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[bcl-2 and p53 protein expressions in the malignant transformation of ovarian endometriosis].
Zhonghua Zhong Liu Za Zhi. 2001 Sep; 23(5):403-5.ZZ

Abstract

OBJECTIVE

To study the impact of bcl-2 and p53 protein expressions on the malignant transformation of ovarian endometriosis.

METHODS

Immunohistochemical technique was used to detect the bcl-2 and p53 protein expressions in: endometriosis (Group I, 22 patients), atypical hyperplasia of ectopic ovarian endometrial glands (Group II, 14 patients) and endometriosis with malignant change (Group III, 22 patients).

RESULTS

The positive bcl-2 protein expression rate of Group III was apparently higher than that of Group I (P < 0.05); The positive bcl-2 protein expression rate of Group II was clearly higher than that of Group I(P < 0.01). The positive p53 protein expression rate of Group III was higher than that of Group II (P < 0.01) and Group I (P < 0.01); In Group III, the positive p53 protein expression rate was higher in the malignant transformation area than in the endometriosis area (P < 0.05); In Group III, the positive bcl-2 protein expression rate in the endometriosis area was higher than that of Group I (P < 0.05); In Group II, the positive bcl-2 protein expression rate in the endometriosis area was higher than that of Group I (P < 0.01); However, the bcl-2 and p53 protein expressions were not related to the menopause, stage of disease or the survival (P > 0.05), nor were they related to the malignant transformation area in Group III (P > 0.05).

CONCLUSION

It is possible that the overexpressions of bcl-2 protein or p53 protein play an important role in the malignant transformation of ovarian endometriosis. The bcl-2 protein (+) or p53 protein (+) endometriosis may signify a precancerous lesion.

Authors+Show Affiliations

Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11810773

Citation

Qian, J, and Y Shi. "[bcl-2 and P53 Protein Expressions in the Malignant Transformation of Ovarian Endometriosis]." Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], vol. 23, no. 5, 2001, pp. 403-5.
Qian J, Shi Y. [bcl-2 and p53 protein expressions in the malignant transformation of ovarian endometriosis]. Zhonghua Zhong Liu Za Zhi. 2001;23(5):403-5.
Qian, J., & Shi, Y. (2001). [bcl-2 and p53 protein expressions in the malignant transformation of ovarian endometriosis]. Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], 23(5), 403-5.
Qian J, Shi Y. [bcl-2 and P53 Protein Expressions in the Malignant Transformation of Ovarian Endometriosis]. Zhonghua Zhong Liu Za Zhi. 2001;23(5):403-5. PubMed PMID: 11810773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [bcl-2 and p53 protein expressions in the malignant transformation of ovarian endometriosis]. AU - Qian,J, AU - Shi,Y, PY - 2002/1/29/pubmed PY - 2002/3/13/medline PY - 2002/1/29/entrez SP - 403 EP - 5 JF - Zhonghua zhong liu za zhi [Chinese journal of oncology] JO - Zhonghua Zhong Liu Za Zhi VL - 23 IS - 5 N2 - OBJECTIVE: To study the impact of bcl-2 and p53 protein expressions on the malignant transformation of ovarian endometriosis. METHODS: Immunohistochemical technique was used to detect the bcl-2 and p53 protein expressions in: endometriosis (Group I, 22 patients), atypical hyperplasia of ectopic ovarian endometrial glands (Group II, 14 patients) and endometriosis with malignant change (Group III, 22 patients). RESULTS: The positive bcl-2 protein expression rate of Group III was apparently higher than that of Group I (P < 0.05); The positive bcl-2 protein expression rate of Group II was clearly higher than that of Group I(P < 0.01). The positive p53 protein expression rate of Group III was higher than that of Group II (P < 0.01) and Group I (P < 0.01); In Group III, the positive p53 protein expression rate was higher in the malignant transformation area than in the endometriosis area (P < 0.05); In Group III, the positive bcl-2 protein expression rate in the endometriosis area was higher than that of Group I (P < 0.05); In Group II, the positive bcl-2 protein expression rate in the endometriosis area was higher than that of Group I (P < 0.01); However, the bcl-2 and p53 protein expressions were not related to the menopause, stage of disease or the survival (P > 0.05), nor were they related to the malignant transformation area in Group III (P > 0.05). CONCLUSION: It is possible that the overexpressions of bcl-2 protein or p53 protein play an important role in the malignant transformation of ovarian endometriosis. The bcl-2 protein (+) or p53 protein (+) endometriosis may signify a precancerous lesion. SN - 0253-3766 UR - https://www.unboundmedicine.com/medline/citation/11810773/[bcl_2_and_p53_protein_expressions_in_the_malignant_transformation_of_ovarian_endometriosis]_ L2 - http://www.diseaseinfosearch.org/result/2537 DB - PRIME DP - Unbound Medicine ER -