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What is the mechanism of carbon monoxide toxicity?
Aviat Space Environ Med. 1975 Oct; 46(10):1289-91.AS

Abstract

The probable toxic action is CO is on the cellular respiration, in which CO competes with O2 for cytochrome a3. Our studies indicate that a relatively high concentration of COHb (50%) does not interfere with the O2-carrying capacity of the blood. The dissolved CO in plasma, which is necessary for CO to enter the tissue, probably occurs when the exchange takes place between alveolar air and the blood in the lungs. This would explain why the central nervous system could be impaired when COHb levels are below 10% and death could occur at 35%.

Authors

Goldbaum LR
No affiliation info available
Ramirez RG
No affiliation info available
Absalon KB
No affiliation info available

MeSH

Aerospace MedicineAnemiaAnimalsCarbon MonoxideCarbon Monoxide PoisoningCarboxyhemoglobinDogsHemoglobinsOxygen Consumption

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1180795

Citation

Goldbaum, L R., et al. "What Is the Mechanism of Carbon Monoxide Toxicity?" Aviation, Space, and Environmental Medicine, vol. 46, no. 10, 1975, pp. 1289-91.
Goldbaum LR, Ramirez RG, Absalon KB. What is the mechanism of carbon monoxide toxicity? Aviat Space Environ Med. 1975;46(10):1289-91.
Goldbaum, L. R., Ramirez, R. G., & Absalon, K. B. (1975). What is the mechanism of carbon monoxide toxicity? Aviation, Space, and Environmental Medicine, 46(10), 1289-91.
Goldbaum LR, Ramirez RG, Absalon KB. What Is the Mechanism of Carbon Monoxide Toxicity. Aviat Space Environ Med. 1975;46(10):1289-91. PubMed PMID: 1180795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What is the mechanism of carbon monoxide toxicity? AU - Goldbaum,L R, AU - Ramirez,R G, AU - Absalon,K B, PY - 1975/10/1/pubmed PY - 1975/10/1/medline PY - 1975/10/1/entrez SP - 1289 EP - 91 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 46 IS - 10 N2 - The probable toxic action is CO is on the cellular respiration, in which CO competes with O2 for cytochrome a3. Our studies indicate that a relatively high concentration of COHb (50%) does not interfere with the O2-carrying capacity of the blood. The dissolved CO in plasma, which is necessary for CO to enter the tissue, probably occurs when the exchange takes place between alveolar air and the blood in the lungs. This would explain why the central nervous system could be impaired when COHb levels are below 10% and death could occur at 35%. SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/1180795/What_is_the_mechanism_of_carbon_monoxide_toxicity DB - PRIME DP - Unbound Medicine ER -