TY - JOUR T1 - [The relationship between bone mineral density and polymorphism of the estrogen receptor gene in Chinese healthy menopausal women]. AU - Wang,Q, AU - Huang,Q, AU - Zhou,Q, PY - 2002/1/19/pubmed PY - 2002/2/12/medline PY - 2002/1/19/entrez SP - 743 EP - 5 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 39 IS - 11 N2 - OBJECTIVE: To investigate the possible relationship between bone mineral density (BMD) and polymorphism of the estrogen receptor (ER) gene in Chinese healthy postmenopausal women. METHODS: 237 unrelated healthy postmenopausal women were selected for bone mineral density determination with Dual energy X-ray absorptiometry (DEXA) and the polymorphism of estrogen receptor gene were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: It is shown that the distribution of ER genotype in the ER gene was as follows: PP 19.8%, Pp 44.3% and pp 35.9% respectively. ANOVA analysis indicated that BMD of trochanter major (Troch) was associated with polymorphism of ER gene (P = 0.0106). Multiple stepwise regression analysis showed that the relationship between polymorphism of ER gene and BMD of Troch (P = 0.0548) and lumbar vertebra 2 approximately 4 (P = 0.0998) was not statistically significant. CONCLUSION: It is suggested that there is a significant relationship between polymorphism of ER gene and Troch BMD in healthy postmenopausal women. p allele may be a protective factor for bone mass loss. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/11798534/[The_relationship_between_bone_mineral_density_and_polymorphism_of_the_estrogen_receptor_gene_in_Chinese_healthy_menopausal_women]_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -