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Selenium, glutathione peroxidases, and some other antioxidant parameters in blood of patients with chronic renal failure.
J Trace Elem Med Biol. 2001; 15(2-3):161-6.JT

Abstract

In the present study several parameters associated with oxidative stress were examined in the blood of 25 chronic renal failure (CRF) patients and the results were compared with 18 healthy subjects. Mean creatinine concentration in patients was 1,216 +/- 292 micromol/l. Selenium (Se) concentration in red cells, whole blood and in plasma of CRF patients (106 +/- 32.5, 59.0 +/- 16.7 and 42.4 +/- 13.8 ng/ml, respectively) was significantly (0.0001 < P 0.01) lower (by 20-42%) compared with the controls. Red cell and plasma glutathione peroxidase (GSH-Px) activities (16.6 +/- 3.4 U/g Hb and 93.7 +/- 32.9 U/l plasma) were lower by 12 and 53% (P < 0.05 and < 0.0001, respectively) in patients than in healthy subjects. GSH concentration in red cells of patients (2.81 +/- 0.45 mmol/l) was significantly (P < 0.001) higher (by 20%) than in control group. Malonyldialdehyde (MDA) concentration (expressed as thiobarbituric acid-reactive substances) in red cells of patients (725 +/- 155 nmol/g Hb) was significantly (P < 0.001) higher (by 28%) than in control group. No significant difference was observed in the activity of superoxide dismutase in pLasma between the two groups. In conclusion, our results confirm that the aLterations in Se levels in blood components and in GSH-Px activity in plasma show that the kidney plays an important role in Se homeostasis and in plasma GSH-Px synthesis.

Authors+Show Affiliations

Department of Biochemistry, The Ludwik Rydygier Medical University, Bydgoszcz, Poland. Bronz@ACI.AMB.Bydgoszcz.PlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11787983

Citation

Zachara, B A., et al. "Selenium, Glutathione Peroxidases, and some Other Antioxidant Parameters in Blood of Patients With Chronic Renal Failure." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 15, no. 2-3, 2001, pp. 161-6.
Zachara BA, Trafikowska U, Adamowicz A, et al. Selenium, glutathione peroxidases, and some other antioxidant parameters in blood of patients with chronic renal failure. J Trace Elem Med Biol. 2001;15(2-3):161-6.
Zachara, B. A., Trafikowska, U., Adamowicz, A., Nartowicz, E., & Manitius, J. (2001). Selenium, glutathione peroxidases, and some other antioxidant parameters in blood of patients with chronic renal failure. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 15(2-3), 161-6.
Zachara BA, et al. Selenium, Glutathione Peroxidases, and some Other Antioxidant Parameters in Blood of Patients With Chronic Renal Failure. J Trace Elem Med Biol. 2001;15(2-3):161-6. PubMed PMID: 11787983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium, glutathione peroxidases, and some other antioxidant parameters in blood of patients with chronic renal failure. AU - Zachara,B A, AU - Trafikowska,U, AU - Adamowicz,A, AU - Nartowicz,E, AU - Manitius,J, PY - 2002/1/15/pubmed PY - 2002/6/27/medline PY - 2002/1/15/entrez SP - 161 EP - 6 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 15 IS - 2-3 N2 - In the present study several parameters associated with oxidative stress were examined in the blood of 25 chronic renal failure (CRF) patients and the results were compared with 18 healthy subjects. Mean creatinine concentration in patients was 1,216 +/- 292 micromol/l. Selenium (Se) concentration in red cells, whole blood and in plasma of CRF patients (106 +/- 32.5, 59.0 +/- 16.7 and 42.4 +/- 13.8 ng/ml, respectively) was significantly (0.0001 < P 0.01) lower (by 20-42%) compared with the controls. Red cell and plasma glutathione peroxidase (GSH-Px) activities (16.6 +/- 3.4 U/g Hb and 93.7 +/- 32.9 U/l plasma) were lower by 12 and 53% (P < 0.05 and < 0.0001, respectively) in patients than in healthy subjects. GSH concentration in red cells of patients (2.81 +/- 0.45 mmol/l) was significantly (P < 0.001) higher (by 20%) than in control group. Malonyldialdehyde (MDA) concentration (expressed as thiobarbituric acid-reactive substances) in red cells of patients (725 +/- 155 nmol/g Hb) was significantly (P < 0.001) higher (by 28%) than in control group. No significant difference was observed in the activity of superoxide dismutase in pLasma between the two groups. In conclusion, our results confirm that the aLterations in Se levels in blood components and in GSH-Px activity in plasma show that the kidney plays an important role in Se homeostasis and in plasma GSH-Px synthesis. SN - 0946-672X UR - https://www.unboundmedicine.com/medline/citation/11787983/Selenium_glutathione_peroxidases_and_some_other_antioxidant_parameters_in_blood_of_patients_with_chronic_renal_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0946-672X(01)80061-4 DB - PRIME DP - Unbound Medicine ER -