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[The clinical significance of true insulin and proinsulin levels in subjects with different glucose tolerance].
Zhonghua Nei Ke Za Zhi. 2000 Dec; 39(12):811-3.ZN

Abstract

OBJECTIVE

To examine the levels of serum true insulin (TI) and proinsulin (PI) in individuals with different glucose tolerance and to assess its clinical significance.

METHODS

The levels of true insulin and proinsulin during oral glucose tolerance test (OGTT) were determined with specific BA-ELISA in 135 normal glucose tolerance (NGT) and 86 impaired glucose tolerance (IGT) subjects as well as 101 type II diabetes mellitus (DM) patients.

RESULTS

The fasting TI levels showed no significant difference (P > 0.05) among the groups of NGT, IGT and type II DM, but the immunoreactive insulin (IRI) concentration increased significantly in type II DM patients as compared with that in NGT (P < 0.01). Both of the fasting PI levels and the ratio of PI/(PI + TI) were significantly higher in type II DM patients as compared with those in NGT or IGT. The area under the curve of TI (AUC(TI)) was significantly higher (P < 0.05) in IGT than NGT and type II DM. Obese subjects had higher TI levels (P < 0.01) and lower insulin sensitivity (P < 0.05) than those in non-obese, while the ratio of PI/(PI + TI) and AUC(TI) was not significantly different statistically (P > 0.05) between the obese and non-obese subjects.

CONCLUSION

Type II DM patients present hyperproinsulinemia rather than hyperinsulinemia and have higher ratio of PI/(PI + TI) as compared with NGT and IGT subjects. Higher TI level and significant insulin resistance were observed in obese subjects, but there is no difference of the PI/(PI + TI) ratio. The fasting PI level and PI/(PI + TI) ratio tend to be the indexes of beta-cell dysfunction.

Authors+Show Affiliations

Department of Endocrinology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11798541

Citation

Yang, J, et al. "[The Clinical Significance of True Insulin and Proinsulin Levels in Subjects With Different Glucose Tolerance]." Zhonghua Nei Ke Za Zhi, vol. 39, no. 12, 2000, pp. 811-3.
Yang J, Li M, Wu C. [The clinical significance of true insulin and proinsulin levels in subjects with different glucose tolerance]. Zhonghua Nei Ke Za Zhi. 2000;39(12):811-3.
Yang, J., Li, M., & Wu, C. (2000). [The clinical significance of true insulin and proinsulin levels in subjects with different glucose tolerance]. Zhonghua Nei Ke Za Zhi, 39(12), 811-3.
Yang J, Li M, Wu C. [The Clinical Significance of True Insulin and Proinsulin Levels in Subjects With Different Glucose Tolerance]. Zhonghua Nei Ke Za Zhi. 2000;39(12):811-3. PubMed PMID: 11798541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The clinical significance of true insulin and proinsulin levels in subjects with different glucose tolerance]. AU - Yang,J, AU - Li,M, AU - Wu,C, PY - 2002/1/19/pubmed PY - 2003/7/11/medline PY - 2002/1/19/entrez SP - 811 EP - 3 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 39 IS - 12 N2 - OBJECTIVE: To examine the levels of serum true insulin (TI) and proinsulin (PI) in individuals with different glucose tolerance and to assess its clinical significance. METHODS: The levels of true insulin and proinsulin during oral glucose tolerance test (OGTT) were determined with specific BA-ELISA in 135 normal glucose tolerance (NGT) and 86 impaired glucose tolerance (IGT) subjects as well as 101 type II diabetes mellitus (DM) patients. RESULTS: The fasting TI levels showed no significant difference (P > 0.05) among the groups of NGT, IGT and type II DM, but the immunoreactive insulin (IRI) concentration increased significantly in type II DM patients as compared with that in NGT (P < 0.01). Both of the fasting PI levels and the ratio of PI/(PI + TI) were significantly higher in type II DM patients as compared with those in NGT or IGT. The area under the curve of TI (AUC(TI)) was significantly higher (P < 0.05) in IGT than NGT and type II DM. Obese subjects had higher TI levels (P < 0.01) and lower insulin sensitivity (P < 0.05) than those in non-obese, while the ratio of PI/(PI + TI) and AUC(TI) was not significantly different statistically (P > 0.05) between the obese and non-obese subjects. CONCLUSION: Type II DM patients present hyperproinsulinemia rather than hyperinsulinemia and have higher ratio of PI/(PI + TI) as compared with NGT and IGT subjects. Higher TI level and significant insulin resistance were observed in obese subjects, but there is no difference of the PI/(PI + TI) ratio. The fasting PI level and PI/(PI + TI) ratio tend to be the indexes of beta-cell dysfunction. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/11798541/[The_clinical_significance_of_true_insulin_and_proinsulin_levels_in_subjects_with_different_glucose_tolerance]_ L2 - https://antibodies.cancer.gov/detail/CPTC-SERPINA1-1 DB - PRIME DP - Unbound Medicine ER -