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Epidemiology of anemia associated with chronic renal insufficiency among adults in the United States: results from the Third National Health and Nutrition Examination Survey.
J Am Soc Nephrol. 2002 Feb; 13(2):504-510.JA

Abstract

Anemia associated with chronic renal insufficiency (CRI) may have substantial clinical and public health importance, but little is known about its epidemiology. This study aims to quantify the relationship between reduced renal function and hemoglobin level, to assess the iron status of subjects with CRI, and to estimate the burden of anemia associated with CRI. The Third National Health and Nutrition Examination Survey (NHANES III) (1988 to 1994) data on 15,971 adults aged >18 yr with measurements of serum creatinine, hemoglobin, and iron profile were analyzed. General linear models were used to determine the relationship between hemoglobin level and Cockcroft-Gault creatinine clearance (CrCl) and to estimate the likelihood of anemia at different levels of renal function in different demographic subgroups. Sample weights were used to produce weighted regression parameters and population estimates. A statistically significant decrease in hemoglobin was apparent among men starting at CrCl < or =70 ml/min and among women starting at CrCl < or =50 ml/min. At any given level of CrCl, men had a larger decrease in hemoglobin than women. For example, compared with subjects with CrCl >80 ml/min, the decrease in hemoglobin for subjects with CrCl 20 to 30 ml/min was 1.0 g/dl in women and 1.4 g/dl in men. A substantial number of subjects with CRI might not have sufficient iron stores to support erythropoiesis as judged by the NKF-K/DOQI transferrin saturation or serum ferritin targets. Among those with CrCl 20 to 30 ml/min, 46% of women and 19% of men had transferrin saturation <20%, and 47% of women and 44% of men had serum ferritin <100 ng/ml. Results estimate that 13.5 million US adults had CrCl < or =50 ml/min. The overall burden of CRI associated anemia, defined as hemoglobin <11 g/dl, was 800,000 adults. The public health burden of anemia associated with CRI may be substantial, given the large number of people with CRI; and that even a modest reduction in renal function is associated with decreased hemoglobin level.

Authors+Show Affiliations

*Division of Nephrology, Division of Biostatistics, University of California, San Francisco, San Francisco, California; and Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.*Division of Nephrology, Division of Biostatistics, University of California, San Francisco, San Francisco, California; and Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.*Division of Nephrology, Division of Biostatistics, University of California, San Francisco, San Francisco, California; and Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11805181

Citation

Hsu, Chi-Yuan, et al. "Epidemiology of Anemia Associated With Chronic Renal Insufficiency Among Adults in the United States: Results From the Third National Health and Nutrition Examination Survey." Journal of the American Society of Nephrology : JASN, vol. 13, no. 2, 2002, pp. 504-510.
Hsu CY, McCulloch CE, Curhan GC. Epidemiology of anemia associated with chronic renal insufficiency among adults in the United States: results from the Third National Health and Nutrition Examination Survey. J Am Soc Nephrol. 2002;13(2):504-510.
Hsu, C. Y., McCulloch, C. E., & Curhan, G. C. (2002). Epidemiology of anemia associated with chronic renal insufficiency among adults in the United States: results from the Third National Health and Nutrition Examination Survey. Journal of the American Society of Nephrology : JASN, 13(2), 504-510. https://doi.org/10.1681/ASN.V132504
Hsu CY, McCulloch CE, Curhan GC. Epidemiology of Anemia Associated With Chronic Renal Insufficiency Among Adults in the United States: Results From the Third National Health and Nutrition Examination Survey. J Am Soc Nephrol. 2002;13(2):504-510. PubMed PMID: 11805181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of anemia associated with chronic renal insufficiency among adults in the United States: results from the Third National Health and Nutrition Examination Survey. AU - Hsu,Chi-Yuan, AU - McCulloch,Charles E, AU - Curhan,Gary C, PY - 2002/1/24/pubmed PY - 2002/3/14/medline PY - 2002/1/24/entrez SP - 504 EP - 510 JF - Journal of the American Society of Nephrology : JASN JO - J Am Soc Nephrol VL - 13 IS - 2 N2 - Anemia associated with chronic renal insufficiency (CRI) may have substantial clinical and public health importance, but little is known about its epidemiology. This study aims to quantify the relationship between reduced renal function and hemoglobin level, to assess the iron status of subjects with CRI, and to estimate the burden of anemia associated with CRI. The Third National Health and Nutrition Examination Survey (NHANES III) (1988 to 1994) data on 15,971 adults aged >18 yr with measurements of serum creatinine, hemoglobin, and iron profile were analyzed. General linear models were used to determine the relationship between hemoglobin level and Cockcroft-Gault creatinine clearance (CrCl) and to estimate the likelihood of anemia at different levels of renal function in different demographic subgroups. Sample weights were used to produce weighted regression parameters and population estimates. A statistically significant decrease in hemoglobin was apparent among men starting at CrCl < or =70 ml/min and among women starting at CrCl < or =50 ml/min. At any given level of CrCl, men had a larger decrease in hemoglobin than women. For example, compared with subjects with CrCl >80 ml/min, the decrease in hemoglobin for subjects with CrCl 20 to 30 ml/min was 1.0 g/dl in women and 1.4 g/dl in men. A substantial number of subjects with CRI might not have sufficient iron stores to support erythropoiesis as judged by the NKF-K/DOQI transferrin saturation or serum ferritin targets. Among those with CrCl 20 to 30 ml/min, 46% of women and 19% of men had transferrin saturation <20%, and 47% of women and 44% of men had serum ferritin <100 ng/ml. Results estimate that 13.5 million US adults had CrCl < or =50 ml/min. The overall burden of CRI associated anemia, defined as hemoglobin <11 g/dl, was 800,000 adults. The public health burden of anemia associated with CRI may be substantial, given the large number of people with CRI; and that even a modest reduction in renal function is associated with decreased hemoglobin level. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/11805181/Epidemiology_of_anemia_associated_with_chronic_renal_insufficiency_among_adults_in_the_United_States:_results_from_the_Third_National_Health_and_Nutrition_Examination_Survey_ L2 - https://jasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=11805181 DB - PRIME DP - Unbound Medicine ER -