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Bone marrow as a source of endothelial cells for natural and iatrogenic vascular repair.

Abstract

Postnatal neovascularization has previously been considered synonymous with angiogenesis, but the finding that circulating endothelial progenitor cells (EPCs) may home to sites of neovascularization and there differentiate into endothelial cells (ECs) is consistent with "vasculogenesis," through which the primordial vascular network is established in the embryo. Our findings suggest that growth and development of new blood vessels in the adult are not restricted to angiogenesis but encompass vasculogenesis as well, although the proportional contributions remain to be clarified. Likewise, augmented or retarded neovascularization probably involves enhancement or impariment of the vasculogenesis process.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA. asa777@aol.com

    , ,

    Source

    MeSH

    Animals
    Bone Marrow Transplantation
    Endothelium, Vascular
    Humans
    Neovascularization, Physiologic
    Postoperative Complications
    Vascular Diseases
    Vascular Surgical Procedures

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.
    Review

    Language

    eng

    PubMed ID

    11795425

    Citation

    TY - JOUR T1 - Bone marrow as a source of endothelial cells for natural and iatrogenic vascular repair. AU - Isner,J M, AU - Kalka,C, AU - Kawamoto,A, AU - Asahara,T, PY - 2002/1/25/pubmed PY - 2002/2/5/medline PY - 2002/1/25/entrez SP - 75 EP - 84 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 953 N2 - Postnatal neovascularization has previously been considered synonymous with angiogenesis, but the finding that circulating endothelial progenitor cells (EPCs) may home to sites of neovascularization and there differentiate into endothelial cells (ECs) is consistent with "vasculogenesis," through which the primordial vascular network is established in the embryo. Our findings suggest that growth and development of new blood vessels in the adult are not restricted to angiogenesis but encompass vasculogenesis as well, although the proportional contributions remain to be clarified. Likewise, augmented or retarded neovascularization probably involves enhancement or impariment of the vasculogenesis process. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/11795425/full_citation/Bone_marrow_as_a_source_of_endothelial_cells_for_natural_and_iatrogenic_vascular_repair_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0077-8923&date=2001&volume=953&spage=75 ER -