Tags

Type your tag names separated by a space and hit enter

Study of the association between Alzheimer's disease and angiotensin-converting enzyme gene polymorphism using DNA from lymphocytes.
Eur Neurol 2002; 47(1):26-9EN

Abstract

Angiotensin-converting enzyme (ACE) may play a role in cognition and memory. A recent study found that a 287-bp insertion/deletion (I/D) polymorphism of the ACE gene is associated with susceptibility to Alzheimer's disease (AD). However, this finding has not been replicated by all studies. These discrepancies may be due to the difference in ethnic background. Therefore, we investigated the possibility of such an association in 173 AD patients and 286 normal controls from a Chinese population. We found that there is an increased frequency of the ACE I allele in AD patients and the odds ratio for bearers of the I allele was 2.88. Our findings further support previous reports of an association between ACE polymorphism and AD. The implication of the ACE I/D polymorphism in the pathogenesis of AD warrants further exploration.

Authors+Show Affiliations

Department of Psychiatry, Veterans General Hospital-Taipei, Taipei, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11803189

Citation

Cheng, Chih-Ya, et al. "Study of the Association Between Alzheimer's Disease and Angiotensin-converting Enzyme Gene Polymorphism Using DNA From Lymphocytes." European Neurology, vol. 47, no. 1, 2002, pp. 26-9.
Cheng CY, Hong CJ, Liu HC, et al. Study of the association between Alzheimer's disease and angiotensin-converting enzyme gene polymorphism using DNA from lymphocytes. Eur Neurol. 2002;47(1):26-9.
Cheng, C. Y., Hong, C. J., Liu, H. C., Liu, T. Y., & Tsai, S. J. (2002). Study of the association between Alzheimer's disease and angiotensin-converting enzyme gene polymorphism using DNA from lymphocytes. European Neurology, 47(1), pp. 26-9.
Cheng CY, et al. Study of the Association Between Alzheimer's Disease and Angiotensin-converting Enzyme Gene Polymorphism Using DNA From Lymphocytes. Eur Neurol. 2002;47(1):26-9. PubMed PMID: 11803189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of the association between Alzheimer's disease and angiotensin-converting enzyme gene polymorphism using DNA from lymphocytes. AU - Cheng,Chih-Ya, AU - Hong,Chen-Jee, AU - Liu,Hsiu-Chih, AU - Liu,Tsung-Yun, AU - Tsai,Shih-Jen, PY - 2002/1/23/pubmed PY - 2002/3/7/medline PY - 2002/1/23/entrez SP - 26 EP - 9 JF - European neurology JO - Eur. Neurol. VL - 47 IS - 1 N2 - Angiotensin-converting enzyme (ACE) may play a role in cognition and memory. A recent study found that a 287-bp insertion/deletion (I/D) polymorphism of the ACE gene is associated with susceptibility to Alzheimer's disease (AD). However, this finding has not been replicated by all studies. These discrepancies may be due to the difference in ethnic background. Therefore, we investigated the possibility of such an association in 173 AD patients and 286 normal controls from a Chinese population. We found that there is an increased frequency of the ACE I allele in AD patients and the odds ratio for bearers of the I allele was 2.88. Our findings further support previous reports of an association between ACE polymorphism and AD. The implication of the ACE I/D polymorphism in the pathogenesis of AD warrants further exploration. SN - 0014-3022 UR - https://www.unboundmedicine.com/medline/citation/11803189/Study_of_the_association_between_Alzheimer's_disease_and_angiotensin_converting_enzyme_gene_polymorphism_using_DNA_from_lymphocytes_ L2 - https://www.karger.com?DOI=10.1159/000047943 DB - PRIME DP - Unbound Medicine ER -