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Chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis and neurological controls.
Mult Scler 2001; 7(6):371-4MS

Abstract

Chlamydia pneumoniae infection is a common event in neurological patients and recovery of C. pneumoniae DNA in the cerebrospinal fluids (CSF) of multiple sclerosis (MS) patients could represent an epiphenomenon. We assessed the relevance of C. pneumoniae infection in 62 CSF samples from 32 MS patients and 30 neurological controls by means of PCR, immunofluorescence microscopy, enzyme-linked fluorescence and antibody detection. Multiple sclerosis (9.3%) and neurological controls (13.3) had similar percentage of anti-C. pneumoniae antibodies. However, C. pneumoniae DNA was only detectable in MS patients' CSF (9.3%). Our data support the hypothesis that C. pneumoniae persistence in some MS patients may be the result of an impaired clearance within the central nervous system.

Authors+Show Affiliations

Istituto di Clinica Neurologica, Università di Sassari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11795458

Citation

Sotgiu, S, et al. "Chlamydia Pneumoniae in the Cerebrospinal Fluid of Patients With Multiple Sclerosis and Neurological Controls." Multiple Sclerosis (Houndmills, Basingstoke, England), vol. 7, no. 6, 2001, pp. 371-4.
Sotgiu S, Piana A, Pugliatti M, et al. Chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis and neurological controls. Mult Scler. 2001;7(6):371-4.
Sotgiu, S., Piana, A., Pugliatti, M., Sotgiu, A., Deiana, G. A., Sgaramella, E., ... Rosati, G. (2001). Chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis and neurological controls. Multiple Sclerosis (Houndmills, Basingstoke, England), 7(6), pp. 371-4.
Sotgiu S, et al. Chlamydia Pneumoniae in the Cerebrospinal Fluid of Patients With Multiple Sclerosis and Neurological Controls. Mult Scler. 2001;7(6):371-4. PubMed PMID: 11795458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis and neurological controls. AU - Sotgiu,S, AU - Piana,A, AU - Pugliatti,M, AU - Sotgiu,A, AU - Deiana,G A, AU - Sgaramella,E, AU - Muresu,E, AU - Rosati,G, PY - 2002/1/25/pubmed PY - 2002/6/12/medline PY - 2002/1/25/entrez SP - 371 EP - 4 JF - Multiple sclerosis (Houndmills, Basingstoke, England) JO - Mult. Scler. VL - 7 IS - 6 N2 - Chlamydia pneumoniae infection is a common event in neurological patients and recovery of C. pneumoniae DNA in the cerebrospinal fluids (CSF) of multiple sclerosis (MS) patients could represent an epiphenomenon. We assessed the relevance of C. pneumoniae infection in 62 CSF samples from 32 MS patients and 30 neurological controls by means of PCR, immunofluorescence microscopy, enzyme-linked fluorescence and antibody detection. Multiple sclerosis (9.3%) and neurological controls (13.3) had similar percentage of anti-C. pneumoniae antibodies. However, C. pneumoniae DNA was only detectable in MS patients' CSF (9.3%). Our data support the hypothesis that C. pneumoniae persistence in some MS patients may be the result of an impaired clearance within the central nervous system. SN - 1352-4585 UR - https://www.unboundmedicine.com/medline/citation/11795458/Chlamydia_pneumoniae_in_the_cerebrospinal_fluid_of_patients_with_multiple_sclerosis_and_neurological_controls_ L2 - http://journals.sagepub.com/doi/full/10.1177/135245850100700605?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -