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[The relationship between bone mineral density and polymorphism of the estrogen receptor gene in Chinese healthy menopausal women].
Zhonghua Nei Ke Za Zhi. 2000 Nov; 39(11):743-5.ZN

Abstract

OBJECTIVE

To investigate the possible relationship between bone mineral density (BMD) and polymorphism of the estrogen receptor (ER) gene in Chinese healthy postmenopausal women.

METHODS

237 unrelated healthy postmenopausal women were selected for bone mineral density determination with Dual energy X-ray absorptiometry (DEXA) and the polymorphism of estrogen receptor gene were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

RESULTS

It is shown that the distribution of ER genotype in the ER gene was as follows: PP 19.8%, Pp 44.3% and pp 35.9% respectively. ANOVA analysis indicated that BMD of trochanter major (Troch) was associated with polymorphism of ER gene (P = 0.0106). Multiple stepwise regression analysis showed that the relationship between polymorphism of ER gene and BMD of Troch (P = 0.0548) and lumbar vertebra 2 approximately 4 (P = 0.0998) was not statistically significant.

CONCLUSION

It is suggested that there is a significant relationship between polymorphism of ER gene and Troch BMD in healthy postmenopausal women. p allele may be a protective factor for bone mass loss.

Authors+Show Affiliations

Department of Osteoporosis, The Sixth People's Hospital of Shanghai, Shanghai 200233, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11798534

Citation

Wang, Q, et al. "[The Relationship Between Bone Mineral Density and Polymorphism of the Estrogen Receptor Gene in Chinese Healthy Menopausal Women]." Zhonghua Nei Ke Za Zhi, vol. 39, no. 11, 2000, pp. 743-5.
Wang Q, Huang Q, Zhou Q. [The relationship between bone mineral density and polymorphism of the estrogen receptor gene in Chinese healthy menopausal women]. Zhonghua Nei Ke Za Zhi. 2000;39(11):743-5.
Wang, Q., Huang, Q., & Zhou, Q. (2000). [The relationship between bone mineral density and polymorphism of the estrogen receptor gene in Chinese healthy menopausal women]. Zhonghua Nei Ke Za Zhi, 39(11), 743-5.
Wang Q, Huang Q, Zhou Q. [The Relationship Between Bone Mineral Density and Polymorphism of the Estrogen Receptor Gene in Chinese Healthy Menopausal Women]. Zhonghua Nei Ke Za Zhi. 2000;39(11):743-5. PubMed PMID: 11798534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The relationship between bone mineral density and polymorphism of the estrogen receptor gene in Chinese healthy menopausal women]. AU - Wang,Q, AU - Huang,Q, AU - Zhou,Q, PY - 2002/1/19/pubmed PY - 2002/2/12/medline PY - 2002/1/19/entrez SP - 743 EP - 5 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 39 IS - 11 N2 - OBJECTIVE: To investigate the possible relationship between bone mineral density (BMD) and polymorphism of the estrogen receptor (ER) gene in Chinese healthy postmenopausal women. METHODS: 237 unrelated healthy postmenopausal women were selected for bone mineral density determination with Dual energy X-ray absorptiometry (DEXA) and the polymorphism of estrogen receptor gene were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: It is shown that the distribution of ER genotype in the ER gene was as follows: PP 19.8%, Pp 44.3% and pp 35.9% respectively. ANOVA analysis indicated that BMD of trochanter major (Troch) was associated with polymorphism of ER gene (P = 0.0106). Multiple stepwise regression analysis showed that the relationship between polymorphism of ER gene and BMD of Troch (P = 0.0548) and lumbar vertebra 2 approximately 4 (P = 0.0998) was not statistically significant. CONCLUSION: It is suggested that there is a significant relationship between polymorphism of ER gene and Troch BMD in healthy postmenopausal women. p allele may be a protective factor for bone mass loss. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/11798534/[The_relationship_between_bone_mineral_density_and_polymorphism_of_the_estrogen_receptor_gene_in_Chinese_healthy_menopausal_women]_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -