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Wernicke's encephalopathy due to hyperemesis gravidarum: an under-recognised condition.
Aust N Z J Obstet Gynaecol. 2001 Nov; 41(4):453-6.AN

Abstract

We present a case of a 25-year-old woman with drowsiness, nystagmus, severe ataxia and areflexia, which developed six weeks after admission to an obstetric clinic for hyperemesis gravidarum. She had been treated with intravenous dextrose and electrolyte solutions and antiemetics. Magnetic resonance imaging (MRI) performed on the fifth day of her neurologic symptoms showed increased intensity in both thalami, periaqueductal grey matter, the floor of the fourth ventricle and superior cerebellar vermis in T2 weighted and FLAIR images. Clinical signs and MRI findings were consistent with the diagnosis of Wernicke's encephalopathy. On the third day of thiamine replacement, neurologic signs improved dramatically In addition to our case, we review 29 previously reported cases of Wernicke's encephalopathy associated with hyperemesis gravidarum, and emphasize the importance of thiamine supplementation to women with prolonged vomiting in pregnancy especially if they are given intravenous or parenteral nutrition.

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Authors+Show Affiliations

Togay-Işikay C
Department of Neurology, Faculty of Medicine, University of Ankara, Turkey.
Yiğit A
No affiliation info available
Mutluer N
No affiliation info available

MeSH

AdultAtaxiaDiagnosis, DifferentialFemaleHumansHyperemesis GravidarumInfant, NewbornInjections, IntramuscularMagnetic Resonance ImagingPregnancyThiamineWernicke Encephalopathy

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

11787926

Citation

Togay-Işikay, C, et al. "Wernicke's Encephalopathy Due to Hyperemesis Gravidarum: an Under-recognised Condition." The Australian & New Zealand Journal of Obstetrics & Gynaecology, vol. 41, no. 4, 2001, pp. 453-6.
Togay-Işikay C, Yiğit A, Mutluer N. Wernicke's encephalopathy due to hyperemesis gravidarum: an under-recognised condition. Aust N Z J Obstet Gynaecol. 2001;41(4):453-6.
Togay-Işikay, C., Yiğit, A., & Mutluer, N. (2001). Wernicke's encephalopathy due to hyperemesis gravidarum: an under-recognised condition. The Australian & New Zealand Journal of Obstetrics & Gynaecology, 41(4), 453-6.
Togay-Işikay C, Yiğit A, Mutluer N. Wernicke's Encephalopathy Due to Hyperemesis Gravidarum: an Under-recognised Condition. Aust N Z J Obstet Gynaecol. 2001;41(4):453-6. PubMed PMID: 11787926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wernicke's encephalopathy due to hyperemesis gravidarum: an under-recognised condition. AU - Togay-Işikay,C, AU - Yiğit,A, AU - Mutluer,N, PY - 2002/1/15/pubmed PY - 2002/6/14/medline PY - 2002/1/15/entrez SP - 453 EP - 6 JF - The Australian & New Zealand journal of obstetrics & gynaecology JO - Aust N Z J Obstet Gynaecol VL - 41 IS - 4 N2 - We present a case of a 25-year-old woman with drowsiness, nystagmus, severe ataxia and areflexia, which developed six weeks after admission to an obstetric clinic for hyperemesis gravidarum. She had been treated with intravenous dextrose and electrolyte solutions and antiemetics. Magnetic resonance imaging (MRI) performed on the fifth day of her neurologic symptoms showed increased intensity in both thalami, periaqueductal grey matter, the floor of the fourth ventricle and superior cerebellar vermis in T2 weighted and FLAIR images. Clinical signs and MRI findings were consistent with the diagnosis of Wernicke's encephalopathy. On the third day of thiamine replacement, neurologic signs improved dramatically In addition to our case, we review 29 previously reported cases of Wernicke's encephalopathy associated with hyperemesis gravidarum, and emphasize the importance of thiamine supplementation to women with prolonged vomiting in pregnancy especially if they are given intravenous or parenteral nutrition. SN - 0004-8666 UR - https://www.unboundmedicine.com/medline/citation/11787926/Wernicke's_encephalopathy_due_to_hyperemesis_gravidarum:_an_under_recognised_condition_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0004-8666&date=2001&volume=41&issue=4&spage=453 DB - PRIME DP - Unbound Medicine ER -