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Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis.

Abstract

OBJECTIVES

To compare the efficacy and tolerability of butterbur (Petasites hybridus) with cetirizine in patients with seasonal allergic rhinitis (hay fever).

DESIGN

Randomised, double blind, parallel group comparison.

SETTING

Four outpatient general medicine and allergy clinics in Switzerland and Germany.

PARTICIPANTS

131 patients were screened for seasonal allergic rhinitis and 125 patients were randomised (butterbur 61; cetirizine 64).

INTERVENTIONS

Butterbur (carbon dioxide extract tablets, ZE 339) one tablet, four times daily, or cetirizine, one tablet in the evening, both given for two consecutive weeks.

MAIN OUTCOME MEASURES

Scores on SF-36 questionnaire and clinical global impression scale.

RESULTS

Improvement in SF-36 score was similar in the two treatment groups for all items tested hierarchically. Butterbur and cetirizine were also similarly effective with regard to global improvement scores on the clinical global impression scale (median score 3 in both groups). Both treatments were well tolerated. In the cetirizine group, two thirds (8/12) of reported adverse events were associated with sedative effects (drowsiness and fatigue) despite the drug being considered a non-sedating antihistamine.

CONCLUSIONS

The effects of butterbur are similar to those of cetirizine in patients with seasonal allergic rhinitis when evaluated blindly by patients and doctors. Butterbur should be considered for treating seasonal allergic rhinitis when the sedative effects of antihistamines need to be avoided.

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  • Authors+Show Affiliations

    ,

    Allergy Clinic, Hochwangstrasse 3, CH-7302 Landquart, Switzerland. andreas.schapowal@freesurf.ch

    Source

    BMJ (Clinical research ed.) 324:7330 2002 Jan 19 pg 144-6

    MeSH

    Adult
    Asteraceae
    Cetirizine
    Fatigue
    Female
    Histamine H1 Antagonists
    Humans
    Male
    Middle Aged
    Patient Satisfaction
    Phytotherapy
    Plant Extracts
    Rhinitis, Allergic, Seasonal
    Sleep Stages
    Statistics, Nonparametric
    Treatment Outcome

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11799030

    Citation

    Schapowal, Andreas, and Petasites Study Group. "Randomised Controlled Trial of Butterbur and Cetirizine for Treating Seasonal Allergic Rhinitis." BMJ (Clinical Research Ed.), vol. 324, no. 7330, 2002, pp. 144-6.
    Schapowal A, Petasites Study Group. Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ. 2002;324(7330):144-6.
    Schapowal, A. (2002). Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ (Clinical Research Ed.), 324(7330), pp. 144-6.
    Schapowal A, Petasites Study Group. Randomised Controlled Trial of Butterbur and Cetirizine for Treating Seasonal Allergic Rhinitis. BMJ. 2002 Jan 19;324(7330):144-6. PubMed PMID: 11799030.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. AU - Schapowal,Andreas, AU - ,, PY - 2002/1/19/pubmed PY - 2002/2/14/medline PY - 2002/1/19/entrez SP - 144 EP - 6 JF - BMJ (Clinical research ed.) JO - BMJ VL - 324 IS - 7330 N2 - OBJECTIVES: To compare the efficacy and tolerability of butterbur (Petasites hybridus) with cetirizine in patients with seasonal allergic rhinitis (hay fever). DESIGN: Randomised, double blind, parallel group comparison. SETTING: Four outpatient general medicine and allergy clinics in Switzerland and Germany. PARTICIPANTS: 131 patients were screened for seasonal allergic rhinitis and 125 patients were randomised (butterbur 61; cetirizine 64). INTERVENTIONS: Butterbur (carbon dioxide extract tablets, ZE 339) one tablet, four times daily, or cetirizine, one tablet in the evening, both given for two consecutive weeks. MAIN OUTCOME MEASURES: Scores on SF-36 questionnaire and clinical global impression scale. RESULTS: Improvement in SF-36 score was similar in the two treatment groups for all items tested hierarchically. Butterbur and cetirizine were also similarly effective with regard to global improvement scores on the clinical global impression scale (median score 3 in both groups). Both treatments were well tolerated. In the cetirizine group, two thirds (8/12) of reported adverse events were associated with sedative effects (drowsiness and fatigue) despite the drug being considered a non-sedating antihistamine. CONCLUSIONS: The effects of butterbur are similar to those of cetirizine in patients with seasonal allergic rhinitis when evaluated blindly by patients and doctors. Butterbur should be considered for treating seasonal allergic rhinitis when the sedative effects of antihistamines need to be avoided. SN - 0959-8138 UR - https://www.unboundmedicine.com/medline/citation/11799030/full_citation L2 - http://www.bmj.com/cgi/pmidlookup?view=long&pmid=11799030 DB - PRIME DP - Unbound Medicine ER -