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Influence of chronic treatment with H1 receptor antagonists on the anticonvulsant activity of antiepileptic drugs.
Pol J Pharmacol. 2001 Jan-Feb; 53(1):93-6.PJ

Abstract

The aim of this study was to evaluate the effects of chronic astemizole and ketotifen administration on the anticonvulsant activity of antiepileptic drugs against maximal electroshock-induced convulsions in mice. Adverse effects were evaluated in the chimney test (motor performance) and passive avoidance task (long-term memory). Brain and plasma levels of antiepileptics were measured by immunofluorescence. Astemizole (2 mg/kg) and ketotifen (8 mg/kg) significantly diminished the electroconvulsive threshold, being without effect upon this parameter at lower doses. Astemizole significantly reduced the anticonvulsant action of phenobarbital and diphenylhydantoin, but it did not affect that of carbamazepine and valproate. Moreover, ketotifen (at the subprotective dose of 4 mg/kg) remained without effect upon the protective activity of valproate, diphenylhydantoin or phenobarbital, but significantly diminished the anticonvulsant effect of carbamazepine. Histamine receptor antagonists combined with antiepileptic drugs, did not alter their brain and free plasma levels. Also, they did not influence adverse potential of carbamazepine, diphenylhydantoin and valproate while that of phenobarbital was significantly enhanced. Valproate, phenobarbital and diphenylhydantoin alone at their ED50s against maximal electroshock or combined with the histamine receptor antagonists disturbed long-term memory. The results of this study indicate that H1 receptor antagonists, should be used with caution in epileptic patients.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Medical University, Lublin, Poland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11785920

Citation

Swiader, M, et al. "Influence of Chronic Treatment With H1 Receptor Antagonists On the Anticonvulsant Activity of Antiepileptic Drugs." Polish Journal of Pharmacology, vol. 53, no. 1, 2001, pp. 93-6.
Swiader M, Chwalczuk K, Wielosz M, et al. Influence of chronic treatment with H1 receptor antagonists on the anticonvulsant activity of antiepileptic drugs. Pol J Pharmacol. 2001;53(1):93-6.
Swiader, M., Chwalczuk, K., Wielosz, M., & Czuczwar, S. J. (2001). Influence of chronic treatment with H1 receptor antagonists on the anticonvulsant activity of antiepileptic drugs. Polish Journal of Pharmacology, 53(1), 93-6.
Swiader M, et al. Influence of Chronic Treatment With H1 Receptor Antagonists On the Anticonvulsant Activity of Antiepileptic Drugs. Pol J Pharmacol. 2001 Jan-Feb;53(1):93-6. PubMed PMID: 11785920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of chronic treatment with H1 receptor antagonists on the anticonvulsant activity of antiepileptic drugs. AU - Swiader,M, AU - Chwalczuk,K, AU - Wielosz,M, AU - Czuczwar,S J, PY - 2002/1/12/pubmed PY - 2002/6/14/medline PY - 2002/1/12/entrez SP - 93 EP - 6 JF - Polish journal of pharmacology JO - Pol J Pharmacol VL - 53 IS - 1 N2 - The aim of this study was to evaluate the effects of chronic astemizole and ketotifen administration on the anticonvulsant activity of antiepileptic drugs against maximal electroshock-induced convulsions in mice. Adverse effects were evaluated in the chimney test (motor performance) and passive avoidance task (long-term memory). Brain and plasma levels of antiepileptics were measured by immunofluorescence. Astemizole (2 mg/kg) and ketotifen (8 mg/kg) significantly diminished the electroconvulsive threshold, being without effect upon this parameter at lower doses. Astemizole significantly reduced the anticonvulsant action of phenobarbital and diphenylhydantoin, but it did not affect that of carbamazepine and valproate. Moreover, ketotifen (at the subprotective dose of 4 mg/kg) remained without effect upon the protective activity of valproate, diphenylhydantoin or phenobarbital, but significantly diminished the anticonvulsant effect of carbamazepine. Histamine receptor antagonists combined with antiepileptic drugs, did not alter their brain and free plasma levels. Also, they did not influence adverse potential of carbamazepine, diphenylhydantoin and valproate while that of phenobarbital was significantly enhanced. Valproate, phenobarbital and diphenylhydantoin alone at their ED50s against maximal electroshock or combined with the histamine receptor antagonists disturbed long-term memory. The results of this study indicate that H1 receptor antagonists, should be used with caution in epileptic patients. SN - 1230-6002 UR - https://www.unboundmedicine.com/medline/citation/11785920/Influence_of_chronic_treatment_with_H1_receptor_antagonists_on_the_anticonvulsant_activity_of_antiepileptic_drugs_ L2 - http://www.if-pan.krakow.pl/pjp/pdf/2001/1_93.pdf DB - PRIME DP - Unbound Medicine ER -