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Creutzfeldt-Jakob disease : report of 10 cases from North India.
Neurol India. 2001 Dec; 49(4):338-41.NI

Abstract

Creutzfeldt-Jakob disease (CJD) is increasingly being reported over the last three decades as a result of heightened awareness of the disease. Various studies have reported annual incidence of 0.5-1.5 cases of CJD per million of general population. In India, the disease is still under reported. Over the period spanning from 1968-1997, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore recorded 69 cases of CJD from different parts of India in the CJD registry. This paper describes the clinical experience with cases of CJD managed at the Department of Neurology, G.B. Pant Hospital, New Delhi from 1990-1998. In this series, the mean age of the patients was 53.80 (+/- 7.32) years and there were 5 females and 5 males. Myoclonus was present in all the cases and abnormal behaviour with or without other features was the presenting complaint in 7 of the 10 patients, while one patient of CJD had cerebellar ataxia as the presenting feature. One patient with occipital variant of CJD presented with acute onset cortical blindness and myoclonic jerks. One of the patients had acute psychosis precipitated by emotional stress at the onset. Extrapyramidal features were noted in 7 of the 10 patients before death. The mean duration of symptoms from the onset of disease to death was 6.6 (+/- 6.11) months. Classical EEG changes were observed in all the patients, except in one possible case of occipital variant of CJD, where we did not have access to EEG record. Brain biopsy could be undertaken in 3 patients, and in 2 patients the features of subacute spongiform encephalopathy (SSE) were noted.

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Authors+Show Affiliations

Mehndiratta MM
Department of Neurology, G.B. Pant Hospital, New Delhi-110002, India. mmehndi@vsnl.com
Bajaj BK
No affiliation info available
Gupta M
No affiliation info available
Anand R
No affiliation info available
Tatke M
No affiliation info available
Seryam S
No affiliation info available
Nehru R
No affiliation info available
Puri V
No affiliation info available
Khwaja GA
No affiliation info available

MeSH

AdultBehaviorBlindness, CorticalCerebellar AtaxiaCreutzfeldt-Jakob SyndromeFemaleHumansMaleMyoclonusPsychotic DisordersRetrospective Studies

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11799404

Citation

Mehndiratta, M M., et al. "Creutzfeldt-Jakob Disease : Report of 10 Cases From North India." Neurology India, vol. 49, no. 4, 2001, pp. 338-41.
Mehndiratta MM, Bajaj BK, Gupta M, et al. Creutzfeldt-Jakob disease : report of 10 cases from North India. Neurol India. 2001;49(4):338-41.
Mehndiratta, M. M., Bajaj, B. K., Gupta, M., Anand, R., Tatke, M., Seryam, S., Nehru, R., Puri, V., & Khwaja, G. A. (2001). Creutzfeldt-Jakob disease : report of 10 cases from North India. Neurology India, 49(4), 338-41.
Mehndiratta MM, et al. Creutzfeldt-Jakob Disease : Report of 10 Cases From North India. Neurol India. 2001;49(4):338-41. PubMed PMID: 11799404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Creutzfeldt-Jakob disease : report of 10 cases from North India. AU - Mehndiratta,M M, AU - Bajaj,B K, AU - Gupta,M, AU - Anand,R, AU - Tatke,M, AU - Seryam,S, AU - Nehru,R, AU - Puri,V, AU - Khwaja,G A, PY - 2002/1/19/pubmed PY - 2002/2/13/medline PY - 2002/1/19/entrez SP - 338 EP - 41 JF - Neurology India JO - Neurol India VL - 49 IS - 4 N2 - Creutzfeldt-Jakob disease (CJD) is increasingly being reported over the last three decades as a result of heightened awareness of the disease. Various studies have reported annual incidence of 0.5-1.5 cases of CJD per million of general population. In India, the disease is still under reported. Over the period spanning from 1968-1997, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore recorded 69 cases of CJD from different parts of India in the CJD registry. This paper describes the clinical experience with cases of CJD managed at the Department of Neurology, G.B. Pant Hospital, New Delhi from 1990-1998. In this series, the mean age of the patients was 53.80 (+/- 7.32) years and there were 5 females and 5 males. Myoclonus was present in all the cases and abnormal behaviour with or without other features was the presenting complaint in 7 of the 10 patients, while one patient of CJD had cerebellar ataxia as the presenting feature. One patient with occipital variant of CJD presented with acute onset cortical blindness and myoclonic jerks. One of the patients had acute psychosis precipitated by emotional stress at the onset. Extrapyramidal features were noted in 7 of the 10 patients before death. The mean duration of symptoms from the onset of disease to death was 6.6 (+/- 6.11) months. Classical EEG changes were observed in all the patients, except in one possible case of occipital variant of CJD, where we did not have access to EEG record. Brain biopsy could be undertaken in 3 patients, and in 2 patients the features of subacute spongiform encephalopathy (SSE) were noted. SN - 0028-3886 UR - https://www.unboundmedicine.com/medline/citation/11799404/Creutzfeldt_Jakob_disease_:_report_of_10_cases_from_North_India_ L2 - http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2001;volume=49;issue=4;spage=338;epage=41;aulast=Mehndiratta DB - PRIME DP - Unbound Medicine ER -