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Carotid plaques, but not common carotid intima-media thickness, are independently associated with aortic stiffness.
J Hypertens 2002; 20(1):85-93JH

Abstract

OBJECTIVE

It has been suggested that non-invasive aortic stiffness measurements can be used as an indicator of atherosclerosis. The relationships of arterial stiffness with arterial wall hypertrophy and atherosclerosis however, have rarely been investigated in large-scale studies. The present study reports the associations of carotid arterial structure assessed by B-mode ultrasound with carotid-femoral pulse-wave velocity in hypertensive and non-hypertensive subjects.

DESIGN AND METHODS

Free health examinations were performed on 564 subjects (age 58.2 +/- 10.8 years, 31.9% of women, 53.2% of all were hypertensive). Carotid-femoral pulse-wave velocity (PWV) was used to assess aortic stiffness. Carotid ultrasound examination included measurements (at sites free of plaques) of intima-media thickness (IMT) at the common carotid arteries (CCA), CCA-lumen diameter, and assessment of atherosclerotic plaques in the extracranial carotid arteries.

RESULTS

Subjects with carotid plaques had significantly higher mean sex-adjusted values of PWV than those without carotid plaques (12.7 +/- 0.2 versus 11.1 +/- 0.1 m/s, P < 0.001). Multivariate analyses showed that this association was independent of sex, age, height, body mass index, mean blood pressure, pulse pressure, diabetes, hypercholesterolaemia and smoking habits (P < 0.009). PWV was positively associated with CCA-IMT and CCA-lumen diameter in sex-adjusted analysis (partial correlation coefficients (r) were respectively 0.39 and 0.42, P < 0.001 for each). However, the association of PWV with CCA-IMT, but not that with CCA-lumen diameter, disappeared after further adjustment for age and blood pressure measurements (mean blood pressure and/or pulse pressure).

CONCLUSION

This study shows that there is a differential association of PWV with CCA-IMT and carotid plaques. The nature of the independent positive association between atherosclerosis and arterial stiffness should be thoroughly investigated.

Authors+Show Affiliations

National Institute of Health and Medical Research (INSERM), Unit 258, Hôpital Paul Brousse, 16 av. Paul Vaillant Couturier, 94807 Villejuif Cedex, France. zureik@vjf.inserm.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11791030

Citation

Zureik, Mahmoud, et al. "Carotid Plaques, but Not Common Carotid Intima-media Thickness, Are Independently Associated With Aortic Stiffness." Journal of Hypertension, vol. 20, no. 1, 2002, pp. 85-93.
Zureik M, Temmar M, Adamopoulos C, et al. Carotid plaques, but not common carotid intima-media thickness, are independently associated with aortic stiffness. J Hypertens. 2002;20(1):85-93.
Zureik, M., Temmar, M., Adamopoulos, C., Bureau, J. M., Courbon, D., Thomas, F., ... Benetos, A. (2002). Carotid plaques, but not common carotid intima-media thickness, are independently associated with aortic stiffness. Journal of Hypertension, 20(1), pp. 85-93.
Zureik M, et al. Carotid Plaques, but Not Common Carotid Intima-media Thickness, Are Independently Associated With Aortic Stiffness. J Hypertens. 2002;20(1):85-93. PubMed PMID: 11791030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotid plaques, but not common carotid intima-media thickness, are independently associated with aortic stiffness. AU - Zureik,Mahmoud, AU - Temmar,Mohammed, AU - Adamopoulos,Chris, AU - Bureau,Jeanne-Marie, AU - Courbon,Dominique, AU - Thomas,Frédérique, AU - Bean,Kathryn, AU - Touboul,Pierre-Jean, AU - Ducimetière,Pierre, AU - Benetos,Athanase, PY - 2002/1/16/pubmed PY - 2002/4/11/medline PY - 2002/1/16/entrez SP - 85 EP - 93 JF - Journal of hypertension JO - J. Hypertens. VL - 20 IS - 1 N2 - OBJECTIVE: It has been suggested that non-invasive aortic stiffness measurements can be used as an indicator of atherosclerosis. The relationships of arterial stiffness with arterial wall hypertrophy and atherosclerosis however, have rarely been investigated in large-scale studies. The present study reports the associations of carotid arterial structure assessed by B-mode ultrasound with carotid-femoral pulse-wave velocity in hypertensive and non-hypertensive subjects. DESIGN AND METHODS: Free health examinations were performed on 564 subjects (age 58.2 +/- 10.8 years, 31.9% of women, 53.2% of all were hypertensive). Carotid-femoral pulse-wave velocity (PWV) was used to assess aortic stiffness. Carotid ultrasound examination included measurements (at sites free of plaques) of intima-media thickness (IMT) at the common carotid arteries (CCA), CCA-lumen diameter, and assessment of atherosclerotic plaques in the extracranial carotid arteries. RESULTS: Subjects with carotid plaques had significantly higher mean sex-adjusted values of PWV than those without carotid plaques (12.7 +/- 0.2 versus 11.1 +/- 0.1 m/s, P < 0.001). Multivariate analyses showed that this association was independent of sex, age, height, body mass index, mean blood pressure, pulse pressure, diabetes, hypercholesterolaemia and smoking habits (P < 0.009). PWV was positively associated with CCA-IMT and CCA-lumen diameter in sex-adjusted analysis (partial correlation coefficients (r) were respectively 0.39 and 0.42, P < 0.001 for each). However, the association of PWV with CCA-IMT, but not that with CCA-lumen diameter, disappeared after further adjustment for age and blood pressure measurements (mean blood pressure and/or pulse pressure). CONCLUSION: This study shows that there is a differential association of PWV with CCA-IMT and carotid plaques. The nature of the independent positive association between atherosclerosis and arterial stiffness should be thoroughly investigated. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/11791030/Carotid_plaques_but_not_common_carotid_intima_media_thickness_are_independently_associated_with_aortic_stiffness_ L2 - http://Insights.ovid.com/pubmed?pmid=11791030 DB - PRIME DP - Unbound Medicine ER -