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Guided shear horizontal surface acoustic wave sensors for chemical and biochemical detection in liquids.
Anal Chem. 2001 Dec 15; 73(24):5937-44.AC

Abstract

The design and performance of guided shear horizontal surface acoustic wave (guided SH-SAW) devices on LiTaO3 substrates are investigated for high-sensitivity chemical and biochemical sensors in liquids. Despite their structural similarity to Rayleigh SAW, SH-SAWs often propagate slightly deeper within the substrate, hence preventing the implementation of high-sensitivity detectors. The device sensitivity to mass and viscoelastic loading is increased using a thin guiding layer on the device surface. Because of their relatively low shear wave velocity, various polymers including poly(methyl methacrylate) (PMMA) and cyanoethyl cellulose (cured or cross-linked) are investigated as the guiding layers to trap the acoustic energy near the sensing surface. The devices have been tested in biosensing and chemical sensing experiments. Suitable design principles for these applications are discussed with regard to wave guidance, electrical passivation of the interdigital transducers from the liquid environments, acoustic loss, and sensor signal distortion. In biosensing experiments, using near-optimal PMMA thickness of approximately 2 microm, mass sensitivity greater than 1500 Hz/(ng/mm2) is demonstrated, resulting in a minimum detection limit less than 20 pg/mm2. For chemical sensor experiments, it is found that optimal waveguide thickness must be modified to account for the chemically sensitive layer which also acts to guide the SH-SAW. A detection limit of 780 (3 x peak-to-peak noise) or 180 ppb (3 x rms noise) is estimated from the present measurements for some organic compounds in water.

Authors+Show Affiliations

Josse F
Department of Electrical and Computer Engineering, Marquette University, Milwaukee, Wisconsin 53201-1881, USA.
Bender F
No affiliation info available
Cernose RW
No affiliation info available

MeSH

AcousticsAlgorithmsBiochemistryBiosensing TechniquesChemistry Techniques, AnalyticalImmunoglobulin GIndicators and ReagentsPolymersReproducibility of ResultsSerum Albumin, Bovine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

11791563

Citation

Josse, F, et al. "Guided Shear Horizontal Surface Acoustic Wave Sensors for Chemical and Biochemical Detection in Liquids." Analytical Chemistry, vol. 73, no. 24, 2001, pp. 5937-44.
Josse F, Bender F, Cernose RW. Guided shear horizontal surface acoustic wave sensors for chemical and biochemical detection in liquids. Anal Chem. 2001;73(24):5937-44.
Josse, F., Bender, F., & Cernose, R. W. (2001). Guided shear horizontal surface acoustic wave sensors for chemical and biochemical detection in liquids. Analytical Chemistry, 73(24), 5937-44.
Josse F, Bender F, Cernose RW. Guided Shear Horizontal Surface Acoustic Wave Sensors for Chemical and Biochemical Detection in Liquids. Anal Chem. 2001 Dec 15;73(24):5937-44. PubMed PMID: 11791563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Guided shear horizontal surface acoustic wave sensors for chemical and biochemical detection in liquids. AU - Josse,F, AU - Bender,F, AU - Cernose,R W, PY - 2002/1/17/pubmed PY - 2002/2/20/medline PY - 2002/1/17/entrez SP - 5937 EP - 44 JF - Analytical chemistry JO - Anal Chem VL - 73 IS - 24 N2 - The design and performance of guided shear horizontal surface acoustic wave (guided SH-SAW) devices on LiTaO3 substrates are investigated for high-sensitivity chemical and biochemical sensors in liquids. Despite their structural similarity to Rayleigh SAW, SH-SAWs often propagate slightly deeper within the substrate, hence preventing the implementation of high-sensitivity detectors. The device sensitivity to mass and viscoelastic loading is increased using a thin guiding layer on the device surface. Because of their relatively low shear wave velocity, various polymers including poly(methyl methacrylate) (PMMA) and cyanoethyl cellulose (cured or cross-linked) are investigated as the guiding layers to trap the acoustic energy near the sensing surface. The devices have been tested in biosensing and chemical sensing experiments. Suitable design principles for these applications are discussed with regard to wave guidance, electrical passivation of the interdigital transducers from the liquid environments, acoustic loss, and sensor signal distortion. In biosensing experiments, using near-optimal PMMA thickness of approximately 2 microm, mass sensitivity greater than 1500 Hz/(ng/mm2) is demonstrated, resulting in a minimum detection limit less than 20 pg/mm2. For chemical sensor experiments, it is found that optimal waveguide thickness must be modified to account for the chemically sensitive layer which also acts to guide the SH-SAW. A detection limit of 780 (3 x peak-to-peak noise) or 180 ppb (3 x rms noise) is estimated from the present measurements for some organic compounds in water. SN - 0003-2700 UR - https://www.unboundmedicine.com/medline/citation/11791563/Guided_shear_horizontal_surface_acoustic_wave_sensors_for_chemical_and_biochemical_detection_in_liquids_ L2 - https://doi.org/10.1021/ac010859e DB - PRIME DP - Unbound Medicine ER -