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Quantitative ultrastructural analysis of glycine- and gamma-aminobutyric acid-immunoreactive terminals on trigeminal alpha- and gamma-motoneuron somata in the rat.
J Comp Neurol. 2002 Jan 21; 442(4):308-19.JC

Abstract

Detailed knowledge of the inhibitory input to trigeminal motoneurons is needed to understand better the central mechanisms of jaw movements. Here a quantitative analysis of terminals contacting somata of jaw-closing (JC) and jaw-opening (JO) alpha-motoneurons, and of JC gamma-motoneurons, was performed by use of serial sectioning and postembedding immunogold cytochemistry. For each type of motoneuron, the synaptic boutons were classified into four groups, i.e., immunonegative boutons or boutons immunoreactive to glycine only, to gamma-aminobutyric acid (GABA) only, or to both glycine and GABA. The density of immunolabeled boutons was much higher for the alpha- than for the gamma-motoneurons. In the alpha-motoneuron populations, the immunolabeled boutons were subdivided into one large group of boutons containing glycine-like immunoreactivity only, one group of intermediate size harboring both glycine- and GABA-like immunoreactivity, and a small group of boutons containing GABA-like immunoreactivity only. The percentage of immunolabeled boutons was higher for JC than JO alpha-motoneurons, the most pronounced difference being observed for glycine-like immunoreactivity. In contrast, on the somatic membrane of gamma-motoneurons, the three types of immunoreactive bouton occurred at similar frequencies. These results indicate that trigeminal motoneurons are strongly and differentially controlled by premotoneurons containing glycine and/or GABA and suggest that these neurons play an important role for the generation of masticatory patterns.

Authors+Show Affiliations

Department of Oral Anatomy, School of Dentistry, Kyungpook University, Taegu 700-422, Korea. ycbae@knu.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11793336

Citation

Bae, Yong Chul, et al. "Quantitative Ultrastructural Analysis of Glycine- and Gamma-aminobutyric Acid-immunoreactive Terminals On Trigeminal Alpha- and Gamma-motoneuron Somata in the Rat." The Journal of Comparative Neurology, vol. 442, no. 4, 2002, pp. 308-19.
Bae YC, Choi BJ, Lee MG, et al. Quantitative ultrastructural analysis of glycine- and gamma-aminobutyric acid-immunoreactive terminals on trigeminal alpha- and gamma-motoneuron somata in the rat. J Comp Neurol. 2002;442(4):308-19.
Bae, Y. C., Choi, B. J., Lee, M. G., Lee, H. J., Park, K. P., Zhang, L. F., Honma, S., Fukami, H., Yoshida, A., Ottersen, O. P., & Shigenaga, Y. (2002). Quantitative ultrastructural analysis of glycine- and gamma-aminobutyric acid-immunoreactive terminals on trigeminal alpha- and gamma-motoneuron somata in the rat. The Journal of Comparative Neurology, 442(4), 308-19.
Bae YC, et al. Quantitative Ultrastructural Analysis of Glycine- and Gamma-aminobutyric Acid-immunoreactive Terminals On Trigeminal Alpha- and Gamma-motoneuron Somata in the Rat. J Comp Neurol. 2002 Jan 21;442(4):308-19. PubMed PMID: 11793336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative ultrastructural analysis of glycine- and gamma-aminobutyric acid-immunoreactive terminals on trigeminal alpha- and gamma-motoneuron somata in the rat. AU - Bae,Yong Chul, AU - Choi,Byung Ju, AU - Lee,Maan Gee, AU - Lee,Hyo Jeong, AU - Park,Kuk Pil, AU - Zhang,Li Fen, AU - Honma,Shiho, AU - Fukami,Hideyuki, AU - Yoshida,Atsushi, AU - Ottersen,Ole Petter, AU - Shigenaga,Yoshio, PY - 2002/1/17/pubmed PY - 2002/2/22/medline PY - 2002/1/17/entrez SP - 308 EP - 19 JF - The Journal of comparative neurology JO - J. Comp. Neurol. VL - 442 IS - 4 N2 - Detailed knowledge of the inhibitory input to trigeminal motoneurons is needed to understand better the central mechanisms of jaw movements. Here a quantitative analysis of terminals contacting somata of jaw-closing (JC) and jaw-opening (JO) alpha-motoneurons, and of JC gamma-motoneurons, was performed by use of serial sectioning and postembedding immunogold cytochemistry. For each type of motoneuron, the synaptic boutons were classified into four groups, i.e., immunonegative boutons or boutons immunoreactive to glycine only, to gamma-aminobutyric acid (GABA) only, or to both glycine and GABA. The density of immunolabeled boutons was much higher for the alpha- than for the gamma-motoneurons. In the alpha-motoneuron populations, the immunolabeled boutons were subdivided into one large group of boutons containing glycine-like immunoreactivity only, one group of intermediate size harboring both glycine- and GABA-like immunoreactivity, and a small group of boutons containing GABA-like immunoreactivity only. The percentage of immunolabeled boutons was higher for JC than JO alpha-motoneurons, the most pronounced difference being observed for glycine-like immunoreactivity. In contrast, on the somatic membrane of gamma-motoneurons, the three types of immunoreactive bouton occurred at similar frequencies. These results indicate that trigeminal motoneurons are strongly and differentially controlled by premotoneurons containing glycine and/or GABA and suggest that these neurons play an important role for the generation of masticatory patterns. SN - 0021-9967 UR - https://www.unboundmedicine.com/medline/citation/11793336/Quantitative_ultrastructural_analysis_of_glycine__and_gamma_aminobutyric_acid_immunoreactive_terminals_on_trigeminal_alpha__and_gamma_motoneuron_somata_in_the_rat_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0021-9967&date=2002&volume=442&issue=4&spage=308 DB - PRIME DP - Unbound Medicine ER -