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[Current approaches in prevention and therapy of chemo- and radiotherapy-induced oral mucositis].
Wien Med Wochenschr 2001; 151(3-4):53-65WM

Abstract

Oral mucositis is a major, often dose-limiting toxicity in modern cancer-therapy, leading to dose reductions or delay in further cancer treatment. It predisposes to life-threatening septic complication during aplasia and substantially reduces quality of life for cancer patients. At present the basic strategies in oral mucositis aim at pain relief and prevention of infectious complications. However, no effective causal prophylaxis or treatment of oral mucositis is widely accepted. The introduction of cytokines, e.g. granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF), the use of cytoprotective agents, e.g. amifostine and the stimulation of basal-cell proliferation by soft-laser irradiation or silver nitrate offer new and hopeful approaches in oral mucositis. Large-scale clinical trials to confirm effectiveness and optimize treatment schedules have to be done.

Authors+Show Affiliations

Abteilung für Hämatologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstrasse 55, D-45144 Essen, Deutschland. thm050@uni-essen.deNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

11789420

Citation

Rosenthal, C, and M Karthaus. "[Current Approaches in Prevention and Therapy of Chemo- and Radiotherapy-induced Oral Mucositis]." Wiener Medizinische Wochenschrift (1946), vol. 151, no. 3-4, 2001, pp. 53-65.
Rosenthal C, Karthaus M. [Current approaches in prevention and therapy of chemo- and radiotherapy-induced oral mucositis]. Wien Med Wochenschr. 2001;151(3-4):53-65.
Rosenthal, C., & Karthaus, M. (2001). [Current approaches in prevention and therapy of chemo- and radiotherapy-induced oral mucositis]. Wiener Medizinische Wochenschrift (1946), 151(3-4), pp. 53-65.
Rosenthal C, Karthaus M. [Current Approaches in Prevention and Therapy of Chemo- and Radiotherapy-induced Oral Mucositis]. Wien Med Wochenschr. 2001;151(3-4):53-65. PubMed PMID: 11789420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Current approaches in prevention and therapy of chemo- and radiotherapy-induced oral mucositis]. AU - Rosenthal,C, AU - Karthaus,M, PY - 2002/1/16/pubmed PY - 2002/2/23/medline PY - 2002/1/16/entrez SP - 53 EP - 65 JF - Wiener medizinische Wochenschrift (1946) JO - Wien Med Wochenschr VL - 151 IS - 3-4 N2 - Oral mucositis is a major, often dose-limiting toxicity in modern cancer-therapy, leading to dose reductions or delay in further cancer treatment. It predisposes to life-threatening septic complication during aplasia and substantially reduces quality of life for cancer patients. At present the basic strategies in oral mucositis aim at pain relief and prevention of infectious complications. However, no effective causal prophylaxis or treatment of oral mucositis is widely accepted. The introduction of cytokines, e.g. granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF), the use of cytoprotective agents, e.g. amifostine and the stimulation of basal-cell proliferation by soft-laser irradiation or silver nitrate offer new and hopeful approaches in oral mucositis. Large-scale clinical trials to confirm effectiveness and optimize treatment schedules have to be done. SN - 0043-5341 UR - https://www.unboundmedicine.com/medline/citation/11789420/[Current_approaches_in_prevention_and_therapy_of_chemo__and_radiotherapy_induced_oral_mucositis]_ L2 - https://medlineplus.gov/cancerchemotherapy.html DB - PRIME DP - Unbound Medicine ER -