plasma Corticosterone in Asthmatic Rats]." Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, vol. 19, no. 8, 1999, pp. 487-9.
Bao Z, Wu D, Chen S. [Effects of kidney nourishing and spleen invigorating recipes on glucocorticoid receptors of pulmonary tissue and plasma corticosterone in asthmatic rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999;19(8):487-9.
Bao, Z., Wu, D., & Chen, S. (1999). [Effects of kidney nourishing and spleen invigorating recipes on glucocorticoid receptors of pulmonary tissue and plasma corticosterone in asthmatic rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, 19(8), 487-9.
Bao Z, Wu D, Chen S. [Effects of Kidney Nourishing and Spleen Invigorating Recipes On Glucocorticoid Receptors of Pulmonary Tissue and Plasma Corticosterone in Asthmatic Rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999;19(8):487-9. PubMed PMID: 11783231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of kidney nourishing and spleen invigorating recipes on glucocorticoid receptors of pulmonary tissue and plasma corticosterone in asthmatic rats]. AU - Bao,Z, AU - Wu,D, AU - Chen,S, PY - 2002/1/11/pubmed PY - 2002/4/27/medline PY - 2002/1/11/entrez SP - 487 EP - 9 JF - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine JO - Zhongguo Zhong Xi Yi Jie He Za Zhi VL - 19 IS - 8 N2 - OBJECTIVE: To observe the effects of Guiqi San (GQS, a Chinese herbal preparation with effect of Kidney Nourishing and Spleen Invigorating), Bushen Dingchuan Tang (BSDCT, with effects of Kidney Nourishing) and Liujunzi Tang (LJZT, with effect of Spleen Invigorating) on glucocorticoid receptor (GCR) and plasma corticosterone (PCC) in asthmatic rats. METHODS: The asthmatic model of rats made by intraperitoneal injection of ovalbumin two weeks before, and the asthma consecutively challenged daily with spray inhalation of 1% ovalbumin for 7 days. The asthmatic rat treated with above-mentioned three recipes (per os) and Beclomethasone dipropionate (BDP) were taken as treated groups and the asthmatic rat as control group. GCR density of the pulmonary tissue and PCC were determined by radioligand-binding assay and competitive protein radio-binding assay. RESULTS: The RT value of GCR reduced gradually and PCC lowered also after asthma being developed. On day 7th, the three recipes could markedly up-regulate the RT of GCR and PCC. There was significant difference statistically as compared the pulmonary tissue GCR density and PCC of GQS (P < 0.01, P < 0.05), BSDCT (P < 0.05, P < 0.05) and LJZT (P < 0.05, P < 0.05) groups with those of control (asthmatic group) on the 7th day. CONCLUSION: GQS, BSDCT and LJZT played an up-regulate role of GCR density and improvement of adrenocortical function in asthmatic rats in the management of asthma attacks. SN - 1003-5370 UR - https://www.unboundmedicine.com/medline/citation/11783231/[Effects_of_kidney_nourishing_and_spleen_invigorating_recipes_on_glucocorticoid_receptors_of_pulmonary_tissue_and_plasma_corticosterone_in_asthmatic_rats]_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -