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Alzheimer's disease-do tauists and baptists finally shake hands?
Trends Neurosci. 2002 Jan; 25(1):22-6.TN

Abstract

The amyloid cascade hypothesis has been the predominant model of molecular pathogenesis in Alzheimer's disease. The finding of tau mutations in other dementias has added weight to the hypothesis as it suggests that tau-pathology is a downstream but essential part of the dementing process. However, some observations remain difficult to reconcile with the hypothesis. In transgenic mice, for example, amyloid generation does not induce the predicted cascade and in man, plaques and tangles are separated temporally and spatially. One alternative possibility is that some common factor, loss of wnt signalling for example, might induce both plaques and tangles.

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Authors+Show Affiliations

Mudher A
Depts of Neuroscience and Psychological Medicine, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK.
Lovestone S
No affiliation info available

MeSH

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsHumansMiceNeurofibrillary TanglesPlaque, AmyloidProto-Oncogene ProteinsSignal TransductionWnt ProteinsZebrafish Proteinstau Proteins

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11801334

Citation

Mudher, Amritpal, and Simon Lovestone. "Alzheimer's Disease-do Tauists and Baptists Finally Shake Hands?" Trends in Neurosciences, vol. 25, no. 1, 2002, pp. 22-6.
Mudher A, Lovestone S. Alzheimer's disease-do tauists and baptists finally shake hands? Trends Neurosci. 2002;25(1):22-6.
Mudher, A., & Lovestone, S. (2002). Alzheimer's disease-do tauists and baptists finally shake hands? Trends in Neurosciences, 25(1), 22-6.
Mudher A, Lovestone S. Alzheimer's Disease-do Tauists and Baptists Finally Shake Hands. Trends Neurosci. 2002;25(1):22-6. PubMed PMID: 11801334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alzheimer's disease-do tauists and baptists finally shake hands? AU - Mudher,Amritpal, AU - Lovestone,Simon, PY - 2002/1/22/pubmed PY - 2002/2/28/medline PY - 2002/1/22/entrez SP - 22 EP - 6 JF - Trends in neurosciences JO - Trends Neurosci VL - 25 IS - 1 N2 - The amyloid cascade hypothesis has been the predominant model of molecular pathogenesis in Alzheimer's disease. The finding of tau mutations in other dementias has added weight to the hypothesis as it suggests that tau-pathology is a downstream but essential part of the dementing process. However, some observations remain difficult to reconcile with the hypothesis. In transgenic mice, for example, amyloid generation does not induce the predicted cascade and in man, plaques and tangles are separated temporally and spatially. One alternative possibility is that some common factor, loss of wnt signalling for example, might induce both plaques and tangles. SN - 0166-2236 UR - https://www.unboundmedicine.com/medline/citation/11801334/Alzheimer's_disease_do_tauists_and_baptists_finally_shake_hands L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-2236(00)02031-2 DB - PRIME DP - Unbound Medicine ER -