[The predication of ovarian response in control ovarian hyperstimulation by the ratio of basal FSH and LH level].Zhonghua Yi Xue Za Zhi. 2001 Jul 10; 81(13):819-21.ZY
To study the basal FSH/LH ratio and its changes to prognosticate the ovary reserve.
891 regularly cycling patients (IVF) participate. They were divided into three groups (the cancellation group which included using gonadotrophins one week later, there were 3 or less follicles to growth on ultrasound examination: 70cycles; the low response group defined as the collection of fewer or equal than 4 oocytes: 56 cycles; normally response group, the collection of more then 4 oocytes: 765 cycles). On the menstruation day 2 - 3 (basal level) and after using GnRHa, serum follicle stimulating hormone (FSH), luteinzing hormone (LH) and estradiol (E2) were demonstrated by immunoassay and analyzed by SPSS, the dose of gonadotrophins (Gn) and the treatment.
The basal FSH levels of cancellation group (9.7 IU/L +/- 7.8 IU/L), the low response group (7.8 IU/L +/- 5.4 IU/L), and normally response group (6.4 IU/L +/- 2.0 IU/L) have significant difference in the three groups P < 0.001. The basal FSH/LH ratio of the cancellation group (2.9), the low response group (2.0), and normally response group (1.6) have significant difference P < 0.05. And after using GnRHa, the 1 - 3 day of menstruation and before starting of Gn, the FSH/LH ratio became more higher in the cancellation group and the low responder group, FSH/LH > 5 and 4 respectively, the normally response group FSH/LH < 3, also there were significantly difference between them P < 0.001. The basal E2 levels in the normal response group were significantly lower than that in the low responder group.
The data suggest that although serum FSH level on D2-D3 doesn't reach 15IU/L, the basal FSH/LH > 2. After using GnRHa, the FSH/LH ratio became significantly higher, and the basal E2 level is higher, which is useful in prognostic assessment of ovarian bad reserve.