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Effect of norethindrone acetate on hormone levels and markers of bone turnover in estrogen-treated postmenopausal women.
Endocr Res. 2001 Nov; 27(4):473-80.ER

Abstract

There is controversy concerning the effects of progestins on bone. Norethindrone acetate (NETA) is synthetic progesterone that also has estrogenic and androgenic effects. We tested its effects on hormone levels, lipids and biochemical markers of bone turnover in postmenopausal women who were on estrogen replacement therapy. Women were treated with NETA, 5 mg/d for 9 weeks. Estrogenic effects included a marked lowering of follicle stimulating hormone and luteinizing hormone. Androgenic effects included a decrease in sex hormone binding globulin and HDL cholesterol. Bone turnover showed inconsistent responses. Among markers of bone formation, bone specific alkaline phosphatase decreased significantly by 23% while procollagen peptides and osteocalcin showed a non-significant increase. The marker of bone resorption, N-telopeptide crosslinks of collagen, decreased by 19% at 6 weeks. These results indicate that NETA does not have a potent short-term anabolic effect on bone but does have effects that are likely to be mediated through the estrogen and androgen receptors.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Lowell P. Weicker, General Clinical Research Center, University of Connecticut Health Center, Farmington, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11794470

Citation

Onobrakpeya, O A., et al. "Effect of Norethindrone Acetate On Hormone Levels and Markers of Bone Turnover in Estrogen-treated Postmenopausal Women." Endocrine Research, vol. 27, no. 4, 2001, pp. 473-80.
Onobrakpeya OA, Fall PM, Willard A, et al. Effect of norethindrone acetate on hormone levels and markers of bone turnover in estrogen-treated postmenopausal women. Endocr Res. 2001;27(4):473-80.
Onobrakpeya, O. A., Fall, P. M., Willard, A., Chakravarthi, P., Hansen, A., & Raisz, L. G. (2001). Effect of norethindrone acetate on hormone levels and markers of bone turnover in estrogen-treated postmenopausal women. Endocrine Research, 27(4), 473-80.
Onobrakpeya OA, et al. Effect of Norethindrone Acetate On Hormone Levels and Markers of Bone Turnover in Estrogen-treated Postmenopausal Women. Endocr Res. 2001;27(4):473-80. PubMed PMID: 11794470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of norethindrone acetate on hormone levels and markers of bone turnover in estrogen-treated postmenopausal women. AU - Onobrakpeya,O A, AU - Fall,P M, AU - Willard,A, AU - Chakravarthi,P, AU - Hansen,A, AU - Raisz,L G, PY - 2002/1/17/pubmed PY - 2002/6/25/medline PY - 2002/1/17/entrez SP - 473 EP - 80 JF - Endocrine research JO - Endocr. Res. VL - 27 IS - 4 N2 - There is controversy concerning the effects of progestins on bone. Norethindrone acetate (NETA) is synthetic progesterone that also has estrogenic and androgenic effects. We tested its effects on hormone levels, lipids and biochemical markers of bone turnover in postmenopausal women who were on estrogen replacement therapy. Women were treated with NETA, 5 mg/d for 9 weeks. Estrogenic effects included a marked lowering of follicle stimulating hormone and luteinizing hormone. Androgenic effects included a decrease in sex hormone binding globulin and HDL cholesterol. Bone turnover showed inconsistent responses. Among markers of bone formation, bone specific alkaline phosphatase decreased significantly by 23% while procollagen peptides and osteocalcin showed a non-significant increase. The marker of bone resorption, N-telopeptide crosslinks of collagen, decreased by 19% at 6 weeks. These results indicate that NETA does not have a potent short-term anabolic effect on bone but does have effects that are likely to be mediated through the estrogen and androgen receptors. SN - 0743-5800 UR - https://www.unboundmedicine.com/medline/citation/11794470/Effect_of_norethindrone_acetate_on_hormone_levels_and_markers_of_bone_turnover_in_estrogen_treated_postmenopausal_women_ L2 - http://www.tandfonline.com/doi/full/10.1081/erc-100107870 DB - PRIME DP - Unbound Medicine ER -