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[Effect of thyroxine upon prevention of recurrence of Graves' disease treated with antithyroid drugs].
Zhonghua Yi Xue Za Zhi. 2001 Mar 10; 81(5):274-5.ZY

Abstract

OBJECTIVE

To investigate the effect of thyroxine upon the prevention of recurrence of Graves disease after treatment by antithyroid drugs.

METHODS

Sixty patients newly diagnosed as Graves disease were treated with methimazole for 6 months and then randomly distributed into three groups. Patient in group A and group C received small dose of methimazole plus L-T(4) 50 microgram/d, and patients in group B were treated with methimazole in small dose only. Twenty four months later, only L-T(4) 50 microgram/d, without methimazole, was administered to the patients of group A; methimazole in maintenance dose was administered continuously to the patients of group B, and patients in group C were treated with methimazole in maintenance dose plus L-T(4) 50 microgram/d. Such treatments lasted 6 months. Post-treatment follow-up survey was conducted to the three groups.

RESULTS

The titers of thyroid-stimulating Ab (TSAb) in groups A and C were lower than that in group B. However, the recurrence rates among the three groups (4/20, 20%; 4/20, 25%; and 4/20, 20% respectively) were not significantly different.

CONCLUSION

Both treatment of Graves' disease with methimazole plus L-T4 and treatment with prolonged use of methimazole cannot reduce the recurrence rate more effectively than treatment with only methimazole. The level of TSAb is not the only factor that influences the recurrence of Graves disease.

Authors+Show Affiliations

Department of Endocrinology, Hospital Affiliated to Guangdong Medical College, Zhanjiang 524001, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

11798886

Citation

Wu, G, et al. "[Effect of Thyroxine Upon Prevention of Recurrence of Graves' Disease Treated With Antithyroid Drugs]." Zhonghua Yi Xue Za Zhi, vol. 81, no. 5, 2001, pp. 274-5.
Wu G, Jie Y, Situ Y. [Effect of thyroxine upon prevention of recurrence of Graves' disease treated with antithyroid drugs]. Zhonghua Yi Xue Za Zhi. 2001;81(5):274-5.
Wu, G., Jie, Y., & Situ, Y. (2001). [Effect of thyroxine upon prevention of recurrence of Graves' disease treated with antithyroid drugs]. Zhonghua Yi Xue Za Zhi, 81(5), 274-5.
Wu G, Jie Y, Situ Y. [Effect of Thyroxine Upon Prevention of Recurrence of Graves' Disease Treated With Antithyroid Drugs]. Zhonghua Yi Xue Za Zhi. 2001 Mar 10;81(5):274-5. PubMed PMID: 11798886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of thyroxine upon prevention of recurrence of Graves' disease treated with antithyroid drugs]. AU - Wu,G, AU - Jie,Y, AU - Situ,Y, PY - 2002/1/19/pubmed PY - 2002/4/20/medline PY - 2002/1/19/entrez SP - 274 EP - 5 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 81 IS - 5 N2 - OBJECTIVE: To investigate the effect of thyroxine upon the prevention of recurrence of Graves disease after treatment by antithyroid drugs. METHODS: Sixty patients newly diagnosed as Graves disease were treated with methimazole for 6 months and then randomly distributed into three groups. Patient in group A and group C received small dose of methimazole plus L-T(4) 50 microgram/d, and patients in group B were treated with methimazole in small dose only. Twenty four months later, only L-T(4) 50 microgram/d, without methimazole, was administered to the patients of group A; methimazole in maintenance dose was administered continuously to the patients of group B, and patients in group C were treated with methimazole in maintenance dose plus L-T(4) 50 microgram/d. Such treatments lasted 6 months. Post-treatment follow-up survey was conducted to the three groups. RESULTS: The titers of thyroid-stimulating Ab (TSAb) in groups A and C were lower than that in group B. However, the recurrence rates among the three groups (4/20, 20%; 4/20, 25%; and 4/20, 20% respectively) were not significantly different. CONCLUSION: Both treatment of Graves' disease with methimazole plus L-T4 and treatment with prolonged use of methimazole cannot reduce the recurrence rate more effectively than treatment with only methimazole. The level of TSAb is not the only factor that influences the recurrence of Graves disease. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/11798886/[Effect_of_thyroxine_upon_prevention_of_recurrence_of_Graves'_disease_treated_with_antithyroid_drugs]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0376-2491&year=2001&vol=81&issue=5&fpage=274 DB - PRIME DP - Unbound Medicine ER -