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Antimicrobial activity of everninomicin against clinical isolates of Enterococcus spp., Staphylococcus spp., and Streptococcus spp. tested by Etest.
J Infect Chemother. 2001 Dec; 7(4):263-6.JI

Abstract

The in-vitro antimicrobial activity of everninomicin, a novel oligosaccharide antibiotic, was tested against clinical isolates of 11 methicillin-susceptible Staphylococcus aureus (MSSA) strains, 11 methicillin-resistant S. aureus (MRSA) strains, 22 Staphylococcus epidermidis strains, 23 Enterococcus faecalis strains, 23 Enterococcus faecium strains, 23 Enterococcus avium strains, 27 Streptococcus pneumoniae strains, 22 Streptococcus pyogenes strains, and 20 Streptococcus agalactiae strains. The minimum inhibitory concentrations (MICs) of everninomicin were determined by Etest and compared with those of vancomycin, teicoplanin, and minocycline. The Etest showed that everninomicin exhibited excellent activity (MIC, <0.016 to 1.5 microg/ml) against the gram-positive cocci tested. The antimicrobial activity of everninomicin against S. aureus and S. epidermidis was stronger than that of vancomycin, teicoplanin, and minocycline, in particular against MRSA, with an MIC50 of 0.38 microg/ml and an MIC90 of 0.5 microg/ml. Against strains of enterococci and streptococci, everninomicin was more active than vancomycin, but as active as teicoplanin.

Authors+Show Affiliations

Department of Microbiology, St. Marianna University School of Medicine, Sugao, Miyamae, Kawasaki, Kanagawa 216-8511, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11810596

Citation

Terakubo, S, et al. "Antimicrobial Activity of Everninomicin Against Clinical Isolates of Enterococcus Spp., Staphylococcus Spp., and Streptococcus Spp. Tested By Etest." Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, vol. 7, no. 4, 2001, pp. 263-6.
Terakubo S, Takemura H, Yamamoto H, et al. Antimicrobial activity of everninomicin against clinical isolates of Enterococcus spp., Staphylococcus spp., and Streptococcus spp. tested by Etest. J Infect Chemother. 2001;7(4):263-6.
Terakubo, S., Takemura, H., Yamamoto, H., Ikejima, H., Kunishima, H., Kanemitsu, K., Kaku, M., & Shimada, J. (2001). Antimicrobial activity of everninomicin against clinical isolates of Enterococcus spp., Staphylococcus spp., and Streptococcus spp. tested by Etest. Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, 7(4), 263-6.
Terakubo S, et al. Antimicrobial Activity of Everninomicin Against Clinical Isolates of Enterococcus Spp., Staphylococcus Spp., and Streptococcus Spp. Tested By Etest. J Infect Chemother. 2001;7(4):263-6. PubMed PMID: 11810596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial activity of everninomicin against clinical isolates of Enterococcus spp., Staphylococcus spp., and Streptococcus spp. tested by Etest. AU - Terakubo,S, AU - Takemura,H, AU - Yamamoto,H, AU - Ikejima,H, AU - Kunishima,H, AU - Kanemitsu,K, AU - Kaku,M, AU - Shimada,J, PY - 2001/02/01/received PY - 2001/05/16/accepted PY - 2002/1/26/pubmed PY - 2002/2/22/medline PY - 2002/1/26/entrez SP - 263 EP - 6 JF - Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy JO - J Infect Chemother VL - 7 IS - 4 N2 - The in-vitro antimicrobial activity of everninomicin, a novel oligosaccharide antibiotic, was tested against clinical isolates of 11 methicillin-susceptible Staphylococcus aureus (MSSA) strains, 11 methicillin-resistant S. aureus (MRSA) strains, 22 Staphylococcus epidermidis strains, 23 Enterococcus faecalis strains, 23 Enterococcus faecium strains, 23 Enterococcus avium strains, 27 Streptococcus pneumoniae strains, 22 Streptococcus pyogenes strains, and 20 Streptococcus agalactiae strains. The minimum inhibitory concentrations (MICs) of everninomicin were determined by Etest and compared with those of vancomycin, teicoplanin, and minocycline. The Etest showed that everninomicin exhibited excellent activity (MIC, <0.016 to 1.5 microg/ml) against the gram-positive cocci tested. The antimicrobial activity of everninomicin against S. aureus and S. epidermidis was stronger than that of vancomycin, teicoplanin, and minocycline, in particular against MRSA, with an MIC50 of 0.38 microg/ml and an MIC90 of 0.5 microg/ml. Against strains of enterococci and streptococci, everninomicin was more active than vancomycin, but as active as teicoplanin. SN - 1341-321X UR - https://www.unboundmedicine.com/medline/citation/11810596/Antimicrobial_activity_of_everninomicin_against_clinical_isolates_of_Enterococcus_spp__Staphylococcus_spp__and_Streptococcus_spp__tested_by_Etest_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1341-321X(01)71257-3 DB - PRIME DP - Unbound Medicine ER -