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Homocysteine plasma levels are independently associated with insulin resistance in normal weight, overweight and obese pre-menopausal women.
Diabetes Nutr Metab. 2001 Oct; 14(5):253-8.DN

Abstract

OBJECTIVES

The aim of the present study was to examine the relationship of homocysteine (Hcy) plasma levels to insulin resistance (IR).

DESIGN

A cross-sectional study in a primary care setting.

SUBJECTS AND METHODS

Fasting Hcy levels were measured in the plasma of 44 pre-menopausal women [17 normal weight (body mass index BMI 20.0-24.9 kg/m2), 7 overweight (BMI 25.0-29.9 kg/m2), 20 obese (BMI> or =30.0 kg/m2)], aged 18-45 yr. Other measurements included: central fat accumulation, as evaluated by waist circumference; IR, as calculated by homeostatic model assessment (HOMAIR); systolic and diastolic blood pressure; and fasting concentrations of glucose, insulin and lipids (total cholesterol, HDL-cholesterol, triglycerides).

RESULTS

Hcy was positively correlated with insulin concentrations (p<0.01), HOMAIR (p<0.01), and systolic and diastolic blood pressure (p<0.01 and p<0.05, respectively). After multivariate analysis, only HOMAIR maintained an independent association with Hcy (p<0.05), irrespective of age and other anthropometric and biochemical variables. Lastly, we observed a gradual increase in Hcy plasma levels across the age- and BMI-matched quartiles in which the whole population was divided according to HOMAIR levels (F: 2.73, p<0.05 for linear trend).

CONCLUSIONS

Our study shows that Hcy plasma levels are independently associated with IR in apparently healthy normal weight, overweight and obese pre-menopausal women, thus suggesting a possible role of IR and/or hyperinsulinaemia in increasing Hcy plasma levels. Since Hcy is a well-known cardiovascular risk factor, higher Hcy plasma levels may well be a further mechanism explaining the higher risk of coronary heart disease in patients affected by IR.

Authors+Show Affiliations

Department of Emergency and Transplant, University of Bari, Italy. gdepergola@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11806465

Citation

De Pergola, G, et al. "Homocysteine Plasma Levels Are Independently Associated With Insulin Resistance in Normal Weight, Overweight and Obese Pre-menopausal Women." Diabetes, Nutrition & Metabolism, vol. 14, no. 5, 2001, pp. 253-8.
De Pergola G, Pannacciulli N, Zamboni M, et al. Homocysteine plasma levels are independently associated with insulin resistance in normal weight, overweight and obese pre-menopausal women. Diabetes Nutr Metab. 2001;14(5):253-8.
De Pergola, G., Pannacciulli, N., Zamboni, M., Minenna, A., Brocco, G., Sciaraffia, M., Bosello, ., & Giorgino, R. (2001). Homocysteine plasma levels are independently associated with insulin resistance in normal weight, overweight and obese pre-menopausal women. Diabetes, Nutrition & Metabolism, 14(5), 253-8.
De Pergola G, et al. Homocysteine Plasma Levels Are Independently Associated With Insulin Resistance in Normal Weight, Overweight and Obese Pre-menopausal Women. Diabetes Nutr Metab. 2001;14(5):253-8. PubMed PMID: 11806465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine plasma levels are independently associated with insulin resistance in normal weight, overweight and obese pre-menopausal women. AU - De Pergola,G, AU - Pannacciulli,N, AU - Zamboni,M, AU - Minenna,A, AU - Brocco,G, AU - Sciaraffia,M, AU - Bosello,, AU - Giorgino,R, PY - 2002/1/25/pubmed PY - 2002/8/16/medline PY - 2002/1/25/entrez SP - 253 EP - 8 JF - Diabetes, nutrition & metabolism JO - Diabetes Nutr Metab VL - 14 IS - 5 N2 - OBJECTIVES: The aim of the present study was to examine the relationship of homocysteine (Hcy) plasma levels to insulin resistance (IR). DESIGN: A cross-sectional study in a primary care setting. SUBJECTS AND METHODS: Fasting Hcy levels were measured in the plasma of 44 pre-menopausal women [17 normal weight (body mass index BMI 20.0-24.9 kg/m2), 7 overweight (BMI 25.0-29.9 kg/m2), 20 obese (BMI> or =30.0 kg/m2)], aged 18-45 yr. Other measurements included: central fat accumulation, as evaluated by waist circumference; IR, as calculated by homeostatic model assessment (HOMAIR); systolic and diastolic blood pressure; and fasting concentrations of glucose, insulin and lipids (total cholesterol, HDL-cholesterol, triglycerides). RESULTS: Hcy was positively correlated with insulin concentrations (p<0.01), HOMAIR (p<0.01), and systolic and diastolic blood pressure (p<0.01 and p<0.05, respectively). After multivariate analysis, only HOMAIR maintained an independent association with Hcy (p<0.05), irrespective of age and other anthropometric and biochemical variables. Lastly, we observed a gradual increase in Hcy plasma levels across the age- and BMI-matched quartiles in which the whole population was divided according to HOMAIR levels (F: 2.73, p<0.05 for linear trend). CONCLUSIONS: Our study shows that Hcy plasma levels are independently associated with IR in apparently healthy normal weight, overweight and obese pre-menopausal women, thus suggesting a possible role of IR and/or hyperinsulinaemia in increasing Hcy plasma levels. Since Hcy is a well-known cardiovascular risk factor, higher Hcy plasma levels may well be a further mechanism explaining the higher risk of coronary heart disease in patients affected by IR. SN - 0394-3402 UR - https://www.unboundmedicine.com/medline/citation/11806465/Homocysteine_plasma_levels_are_independently_associated_with_insulin_resistance_in_normal_weight_overweight_and_obese_pre_menopausal_women_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -