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Associations of lead biomarkers and delta-aminolevulinic acid dehydratase and vitamin D receptor genotypes with hematopoietic outcomes in Korean lead workers.
Scand J Work Environ Health. 2001 Dec; 27(6):402-11.SJ

Abstract

OBJECTIVES

This study compares and contrasts associations of dimercaptosuccinic acid (DMSA)-chelatable lead, tibia lead, and blood lead with five hematopoietic outcomes and evaluates the effect modification of these relations by polymorphisms in the delta-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes.

METHODS

A cross-sectional study of 798 lead workers and 135 unexposed referents was performed.

RESULTS

The DMSA-chelatable lead, tibia lead, and blood lead levels ranged in the lead (Pb) workers from 4.8 to 2103 g, -7 to 338 g Pb/g bone mineral, and 4 to 86 g/dl, respectively. The mean of the hemoglobin, hematocrit, zinc protoporphyrin (ZPP), and urinary (ALAU) and plasma (ALAP) delta-aminolevulinic acid levels of the lead workers were 14.2 (SD 1.4) g/dl, 42.4 (SD 4.4)%, 80.2 (SD 63.5) g/dl, 2.1 (SD 3.7) mg/l, and 17.7 (20.6) g/ml, respectively. After adjustment for the covariates, tibia lead was associated with all five hematopoietic outcomes, while blood lead and DMSA-chelatable lead were associated only with ZPP, ALAP, and ALAU. A comparison of the regression coefficients, total model adjusted R2 values, and delta R2 values revealed that blood lead was the best predictor of ZPP, ALAP, and ALAU. Only tibia lead was significantly associated with hemoglobin and hematocrit levels, but the additional variance explained by tibia lead was (<1%). No clear effect modification of the relations between the lead biomarkers and hematopoietic outcomes studied was caused by ALAD or VDR genotype.

CONCLUSIONS

Lead must have a chronic, cumulative effect on hemoglobin and hematocrit levels, and any speculated mechanism cannot merely involve short-term plasma or target organ lead levels.

Authors+Show Affiliations

Institute of Industrial Medicine, Soonchunhyang University, Chonan, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11800328

Citation

Lee, S S., et al. "Associations of Lead Biomarkers and Delta-aminolevulinic Acid Dehydratase and Vitamin D Receptor Genotypes With Hematopoietic Outcomes in Korean Lead Workers." Scandinavian Journal of Work, Environment & Health, vol. 27, no. 6, 2001, pp. 402-11.
Lee SS, Lee BK, Lee GS, et al. Associations of lead biomarkers and delta-aminolevulinic acid dehydratase and vitamin D receptor genotypes with hematopoietic outcomes in Korean lead workers. Scand J Work Environ Health. 2001;27(6):402-11.
Lee, S. S., Lee, B. K., Lee, G. S., Stewart, W. F., Simon, D., Kelsey, K., Todd, A. C., & Schwartz, B. S. (2001). Associations of lead biomarkers and delta-aminolevulinic acid dehydratase and vitamin D receptor genotypes with hematopoietic outcomes in Korean lead workers. Scandinavian Journal of Work, Environment & Health, 27(6), 402-11.
Lee SS, et al. Associations of Lead Biomarkers and Delta-aminolevulinic Acid Dehydratase and Vitamin D Receptor Genotypes With Hematopoietic Outcomes in Korean Lead Workers. Scand J Work Environ Health. 2001;27(6):402-11. PubMed PMID: 11800328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of lead biomarkers and delta-aminolevulinic acid dehydratase and vitamin D receptor genotypes with hematopoietic outcomes in Korean lead workers. AU - Lee,S S, AU - Lee,B K, AU - Lee,G S, AU - Stewart,W F, AU - Simon,D, AU - Kelsey,K, AU - Todd,A C, AU - Schwartz,B S, PY - 2002/1/22/pubmed PY - 2002/5/10/medline PY - 2002/1/22/entrez SP - 402 EP - 11 JF - Scandinavian journal of work, environment & health JO - Scand J Work Environ Health VL - 27 IS - 6 N2 - OBJECTIVES: This study compares and contrasts associations of dimercaptosuccinic acid (DMSA)-chelatable lead, tibia lead, and blood lead with five hematopoietic outcomes and evaluates the effect modification of these relations by polymorphisms in the delta-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes. METHODS: A cross-sectional study of 798 lead workers and 135 unexposed referents was performed. RESULTS: The DMSA-chelatable lead, tibia lead, and blood lead levels ranged in the lead (Pb) workers from 4.8 to 2103 g, -7 to 338 g Pb/g bone mineral, and 4 to 86 g/dl, respectively. The mean of the hemoglobin, hematocrit, zinc protoporphyrin (ZPP), and urinary (ALAU) and plasma (ALAP) delta-aminolevulinic acid levels of the lead workers were 14.2 (SD 1.4) g/dl, 42.4 (SD 4.4)%, 80.2 (SD 63.5) g/dl, 2.1 (SD 3.7) mg/l, and 17.7 (20.6) g/ml, respectively. After adjustment for the covariates, tibia lead was associated with all five hematopoietic outcomes, while blood lead and DMSA-chelatable lead were associated only with ZPP, ALAP, and ALAU. A comparison of the regression coefficients, total model adjusted R2 values, and delta R2 values revealed that blood lead was the best predictor of ZPP, ALAP, and ALAU. Only tibia lead was significantly associated with hemoglobin and hematocrit levels, but the additional variance explained by tibia lead was (<1%). No clear effect modification of the relations between the lead biomarkers and hematopoietic outcomes studied was caused by ALAD or VDR genotype. CONCLUSIONS: Lead must have a chronic, cumulative effect on hemoglobin and hematocrit levels, and any speculated mechanism cannot merely involve short-term plasma or target organ lead levels. SN - 0355-3140 UR - https://www.unboundmedicine.com/medline/citation/11800328/Associations_of_lead_biomarkers_and_delta_aminolevulinic_acid_dehydratase_and_vitamin_D_receptor_genotypes_with_hematopoietic_outcomes_in_Korean_lead_workers_ L2 - https://www.sjweh.fi/show_abstract.php?abstract_id=633 DB - PRIME DP - Unbound Medicine ER -