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[Distribution and spread of human African trypanosomiasis: value of genetic identification of the trypanosomes].
Med Trop (Mars). 2001; 61(4-5):433-6.MT

Abstract

Numerous factors extrinsic to trypanosome populations have been implicated in the distribution and spread of human African trypanosomiasis (HAT), but quantification of these factors has proven difficult. An easier method of monitoring HAT consists of tracking parasites by genetic identification of trypanosomes in hosts and vectors. This method requires distinction between Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense followed by determination of the genotype of each subspecies in the host and vector. The role of vertebrate hosts in the distribution and spread of HAT has been confirmed by genetic identification of trypanosomes. Despite the ever-improving performance of biomolecular techniques, identification must be carried out on natural populations actually circulating in the biological fluids of the host and vector. This precaution is necessary to rule out the biasing effect of in vivo or in vitro isolation of trypanosomes.

Authors+Show Affiliations

Truc P
L'Unité de Recherche 035, l'Institut de Recherche pour le Développement, Yaoundé, Cameroun. truc@iccnet.cm
Cuny G
No affiliation info available

MeSH

AnimalsBody FluidsGenotypeHumansInsect VectorsParasitemiaTrypanosoma brucei gambienseTrypanosoma brucei rhodesienseTrypanosomiasis, AfricanTsetse Flies

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

11803837

Citation

Truc, P, and G Cuny. "[Distribution and Spread of Human African Trypanosomiasis: Value of Genetic Identification of the Trypanosomes]." Medecine Tropicale : Revue Du Corps De Sante Colonial, vol. 61, no. 4-5, 2001, pp. 433-6.
Truc P, Cuny G. [Distribution and spread of human African trypanosomiasis: value of genetic identification of the trypanosomes]. Med Trop (Mars). 2001;61(4-5):433-6.
Truc, P., & Cuny, G. (2001). [Distribution and spread of human African trypanosomiasis: value of genetic identification of the trypanosomes]. Medecine Tropicale : Revue Du Corps De Sante Colonial, 61(4-5), 433-6.
Truc P, Cuny G. [Distribution and Spread of Human African Trypanosomiasis: Value of Genetic Identification of the Trypanosomes]. Med Trop (Mars). 2001;61(4-5):433-6. PubMed PMID: 11803837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Distribution and spread of human African trypanosomiasis: value of genetic identification of the trypanosomes]. AU - Truc,P, AU - Cuny,G, PY - 2002/1/24/pubmed PY - 2002/2/13/medline PY - 2002/1/24/entrez SP - 433 EP - 6 JF - Medecine tropicale : revue du Corps de sante colonial JO - Med Trop (Mars) VL - 61 IS - 4-5 N2 - Numerous factors extrinsic to trypanosome populations have been implicated in the distribution and spread of human African trypanosomiasis (HAT), but quantification of these factors has proven difficult. An easier method of monitoring HAT consists of tracking parasites by genetic identification of trypanosomes in hosts and vectors. This method requires distinction between Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense followed by determination of the genotype of each subspecies in the host and vector. The role of vertebrate hosts in the distribution and spread of HAT has been confirmed by genetic identification of trypanosomes. Despite the ever-improving performance of biomolecular techniques, identification must be carried out on natural populations actually circulating in the biological fluids of the host and vector. This precaution is necessary to rule out the biasing effect of in vivo or in vitro isolation of trypanosomes. SN - 0025-682X UR - https://www.unboundmedicine.com/medline/citation/11803837/[Distribution_and_spread_of_human_African_trypanosomiasis:_value_of_genetic_identification_of_the_trypanosomes]_ DB - PRIME DP - Unbound Medicine ER -